Ki-67 (clone MIB-1) proliferation index in recurrent glial neoplasms: no prognostic significance

1998 ◽  
Vol 50 (6) ◽  
pp. 579-585 ◽  
Author(s):  
N.Scott Litofsky ◽  
T.-Christian H. Mix ◽  
Stephen P. Baker ◽  
Lawrence D. Recht ◽  
Thomas W. Smith
Keyword(s):  
Prognostic Significance ◽  
Proliferation Index ◽  
Ki 67 ◽  
Mib 1

Predictors of invasive breast cancer or DCIS recurrence in estrogen receptor positive (ER+) and estrogen receptor negative (ER-) ductal carcinoma in situ (DCIS) patients with and without associated invasive carcinoma (IC)

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e11523-e11523 ◽  
Author(s):  
J. Picarsic ◽  
A. Brufsky ◽  
A. Onisko ◽  
M. Chivukula
Keyword(s):  
Estrogen Receptor ◽  
Biological Markers ◽  
Hormone Receptors ◽  
Invasive Carcinoma ◽  
Ductal Carcinoma ◽  
Response To Therapy ◽  
Proliferation Index ◽  
Low Grade ◽  
Ki 67 ◽  
Mib 1

e11523 Background: DCIS is a heterogeneous pre-invasive carcinoma with a spectrum of clinical behavior. Patients with ER+ IC have better outcomes compared to ER- patients. FOXA1 and GATA 3 family of transcription factors have been shown to be associated with hormone receptors (ER and PR) and other variables of good prognosis with better overall and relapse-free survival rate. The specific aim of this study is to analyze the expression of these novel biological markers: FOXA1, GATA-3, with recognized markers: MIB-1(Ki-67) and HER2 /neu in DCIS patients with/without associated IC. Methods: Sixty-nine (69) cases of DCIS [(fifty two (52) cases in ER+; seventeen (17) in ER-] were retrieved from our Pathology database. The expressions of the biological markers are analyzed by using a panel of immunohistochemical stains. FOXA1, GATA 3, ER, PR are nuclear stains, a cumulative “H score” is derived based on proportionality (PS) and intensity scores (IS). A proliferation index (PI) is calculated for MIB-1 (Ki67) nuclear stain (low <10%, moderate 11–25%, high 26–50%, very high>50%). Her2/neu is scored as per guidelines for HercepTest (0, or 1+ =negative, 2+ =weakly positive, 3+ =strongly positive). Results: DCIS is categorized into low grade (LG) (nuclear grade 1 and 2), high grade (HG) (grade 3). In the HGDCIS (n=48), four (4) cases had IC after a mean of 7.75 years; three cases of recurrent DCIS after a mean 6 years. No recurrent IC or DCIS is seen in the LGDCIS (n=21) group. The results are shown in the Table . Conclusions: (1) Decreased expression of GATA 3 is observed in HGDCIS ER- group may be a contributor to higher recurrence observed in this group (14%) versus (0%) in ER+ group. (2) A strong expression of FOXA, GATA3, low Ki-67 index, absent Her 2 expression are characteristically seen in our ER+ DCIS group, as previously described in IC. 3. Comparing the response to therapy and outcome in the ER+ and ER- groups is on going. [Table: see text] No significant financial relationships to disclose.

Primary Cutaneous Small/Medium CD4+ T-Cell Lymphomas: A Heterogeneous Group of Tumors With Different Clinicopathologic Features and Outcome

2008 ◽  
Vol 26 (20) ◽  
pp. 3364-3371 ◽  
Author(s):  
Adriana Garcia-Herrera ◽  
Luis Colomo ◽  
Mireia Camós ◽  
Joaquín Carreras ◽  
Olga Balague ◽  
...  
Keyword(s):  
T Cell ◽  
Prognostic Significance ◽  
Heterogeneous Group ◽  
Automated Image Analysis ◽  
Proliferation Index ◽  
Image Analysis System ◽  
Ki 67 ◽  
Cutaneous Lymphomas ◽  
Analysis System

Purpose To define the clinical and pathologic characteristics of primary cutaneous small/medium CD4+ T-cell lymphoma (PCSM-TCL) and identify parameters of prognostic significance. Patients and Methods We have investigated 24 patients with primary cutaneous lymphomas composed of small/medium mature T-cells with a βF1, CD3, CD4+ and/or noncytotoxic, CD8– and CD30– phenotype. The proliferation index and CD8+ infiltrating cells were quantified with an automated image analysis system. Results Sixteen patients presenting with solitary or localized plaques or small nodules (< 3 cm) had an indolent course. Only three patients experienced repeated cutaneous relapses, and none of them died as a result of the disease after 1 to 168 months (median, 17 months) of follow-up. The tumors had a low proliferation (median Ki-67, 9% ± 5%) and an intense infiltrate of reactive CD8+ (median, 20% ± 11.7%). Five patients presenting with rapidly evolving large tumors or nodules (≥ 5 cm) had an aggressive disease and died with extracutaneous dissemination 18 to 36 months after diagnosis (median, 23 months). These tumors had a significantly higher proliferation (median Ki-67, 22% ± 11.3%; P < .05) and lower number of infiltrating CD8+ (median, 1% ± 3%; P < .05) than the previous group. A third group of three patients had a peculiar clinical presentation with multifocal relapsing lesions without extracutaneous dissemination after a long period of follow-up ranging from 41 to 92 months. Histologically, these cases had an intense infiltrate of eosinophils. Conclusion PCSM-TCL is a heterogeneous group of tumors with differentiated clinical and pathological characteristics with impact in the outcome of the patients.

Classification Model to Estimate MIB-1 (Ki 67) Proliferation Index in NSCLC Patients Evaluated With 18F-FDG-PET/CT

2020 ◽  
Vol 40 (6) ◽  
pp. 3355-3360
Author(s):  
BARBARA PALUMBO ◽  
ROSANNA CAPOZZI ◽  
FRANCESCO BIANCONI ◽  
MARIO LUCA FRAVOLINI ◽  
SILVIA CASCIANELLI ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Classification Model ◽  
Proliferation Index ◽  
Ki 67 ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Nsclc Patients ◽  
Mib 1
Sign in / Sign up

Export Citation Format

Share Document