OC-0352: Planning target volume margins needed for radiotherapy of carcinoma of the anal canal and inguinal lymph nodes

Because of their rarity, there are no clear guidelines for the treatment of anal carcinomas; such tumors are normally subjected to the same modalities as recommended for rectal cancer. We report a patient with anal canal mucinous adenocarcinoma, with metastases in the pararectal and right inguinal lymph nodes, who was treated with abdominoperineal resection followed by mFOLFOX6 chemotherapy for 6 months (12 cycles). The patient has remained recurrence-free thus far, approximately 2 years since the surgery. As the optimal treatments for anal carcinomas have not been fully elucidated, we present this case to highlight a possible course of action for such patients that appears to be effective and promising.

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EP-1777: MRT investigation of prostate and lymph nodes movements: implications on planning target volume?

Radiotherapy and Oncology ◽

10.1016/s0167-8140(16)33028-6 ◽

2016 ◽

Vol 119 ◽

pp. S833

Author(s):

U. Björeland

Keyword(s):

Lymph Nodes ◽

Planning Target Volume ◽

Target Volume

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REPEATABILITY OF A PLANNING TARGET VOLUME EXPANSION PROTOCOL FOR RADIATION THERAPY OF REGIONAL LYMPH NODES IN CANINE AND FELINE PATIENTS WITH HEAD TUMORS

Veterinary Radiology & Ultrasound ◽

10.1111/j.1740-8261.2012.01972.x ◽

2012 ◽

Vol 53 (6) ◽

pp. 667-672 ◽

Cited By ~ 11

Author(s):

Hiroto Yoshikawa ◽

Joseph F. Harmon ◽

James T. Custis ◽

Susan M. LaRue

Keyword(s):

Radiation Therapy ◽

Lymph Nodes ◽

Planning Target Volume ◽

Volume Expansion ◽

Target Volume ◽

Regional Lymph Nodes ◽

Head Tumors ◽

Expansion Protocol

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Risk Factors of Synchronous Inguinal Lymph Nodes Metastasis for Lower Rectal Cancer Involving the Anal Canal

PLoS ONE ◽

10.1371/journal.pone.0111770 ◽

2014 ◽

Vol 9 (11) ◽

pp. e111770 ◽

Cited By ~ 3

Author(s):

Renjie Wang ◽

Peng Wu ◽

Debing Shi ◽

Hongtu Zheng ◽

Liyong Huang ◽

...

Keyword(s):

Risk Factors ◽

Rectal Cancer ◽

Lymph Nodes ◽

Anal Canal ◽

Lower Rectal Cancer ◽

Inguinal Lymph Nodes ◽

Lymph Nodes Metastasis

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Patterns of pathologic lymph nodes in anal cancer: a PET-CT-based analysis with implications for radiotherapy treatment volumes

BMC Cancer ◽

10.1186/s12885-021-08187-8 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Anna Frennered ◽

Jonas Scherman ◽

Pamela Buchwald ◽

Anders Johnsson ◽

Hanna Sartor ◽

...

Keyword(s):

Lymph Nodes ◽

Anal Canal ◽

Anal Cancer ◽

Iliac Vein ◽

Target Volume ◽

Ischiorectal Fossa ◽

Pet Ct ◽

Internal Iliac ◽

Radiation Side Effects ◽

Skip Metastases

Abstract Background This study investigates the patterns of PET-positive lymph nodes (LNs) in anal cancer. The aim was to provide information that could inform future anal cancer radiotherapy contouring guidelines. Methods The baseline [18F]-FDG PET-CTs of 190 consecutive anal cancer patients were retrospectively assessed. LNs with a Deauville score (DS) of ≥3 were defined as PET-positive. Each PET-positive LN was allocated to a LN region and a LN sub-region; they were then mapped on a standard anatomy reference CT. The association between primary tumor localization and PET-positive LNs in different regions were analyzed. Results PET-positive LNs (n = 412) were identified in 103 of 190 patients (54%). Compared to anal canal tumors with extension into the rectum, anal canal tumors with perianal extension more often had inguinal (P < 0.001) and less often perirectal (P < 0.001) and internal iliac (P < 0.001) PET-positive LNs. Forty-two patients had PET-positive LNs confined to a solitary region, corresponding to first echelon nodes. The most common solitary LN region was inguinal (25 of 42; 60%) followed by perirectal (26%), internal iliac (10%), and external iliac (2%). No PET-positive LNs were identified in the ischiorectal fossa or in the inguinal area located posterolateral to deep vessels. Skip metastases above the bottom of the sacroiliac joint were quite rare. Most external iliac PET-positive LNs were located posterior to the external iliac vein; only one was located in the lateral external iliac sub-region. Conclusions The results support some specific modifications to the elective clinical target volume (CTV) in anal cancer. These changes would lead to reduced volumes of normal tissue being irradiated, which could contribute to a reduction in radiation side-effects.

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Radiation synovectomy of the knee joint

Nuklearmedizin ◽

10.1055/s-0038-1623935 ◽

2006 ◽

Vol 45 (01) ◽

pp. 57-61

Author(s):

M. Puille ◽

D. Steiner ◽

R. Bauer ◽

R. Klett

Keyword(s):

Knee Joint ◽

Lymph Nodes ◽

Geometric Mean ◽

Radiation Synovectomy ◽

Real Activity ◽

Anterior View ◽

Inguinal Lymph Nodes ◽

The Real ◽

Therapeutic Modalities ◽

Real Value

Summary Aim: Multiple procedures for the quantification of activity leakage in radiation synovectomy of the knee joint have been described in the literature. We compared these procedures considering the real conditions of dispersion and absorption using a corpse phantom. Methods: We simulated different distributions of the activity in the knee joint and a different extra-articular spread into the inguinal lymph nodes. The activity was measured with a gammacamera. Activity leakage was calculated by measuring the retention in the knee joint only using an anterior view, using the geometric mean of anterior and posterior views, or using the sum of anterior and posterior views. The same procedures were used to quantify the activity leakage by measuring the activity spread into the inguinal lymph nodes. In addition, the influence of scattered rays was evaluated. Results: For several procedures we found an excellent association with the real activity leakage, shown by an r² between 0.97 and 0.98. When the real value of the leakage is needed, e. g. in dosimetric studies, simultaneously measuring of knee activity and activity in the inguinal lymph nodes in anterior and posterior views and calculation of the geometric mean with exclusion of the scatter rays was found to be the procedure of choice. Conclusion: When measuring of activity leakage is used for dosimetric calculations, the above-described procedure should be used. When the real value of the leakage is not necessary, e. g. for comparing different therapeutic modalities, several of the procedures can be considered as being equivalent.

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