1231 HEPATITIS E VIRUS: A HIDDEN DANGER IN ACUTE ON CHRONIC LIVER FAILURE

2013 ◽  
Vol 58 ◽  
pp. S499-S500 ◽  
Author(s):  
J. Borkakoti ◽  
R.K. Hazam ◽  
P. Kar
Keyword(s):  
Liver Failure ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Chronic Liver ◽  
Chronic Liver Failure

scholarly journals Role of Hepatitis E Virus Infection in Acute-on-Chronic Liver Failure

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Mario Frias ◽  
Pedro López-López ◽  
Antonio Rivero ◽  
Antonio Rivero-Juarez
Keyword(s):  
Liver Disease ◽  
Liver Failure ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Hepatic Decompensation ◽  
End Stage ◽  
The Impact

Chronic liver disease (CLD) with a variety of causes is currently reported to be one of the main causes of death worldwide. Patients with CLD experience deteriorating liver function and fibrosis, progressing to cirrhosis, chronic hepatic decompensation (CHD), end-stage liver disease (ESLD), and death. Patients may develop acute-on-chronic liver failure (ACLF), typically related to a precipitating event and associated with increased mortality. The objective of this review was to analyze the role of acute hepatitis E virus (HEV) infection in patients with CLD, focusing on the impact of this infection on patient survival and prognosis in several world regions.

scholarly journals Clinical Features of Hepatitis E Virus Infection in Ibaraki, Japan: Autochthonous Hepatitis E and Acute-on-Chronic Liver Failure

2015 ◽  
Vol 235 (4) ◽  
pp. 275-282 ◽  
Author(s):  
Yuki Inagaki ◽  
Yukio Oshiro ◽  
Naoyuki Hasegawa ◽  
Kuniaki Fukuda ◽  
Masato Abei ◽  
...  
Keyword(s):  
Virus Infection ◽  
Liver Failure ◽  
Clinical Features ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Chronic Liver ◽  
Chronic Liver Failure

Hepatitis E Virus (HEV) Infection in Cirrhotic Egyptian Patients : IgG Seroprevalence and Acute Infection in Acute-on-chronic Liver Failure

2018 ◽  
Vol 27 (4) ◽  
pp. 105-112
Author(s):  
Tash , Rehab M. El Said ◽  
Mohammad , Nana A. ◽  
Abdel-Kareem , Alaa O. ◽  
Ramadan , Raghdaa A. ◽  
Sherbini , Ahmad S.
Keyword(s):  
Liver Failure ◽  
Hepatitis E Virus ◽  
Acute Infection ◽  
Hepatitis E ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Egyptian Patients

scholarly journals Expanded Diagnostic Approach to Hepatitis E Virus Detection in Patients with Acute-on-Chronic Liver Failure: A Pilot Study

2018 ◽  
Vol 36 (3) ◽  
pp. 391-396 ◽  
Author(s):  
Runal John Steve ◽  
Fletcher John Gnanadurai ◽  
Raghavendran Anantharam ◽  
Visalakshi Jeyaseelan ◽  
Uday George Zachariah ◽  
...  
Keyword(s):  
Pilot Study ◽  
Liver Failure ◽  
Hepatitis E Virus ◽  
Virus Detection ◽  
Hepatitis E ◽  
Chronic Liver ◽  
Diagnostic Approach ◽  
Chronic Liver Failure

scholarly journals Hepatitis E virus infection in a patient with alcohol related chronic liver disease: a case report of acute-on-chronic liver failure

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Anabella Fantilli ◽  
Sarah Daniela López Villa ◽  
Alina Zerega ◽  
Guadalupe Di Cola ◽  
Luis López ◽  
...  
Keyword(s):  
Liver Disease ◽  
Virus Infection ◽  
Liver Failure ◽  
Chronic Liver Disease ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Chronic Liver ◽  
Virus Hepatitis ◽  
Chronic Liver Failure ◽  
History Of

Abstract Background The hepatitis E virus (HEV) infection has been described as a causing factor for acute-on-chronic-liver-failure (ACLF) in patients with underlying chronic liver disease (CLD), such as chronic hepatitis or cirrhosis, which could end in the failure of one or more organs and high short-term mortality. There are scarce data about the association of HEV in patients with chronic liver disorders in South America. Case presentation A 56-year-old hypertensive male with a history of type 2 diabetes was diagnosed with alcohol-related-liver cirrhosis in February 2019. A year later, the patient was admitted to hospital due to fatigue, jaundice and acholia. No evidence of hepatitis A virus, hepatitis B virus, hepatitis C virus, Epstein–Barr virus, herpes zoster virus and cytomegalovirus infections were found. Nevertheless, in February and March, 2020 the patient was positive for HEV-IgM and HEV-IgG, and HEV genotype 3 RNA was detected in sera. Afterwards, he presented grade I hepatic encephalopathy and, therefore, was diagnosed with acute hepatitis E-on-chronic liver disease. The patient reported a recent travel to the Argentine coast, where he consumed seafood. Besides, he reveled to have consumed pork meat and had no history of blood transfusion. Conclusion This report describes a unique case of hepatitis E virus infection in a patient with alcohol-related cirrhosis. This is the first report of a patient with HEV-related ACLF in Argentina and it invokes the importance of HEV surveillance and treatment among patients with CLD, such as alcohol-related cirrhosis.

