scholarly journals The Impact of Ultraviolet Radiation on the Aetiology and Development of Uveal Melanoma

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1700
Author(s):  
Melissa Chalada ◽  
Charmaine A. Ramlogan-Steel ◽  
Bijay P. Dhungel ◽  
Christopher J. Layton ◽  
Jason C. Steel

Uveal melanoma (UM) is currently classified by the World Health Organisation as a melanoma caused by risk factors other than cumulative solar damage. However, factors relating to ultraviolet radiation (UVR) susceptibility such as light-coloured skin and eyes, propensity to burn, and proximity to the equator, frequently correlate with higher risk of UM. These risk factors echo those of the far more common cutaneous melanoma (CM), which is widely accepted to be caused by excessive UVR exposure, suggesting a role of UVR in the development and progression of a proportion of UM. Indeed, this could mean that countries, such as Australia, with high UVR exposure and the highest incidences of CM would represent a similarly high incidence of UM if UVR exposure is truly involved. Most cases of UM lack the typical genetic mutations that are related to UVR damage, although recent evidence in a small minority of cases has shown otherwise. This review therefore reassesses statistical, environmental, anatomical, and physiological evidence for and against the role of UVR in the aetiology of UM.

Author(s):  
Arati Raut ◽  
Ruchira Ankar ◽  
Sheetal Sakharkar

COVID-19 was proven to be a pandemic in early 2020 by the World Health Organisation (WHO). At present, 213 countries have been affected by the COVID-19 pandemic. In the history of global pandemics, COVID-19 has had a major impact on society as it has killed humans, spread human suffering and uprooted the lives of the people. Across the globe, there are 18,705,096 confirmed cases, 11,922,692 recovered cases, 704,385 deaths, and 6,078,019 active cases as of, 5 August 2020. It has affected the world’s economic, social and political status. Poor people belonging to the lower strata of society face more difficulties during pandemics. They are unable to secure their daily bread as well as other basic needs. The impact of COVID-19 on the poor and the role of society have been addressed.


Author(s):  
Oksana Rybachok

According to the World Health Organisation, deafness is one of the most widely spread sensory disorders in the world affecting about 360 million people worldwide. The causes of deafness can be very diverse, from genetic diseases, the impact of injury-risk factor and infectious agents to the administration of ototoxic drugs. Moreover, otolaryngologists believe that about half of deafness and hearing loss cases could have been prevented. Though otolaryngology was separated as an independent medical science in the mid-18th century, the decision to celebrate the Otolaryngologist Day on September 29 as a professional holiday for medical practitioners in this speciality was made not so long ago. This date at the end of September was chosen on purpose: the influx of patients to medical practitioners in this speciality is observed closer to the mid-autumn, after the first cold snap.


2017 ◽  
Vol 45 (9) ◽  
Author(s):  
Kelly-Ann Eastwood ◽  
Ciara Daly ◽  
Alyson Hunter ◽  
David McCance ◽  
Ian Young ◽  
...  

AbstractObjective:To examine the impact of maternal obesity on completion of fetal anomaly screening.Methods:A retrospective analysis of 500 anomaly scans (19+0–21+6 weeks) was included. Women were categorised according to the World Health Organisation (WHO) body mass index (BMI) classification: normal weight (18.50–24.99 kg/mResults:Image quality deteriorated as BMI increased and was significantly different across the BMI categories (P<0.001). Performance was poorest in imaging of the fetal chest and was significantly different across BMI categories (P<0.001). In obese class III, 33% of four-chamber cardiac views and 38% of outflow tract views were not obtained. In total, 119 women (23.6%) had an incomplete scan. In obese class III, 44.1% of scans were incomplete compared with 10.2% in the normal BMI category (P<0.001). Of 117 women attending for repeat scans, 78.6% were complete, 11.1% were incomplete, 6.8% were advised to re-attend and 3.4% were referred to Fetal Medicine.Conclusion:Maternal obesity has a significant impact on completion of fetal anomaly screening.


