Application of star poly(ethylene glycol) derivatives in drug delivery and controlled release

In this report, mixed polymeric micelles (MPMs) system self-assembled from two kinds of cholesterol-grafted amphiphilic block copolymers cholesterol modified poly ([Formula: see text]-amino esters)-grafted disulfide poly (ethylene glycol) methyl ether (PAE(-ss-mPEG)-[Formula: see text]-Chol) and poly([Formula: see text]-amino ester)-g-poly(ethylene glycol) methyl ether-cholesterol (PAE-[Formula: see text]-mPEG-Chol) were prepared for drug delivery and controlled release with pH and redox-responsibilities. The self-assembly of two block copolymers was evaluated by measurement of critical micelle concentration (CMC) values using fluorescence spectroscopy. The hydrodynamic diameter, polydispersity index (PDI) and zeta-potential of MPMs in aqueous were recorded by dynamic light scattering (DLS) at different conditions. Doxorubicin (DOX) was efficiently encapsulated in the micellar core by the hydrophobic interaction. The drug loading content (LC) and encapsulation efficacy (EE) of MPMs with different formulations were evaluated. The DOX was released due to the swelling and disassembly of MPMs induced by low pH and high glutathione (GSH) concentrations. The in vitro results demonstrated that drug release rate and cumulative release were obviously dependent on pH values and reducing agents. The results showed that the MPMs could be the potential anticancer drug delivery carriers with pH/redox-triggered drug release profile.

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Erratum to “Folate-conjugated methoxy poly(ethylene glycol)/poly(ε-caprolactone) amphiphilic block copolymeric micelles for tumor-targeted drug delivery” [Journal of Controlled Release 109 (2005) 158–168]

Journal of Controlled Release ◽

10.1016/j.jconrel.2006.01.009 ◽

2006 ◽

Vol 112 (1) ◽

pp. 145-146 ◽

Cited By ~ 2

Author(s):

Eun Kyoung Park ◽

So Yeon Kim ◽

Sang Bong Lee ◽

Young Moo Lee

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Ethylene Glycol ◽

Targeted Drug Delivery ◽

Poly Ethylene Glycol ◽

Targeted Drug ◽

Poly Ethylene

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Morphological Transitions of Photoresponsive Vesicles from Amphiphilic Polypeptoid Copolymers for Controlled Release

Polymers ◽

10.3390/polym12040798 ◽

2020 ◽

Vol 12 (4) ◽

pp. 798

Author(s):

Xu Yang ◽

Zhiwei Wang ◽

Jing Sun

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Ethylene Glycol ◽

Uv Irradiation ◽

Ring Opening ◽

Ring Opening Polymerization ◽

Poly Ethylene Glycol ◽

Morphological Transitions ◽

Poly Ethylene ◽

Copolymer Poly

Photoresponsive polymers have attracted increasing interest for a variety of applications. Here, we report a family of photoresponsive polypeptoid-based copolymer poly(ethylene glycol)-b-poly(N-(S-(o-nitrobenzyl)-thioethyl) glycine)-co-poly(N-(2-phenylethyl) glycine) (PEG-b-PNSN-co-PNPE) synthesized by the controlled ring-opening polymerization (ROP) technique. The key feature of the design is to incorporate both o-nitrobenzyl group moiety to offer the photoresponsive property and phenethyl residues to tune the structural and amphiphilic property of the system. We demonstrate that the cleavage degree of the o-nitrobenzyl group can reach to 100% upon UV-irradiation. With delicate design, a photoresponsive vesicle-to-sphere transition has been observed that facilitates the release of the encapsulants. This work provides a facile approach to prepare a type of photoresponsive polymers with tunable properties for drug delivery.

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Fabrication of poly(sarcosine), poly (ethylene glycol), and poly (lactic-co-glycolic acid) polymeric nanoparticles for cancer drug delivery

Journal of Drug Delivery Science and Technology ◽

10.1016/j.jddst.2020.102194 ◽

2020 ◽

pp. 102194

Author(s):

Sankha Bhattacharya

Keyword(s):

Drug Delivery ◽

Ethylene Glycol ◽

Glycolic Acid ◽

Polymeric Nanoparticles ◽

Cancer Drug ◽

Poly Ethylene Glycol ◽

Poly Ethylene ◽

Cancer Drug Delivery

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Controlled Release Behaviors of Ketoprofen from Matrix Polymer of Chitosan and poly(ethylene glycol)

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.813.399 ◽

2013 ◽

Vol 813 ◽

pp. 399-402

Author(s):

Chimsook Thitipha ◽

Thitiphan Chimsook

Keyword(s):

Particle Size ◽

Controlled Release ◽

Drug Release ◽

Ethylene Glycol ◽

Diffusion Method ◽

Poly Ethylene Glycol ◽

Matrix Polymer ◽

Percentage Yield ◽

Poly Ethylene ◽

Composition Ratios

The aim of present work was to prepare floating microsphere of ketoprofen using matrix polymer of chitosan and poly (ethylene glycol) by solvent diffusion method. The floating microsphere of ketoprofen was prepared from matrix polymer of chitosan and poly (ethylene glycol) with various composition ratios and evaluated such as particle size, drug compatibility and drug release of microspheres. The scanning electron microscopy of microspheres confirmed their hollow structures with smooth surface. Formulation CPK 4 to CPK 6 exhibited the best controlled release pattern in ketoprofen. The concentration and size of poly (ethylene-glycol) affected the particle size, percentage yield and drug release of microspheres.

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Synthesis and self-assembly behaviour of poly(Nα-Boc-l-tryptophan)-block-poly(ethylene glycol)-block-poly(Nα-Boc-l-tryptophan)

RSC Advances ◽

10.1039/c6ra03718f ◽

2016 ◽

Vol 6 (29) ◽

pp. 24142-24153

Author(s):

Andreea S. Voda ◽

Kevin Magniez ◽

Nisa V. Salim ◽

Cynthia Wong ◽

Qipeng Guo

Keyword(s):

Drug Delivery ◽

Ethylene Glycol ◽

Self Assembly ◽

Triblock Copolymers ◽

Potential Drug ◽

Poly Ethylene Glycol ◽

Drug Delivery Applications ◽

Poly Ethylene ◽

First Time

We report for the first time the use of Nα-Boc-l-tryptophan for the synthesis of amphiphilic BAB triblock copolymers for potential drug delivery applications.

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