Epidermolysis bullosa letalis in the larynx causing acute respiratory failure: a case presentation and review of the literature

1984 ◽  
Vol 7 (3) ◽  
pp. 281-288 ◽  
Author(s):  
Lawrence Paul Glossop ◽  
Leslie Michaels ◽  
Christian Martin Bailey
Keyword(s):  
Respiratory Failure ◽  
Acute Respiratory Failure ◽  
Epidermolysis Bullosa ◽  
Review Of The Literature ◽  
Case Presentation

Is Therapeutic Hypothermia for Acute Respiratory Distress Syndrome the Future?

2017 ◽  
Vol 32 (7) ◽  
pp. 460-464 ◽  
Author(s):  
Adam J. Hayek ◽  
Heath D. White ◽  
Shekhar Ghamande ◽  
Christopher Spradley ◽  
Alejandro C. Arroliga
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Failure ◽  
Acute Respiratory Failure ◽  
Respiratory Distress Syndrome ◽  
Therapeutic Hypothermia ◽  
Distress Syndrome ◽  
Current Evidence ◽  
Evidence Based ◽  
Review Of The Literature ◽  
Evidence Based Therapy

Introduction: Severe acute respiratory distress syndrome (ARDS) has a high mortality, and there is limited knowledge about management of severe ARDS refractory to standard therapy. Early evidence suggests that therapeutic hypothermia (TH) could be a viable treatment for acute respiratory failure. We present 2 cases where TH was successfully used to manage refractory ARDS on extracorporeal membrane oxygenation (ECMO) and a review of the literature around TH and acute respiratory failure. Results: We present 2 cases of ARDS secondary to H1N1 influenza and human metapneumovirus. Both patients were treated with the current evidence-based therapy for ARDS. Venovenous ECMO was used in both patients for refractory hypoxemia. Therapeutic hypothermia was applied for 24 hours with improved oxygenation. We did a review of the literature summarizing 38 patients in 10 publications where TH was successfully utilized in the treatment of acute respiratory failure. Conclusion: Therapeutic hypothermia may be a viable salvage therapy for ARDS refractory to the current evidence-based therapy but needs further evaluation.

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