2010 ◽  
Vol 25 (5) ◽  
pp. 257-260 ◽  
Author(s):  
J R H Scurr ◽  
N Ahmad ◽  
D Thavarajan ◽  
R K Fisher

Introduction This study has examined the impact of the World Health Organization's Research into Global Hazards of Travel (WRIGHT) Project's phase 1 report on the information given by airlines to their passengers regarding traveller's thrombosis. Methods Official websites of all airlines flying from Heathrow (UK) and John F Kennedy (USA) were located through links on the websites of these two busy international airports. In June 2007, each site was scrutinized by three independent researchers to identify if traveller's thrombosis and its risk factors were discussed and what methods of prevention were advised. This exercise was repeated a year after the publication of the WRIGHT report. Results One hundred and nineteen international airlines were listed in 2007 (12 were excluded from analysis). A quarter (27/107) of airlines warned of the risk of traveller's thrombosis. A year later, five airlines were no longer operational and there had been no increase in the discussion of traveller's thrombosis (23/102). Additional risk factors discussed in June 2007 versus September 2008: previous venous thromboembolism (16%, 15%); thrombophilia (14%, 15%); family history (11%, 9%); malignancy (12%, 14%); recent surgery (19%, 16%); pregnancy (17%, 16%) and obesity (11%, 12%). Prophylaxis advice given in June 2007 versus September 2008: in-flight exercise (34%, 42%); Hydration (30%, 34%); medical consultation prior to flying (20%, 18%); graduated compression stockings (13%, 12%); aspirin (<1%, <1%) and heparin (5%, 7%). Conclusions The majority of world airlines continue to fail to warn of the risk of traveller's thrombosis or offer appropriate advice. Alerting passengers at risk gives them an opportunity to seek medical advice before flying.


2021 ◽  
Vol 39 ◽  
Author(s):  
Balcha Masresha ◽  
Richard Luce ◽  
Reggis Katsande ◽  
Annick Dosseh ◽  
Patricia Tanifum ◽  
...  

2021 ◽  
Vol 2 (1) ◽  
pp. 25-30
Author(s):  
Pham Hoang

The purpose of this article is to describe the capacity and role of WHO in dealing with the spread of COVID-19 and to discuss in-depth articles at the stages of policy implementation that specifically discuss the WHO protocol that is applied in dealing with the spread of Covid-19. The implementation of the policy to handle the spread of COVID-19 considers various aspects not only health but also the economic and social impacts resulting from government decision making. In addition, response measures are implemented through the Acceleration of COVID-19 Handling task which is part of the formation of structures, structure is one of the aspects that are considered in Edward III's implementation theory besides communication, resources and disposition because the presence of a structure helps implement policies has a significant effect. on policy implementation. The support of all elements of the government, the private sector in compliance with government and WHO instructions, especially regarding social distancing and physical distancing, will have a big impact in preventing the spread of COVID-19.


2020 ◽  
Author(s):  
Diane Ashiru-Oredope ◽  
Amy Chan ◽  
Omotayo Olaoye ◽  
Victoria Rutter ◽  
Zaheer-Ud-Din Babar ◽  
...  

