Cellular immuno-competence of infected root canal contents in pathogenesis of periapical lesions

1997 ◽  
Vol 23 (4) ◽  
pp. 213-216 ◽  
Author(s):  
Junji Ninomiya ◽  
Keiji Nakanishi ◽  
Toshinobu Takemoto ◽  
Tomie Higashi ◽  
Tetsuji Ogawa ◽  
...  
2020 ◽  
Vol 75 (10) ◽  
pp. 553-563
Author(s):  
Maheshan Pillay ◽  
Martin Vorster ◽  
Peet J Van der Vyver

Instrument fracture is a serious complication during endodontic treatment of teeth, having an adverse effect on the outcome of the nickel titanium (NiTi) treatment, especially if the fracture prevents apical access to the infected root canal. Despite the advent of NiTi files, the risk of fracture during the endodontic preparation of root canals, especially in severely curved canals, remains a serious concern. The fracture of NiTi files during preparation may result in a compromised prognosis for the tooth. In the presence of periapical lesions, instrument fracture may reduce the chances of successful healing.


2010 ◽  
Vol 9 (1) ◽  
pp. 63
Author(s):  
Indrya Kirana Mattulada

Bacteria and their products play a fundamental role in the initiation, propagation andpersistence of pulpal and periradicular diseases. Consequently one of the major goalsof endodontic treament is to eliminate all bacteria from the root canal space.Elimination of microorganism from infected root canal is a complicated task.Numerous measures have been described to reduce the numbers of root canalmicroorganism, including the use of various instrumentation techniques, irrigationregimens, and intracanal medication. In endodontic treatment, there are severalmedicament used traditionally. They are phenolic, aldehyde, halogen, calciumhydroxide, and antibiotic. The aim of this paper is to discuss about indication,contraindication and effect of each medicament.


2018 ◽  
Vol 6 (2) ◽  
pp. 389-396 ◽  
Author(s):  
Nexhmije Ajeti ◽  
Teuta Pustina-Krasniqi ◽  
Sonja Apostolska ◽  
Edit Xhajanka

OBJECTIVES: During the treatment of chronic apical periodontitis and pulp necrosis the main role is to irrigate the root canal.AIM: The aim of this in vivo study was to irrigate with 0.9% NaCl (Natrium Chloride), 2.5 % NaOCl (Sodium Hypochlorite Solution, Sigma Aldrich - Germany) and 2% CHX (Chlorhexidine Digluconate Solution, Sigma Aldrich - Spain) combined with Gaseous Ozone (Prozone WH, Austria).MATERIAL AND METHODS: This study was realised in the University Dentistry Clinical Centre of Kosovo (UDCCK), respectively in the Department of Endodontic and Dental Pathology, Dental Branch, Faculty of Medicine, Prishtina, Kosovo. The 40 subjects involved in this study belonged to both genders, in age between 15 -65 years. The sample selection was randomised. The retroalveolar radiography for each patient was taken in the suspected tooth. As a therapeutic plan the authors decided to disinfect the root canal with the irrigants, as follows: 2.5 % NaOCl, 2 % CHX and gaseous ozone.RESULTS: The statistical analyses were based on Kruskal - Vallis test, X - test, DF = 3, r < 0.01. In the isolated average number of the aerobe and anaerobe bacteria colonies, when gaseous ozone was used, there was the significant statistical difference.CONCLUSIONS: When gaseous ozone was combined with irrigants 0.9%, 2.5 % NaOCl and 2% CHX, it was concluded that the number of colonies of aerobic and anaerobic bacteria was reduced.


2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Sheela B. Abraham ◽  
Farah al Marzooq ◽  
Wan Harun Himratul-Aznita ◽  
Hany Mohamed Aly Ahmed ◽  
Lakshman Perera Samaranayake

Abstract Background There is limited data on the prevalence of Candida species in infected root canal systems of human teeth. We attempted to investigate the prevalence, genotype, virulence and the antifungal susceptibility of Candida albicans isolated from infected root canals of patients with primary and post-treatment infections in a UAE population. Methods Microbiological samples from 71 subjects with infected root canals were aseptically collected, and cultured on Sabouraud dextrose agar, and C. albicans was identified using multiplex polymerase chain reaction, and the isolates were further subtyped using ABC genotyping system. Their relative virulence was compared using further four archival samples of endodontic origin from another geographical region, and four more salivary isolates, as controls. The virulence attributes compared were biofilm formation, and production of phospholipase and haemolysin, and the susceptibility to nystatin, amphotericin B, ketoconazole, and fluoconazole was also tested. Results 4 out of 71 samples (5.6%) yielded Candida species. On analysis of variance among the groups, the intracanal isolates, mainly Genotype A, possessed a high degree of phospholipase and haemolysin activity (p < 0.05). The UAE and Finland isolates were stronger biofilm formers and had superior phospholipase production capacity compared with the salivary isolates. All isolates were sensitive to the antifungal chemicals used. The salivary isolates were more sensitive to fluoconazole compared to other groups (p < 0.05). Conclusion The prevalence of C. albicans in infected root canals of patients attending a dental hospital in UAE is low. The strains isolated were good biofilm formers, possessed strong phospholipase and haemolysin activity and were mostly of the genotype A. The fact that the root canal isolates possessed significant hydrolase activity, imply that they are equipped with virulence attributes necessary for survival within a harsh intracanal ecosystem.


2015 ◽  
Vol 56 (3) ◽  
pp. 169-175 ◽  
Author(s):  
Masataka Suehara ◽  
Yosuke Sano ◽  
Ryo Sako ◽  
Natsuko Aida ◽  
Rie Fujii ◽  
...  

2021 ◽  
Author(s):  
Jelena Marinković ◽  
Biljana Nikolić ◽  
Tatjana Marković ◽  
Milena Radunović ◽  
Jugoslav Ilić ◽  
...  

Aim: The objective was to formulate and characterize the nanoemulsion based on Cymbopogon citratus oil, intended for use in teeth infected root canal therapy. The investigation of the antioxidant and antibiofilm potential toward Enterococcus faecalis was aimed as well. Materials & methods: Characterization of oil (by GC/MS analysis) and nanoemulsion (by dynamic light scattering instrument), and determination of antibacterial (by microdilution assay), antibiofilm (by crystal violet assay) and antioxidant properties (by 2,2-diphenyl-1-picryl-hydrazyl-hydrate and thiobarbituric acid assay methods) were provided. Antibiofilm efficacy of irrigation procedure including nanoemulsion was screened on extracted teeth (by CFU counting assay). Results: Notable antibacterial and antibiofilm activity, both against forming and preformed biofilms of oil, was observed. Irrigation involved nanoemulsion showed remarkable antibiofilm potential. Both substances induced some antioxidant activity. Conclusion: Results encourage further research with the aim of application of the nanoemulsion in dental practice.


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