Drug delivery of anticancer agents: water soluble 4-poly (ethylene glycol) derivatives of the lignan, podophyllotoxin

In the course of this study, a series of novel, biodegradable polyanhydrides based on betulin disuccinate and dicarboxylic derivatives of poly(ethylene glycol) were prepared by two-step polycondensation. These copolymers can be used as carriers in drug delivery systems, in the form of microspheres. Betulin and its derivatives exhibit a broad spectrum of biological activity, including cytotoxic activity, which makes them promising substances for use as therapeutic agents. Microspheres that were prepared from betulin based polyanhydrides show promising properties for use in application in drug delivery systems, including inhalation systems. The obtained copolymers release the active substance—betulin disuccinate—as a result of hydrolysis under physiological conditions. The use of a poly(ethylene glycol) derivative as a co-monomer increases the solubility and bioavailability of the obtained compounds. Microspheres with diameters in the range of 0.5–25 µm were prepared by emulsion solvent evaporation method and their physicochemical and aerodynamic properties were analyzed. The morphological characteristics of the microspheres depended on the presence of poly(ethylene glycol) (PEG) segment within the structure of polyanhydrides. The porosity of the particles depended on the amount and molecular weight of the PEG used and also on the speed of homogenization. The most porous particles were obtained from polyanhydrides containing 20% wt. of PEG 600 by using a homogenization speed of 18,000 rpm.

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Application of star poly(ethylene glycol) derivatives in drug delivery and controlled release

Journal of Controlled Release ◽

10.1016/j.jconrel.2020.04.039 ◽

2020 ◽

Vol 323 ◽

pp. 565-577 ◽

Cited By ~ 2

Author(s):

Xiaobao Zhao ◽

Jingxing Si ◽

Dongsheng Huang ◽

Ke Li ◽

Ying Xin ◽

...

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Ethylene Glycol ◽

Poly Ethylene Glycol ◽

Poly Ethylene ◽

Ethylene Glycol Derivatives

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Set-up of large laboratory-scale chromatographic separations of poly(ethylene glycol) derivatives of the growth hormone-releasing factor 1–29 analogue

Journal of Chromatography A ◽

10.1016/s0021-9673(01)01367-x ◽

2002 ◽

Vol 944 (1-2) ◽

pp. 141-148 ◽

Cited By ~ 22

Author(s):

G Piquet ◽

M Gatti ◽

L Barbero ◽

S Traversa ◽

P Caccia ◽

...

Keyword(s):

Growth Hormone ◽

Ethylene Glycol ◽

Laboratory Scale ◽

Poly Ethylene Glycol ◽

Chromatographic Separations ◽

Growth Hormone Releasing Factor ◽

Poly Ethylene ◽

Ethylene Glycol Derivatives ◽

Set Up ◽

Derivatives Of

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Drug Delivery Systems: Water Soluble Taxol 2‘-Poly(ethylene glycol) Ester ProdrugsDesign andin VivoEffectiveness

Journal of Medicinal Chemistry ◽

10.1021/jm950475e ◽

1996 ◽

Vol 39 (2) ◽

pp. 424-431 ◽

Cited By ~ 167

Author(s):

Richard B. Greenwald ◽

Carl W. Gilbert ◽

Annapurna Pendri ◽

Charles D. Conover ◽

Jing Xia ◽

...

Keyword(s):

Drug Delivery ◽

Ethylene Glycol ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Water Soluble ◽

Poly Ethylene Glycol ◽

Glycol Ester ◽

Poly Ethylene

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Fabrication of poly(sarcosine), poly (ethylene glycol), and poly (lactic-co-glycolic acid) polymeric nanoparticles for cancer drug delivery

Journal of Drug Delivery Science and Technology ◽

10.1016/j.jddst.2020.102194 ◽

2020 ◽

pp. 102194

Author(s):

Sankha Bhattacharya

Keyword(s):

Drug Delivery ◽

Ethylene Glycol ◽

Glycolic Acid ◽

Polymeric Nanoparticles ◽

Cancer Drug ◽

Poly Ethylene Glycol ◽

Poly Ethylene ◽

Cancer Drug Delivery

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Synthesis and self-assembly behaviour of poly(Nα-Boc-l-tryptophan)-block-poly(ethylene glycol)-block-poly(Nα-Boc-l-tryptophan)

RSC Advances ◽

10.1039/c6ra03718f ◽

2016 ◽

Vol 6 (29) ◽

pp. 24142-24153

Author(s):

Andreea S. Voda ◽

Kevin Magniez ◽

Nisa V. Salim ◽

Cynthia Wong ◽

Qipeng Guo

Keyword(s):

Drug Delivery ◽

Ethylene Glycol ◽

Self Assembly ◽

Triblock Copolymers ◽

Potential Drug ◽

Poly Ethylene Glycol ◽

Drug Delivery Applications ◽

Poly Ethylene ◽

First Time

We report for the first time the use of Nα-Boc-l-tryptophan for the synthesis of amphiphilic BAB triblock copolymers for potential drug delivery applications.

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