Abstract BackgroundThe declaration of COVID-19 a pandemic by the World Health Organisation on the 11March 2020 marked the beginning of a global health crisis of an unprecedented natureand scale. The approach taken by countries across the world varied widely, however,the delivery of frontline healthcare was consistently recognised as being central to thepandemic response. This study aimed to identify and explore the issues currentlyfacing pharmacy teams across Commonwealth countries during the COVID-19pandemic. The study also evaluates pharmacy professionals’ understanding of keyknowledge areas from the COVID-19 webinar hosted by the CommonwealthPharmacists’ Association ( CPA) on 5 th June 2020.MethodA quantitative survey-based approach was adopted, using a 32-item questionnairedeveloped from the literature on pharmacy and pandemic response. The survey washosted on Survey Monkey and pilot tested. The final survey was disseminated by CPAmember organisations. A 6-item online questionnaire was sent via email to allattendees of CPA's COVID-19 webinar. Descriptive statistics on frequency distributionsand percentages were used to analyse the responses. Data were analysed usingMicrosoft® Excel (2010).ResultsThere were 545 responses from pharmacy professionals across 31/54 commonwealthcountries in Africa, Asia, the Americas, Europe and the Pacific. Majority of therespondents reported being at least somewhat worried (90%) and more than 65% werevery worried or extremely about the impact of COVID-19 on them personally andprofessionally. Nearly two-thirds of respondents stated finding it somewhat difficult orvery difficult to work effectively during the pandemic. Challenges mostly faced bypharmacy professionals working remotely included; general anxiety about the impact ofCOVID-19 on their lives (12%), and difficulties in communicating with their co-workers(12%). Most pharmacy professionals had not previously been actively involved in aglobal health emergency (82%) nor obtained training on global/public healthemergency preparedness (62%). Between 45% to 97% of the COVID-19 webinarattendees provided the correct answers to post-webinar questions, suggesting someimprovement in knowledge.ConclusionOur study confirms pharmacy professional’s concerns about practice during apandemic and provides preliminary data on the challenges and learning needs of theprofession. The CPA has since acted on these findings, providing on-goingopportunities to develop and refine resources for the profession as the pandemicevolves. Pharmacy professionals have also demonstrated improved knowledge on themanagement of COVID-19 and resources available for professionals.


2020 ◽  
Vol 11 (SPL1) ◽  
pp. 165-170
Author(s):  
Rajni Kamlakar Gurmule

Today the whole world is suffering from the most dreadful disease that is Covid 19. The Causative factor for COVID 19 is SARS-COV2. It was ϑirst noticed in Wuhan city of China. World Health Organisation declared the fatality of this disease as a pandemic. This disease has become a problem of great concern globally. This virus targets the respiratory system of human beings. There is a high incidence of person to person transmission of this disease through contact. However, there is also a signiϑicant role in innate immunity in pathogenesis and management of this disease. The whole world is seeking for ϑlawless control of this viral disease. Ayurveda is a holistic science. Its aim is not only on the cure of diseases but also on its prevention. It emphasises mainly on healthy life of an individual. There is a wide range of principles described in Ayurveda which are used to combat disease from its root. Rasayana Chikista is a useful principle of Ayurveda, beneϑicial for management and prevention of many diseases. It is always said that “prevention is better than cure”. Chyavanprash is one of the well known Rasayana. Contents of Chyavanprash shows a wide range of actions on respiratory diseases as well as on boosting immunity. These properties of it provoke us to review the role of Chyavanprash in the prevention of Covid 19, thereby increasing one’s immune response. This Chyavanaprash can be a boon in the prevention of Covid 19 by improving immunity against it.


Viruses ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 138 ◽  
Author(s):  
Hermann Meyer ◽  
Rosina Ehmann ◽  
Geoffrey L. Smith

Widespread vaccination programmes led to the global eradication of smallpox, which was certified by the World Health Organisation (WHO), and, since 1978, there has been no case of smallpox anywhere in the world. However, the viable variola virus (VARV), the causative agent of smallpox, is still kept in two maximum security laboratories in Russia and the USA. Despite the eradication of the disease smallpox, clandestine stocks of VARV may exist. In a rapidly changing world, the impact of an intentional VARV release in the human population would nowadays result in a public health emergency of global concern: vaccination programmes were abolished, the percentage of immunosuppressed individuals in the human population is higher, and an increased intercontinental air travel allows for the rapid viral spread of diseases around the world. The WHO has authorised the temporary retention of VARV to enable essential research for public health benefit to take place. This work aims to develop diagnostic tests, antiviral drugs, and safer vaccines. Advances in synthetic biology have made it possible to produce infectious poxvirus particles from chemicals in vitro so that it is now possible to reconstruct VARV. The status of smallpox in the post-eradication era is reviewed.


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