Ribavirin therapy for hepatitis E virus-induced acute on chronic liver failure: a preliminary report

2012 ◽  
Vol 17 (6) ◽  
pp. 1091-1096 ◽  
Author(s):  
Rohit Goyal ◽  
Ajay Kumar ◽  
Subrat K Panda ◽  
Shashi B Paul ◽  
Subrat K Acharya
Keyword(s):  
Liver Failure ◽  
Preliminary Report ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Chronic Liver ◽  
Chronic Liver Failure

scholarly journals Acute-on-Chronic Liver Failure with Complicating Pancreatitis After Autochthonous Hepatitis E Infection

2017 ◽  
Vol 17 (11) ◽  
Author(s):  
Jack Peter ◽  
Andreas Stallmach ◽  
Andrea Tannapfel ◽  
Tony Bruns
Keyword(s):  
Liver Failure ◽  
Hepatitis E ◽  
Chronic Liver ◽  
Chronic Liver Failure

scholarly journals Immunological Manifestations of Hepatitis E-Associated Acute and Chronic Liver Failure and Its Regulatory Mechanisms

2021 ◽  
Vol 8 ◽  
Author(s):  
Jian Wu ◽  
Bai Ling ◽  
Naizhou Guo ◽  
Guanghua Zhai ◽  
Meifen Li ◽  
...  
Keyword(s):  
Liver Failure ◽  
Public Health Problem ◽  
Hepatitis E ◽  
Developed Countries ◽  
Oral Route ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Important Public Health Problem ◽  
Immunological Mechanism ◽  
Global Population

Hepatitis E virus (HEV) is a common cause of viral hepatitis in developing countries, most commonly transmitted through the fecal-oral route. The virus is mainly of genotypes (GT) 1 and GT2 genotypes, and patients usually show symptoms of acute hepatitis. Due to the rising trend of HEV serological prevalence in global population, HEV has become an important public health problem in developed countries. Severe hepatitis caused by HEV includes acute and chronic liver failure (ACLF). ACLF frequently occurs in developed countries and is caused by overlapping chronic liver diseases of HEV with genotypes GT3 and GT4. Because the onset of hepatitis E is closely associated with immunity, it is critical to understand the immunological mechanism of hepatitis E associated with acute and chronic liver failure (HEV-ACLF). This review discusses the immunological manifestations and mechanisms of HEV-ACLF, intrahepatic immune microenvironment and treatment, and raises outstanding questions about the immunological mechanism and treatment of the disease.

scholarly journals The Clinical Perspective on Hepatitis E

Viruses ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 617 ◽  
Author(s):  
Thomas Horvatits ◽  
Julian Schulze zur Wiesch ◽  
Marc Lütgehetmann ◽  
Ansgar W. Lohse ◽  
Sven Pischke
Keyword(s):  
Liver Failure ◽  
Hepatitis E ◽  
Causal Link ◽  
Chronic Liver ◽  
Genotype 1 ◽  
Genotype 3 ◽  
Chronic Liver Failure ◽  
Industrialized Nations ◽  
Life Threatening ◽  
The Tropics

Every year, there are an estimated 20 million hepatitis E virus (HEV) infections worldwide, leading to an estimated 3.3 million symptomatic cases of hepatitis E. HEV is largely circulating in the west and is associated with several hepatic and extrahepatic diseases. HEV Genotype 1 and 2 infections are waterborne and causative for epidemics in the tropics, while genotype 3 and 4 infections are zoonotic diseases and are mainly transmitted by ingestion of undercooked pork in industrialized nations. The clinical course of these infections differs: genotype 1 and 2 infection can cause acute illness and can lead to acute liver failure (ALF) or acute on chronic liver failure (ACLF) with a high mortality rate of 20% in pregnant women. In contrast, the majority of HEV GT-3 and -4 infections have a clinically asymptomatic course and only rarely lead to acute on chronic liver failure in elderly or patients with underlying liver disease. Immunosuppressed individuals infected with genotype 3 or 4 may develop chronic hepatitis E, which then can lead to life-threatening cirrhosis. Furthermore, several extra-hepatic manifestations affecting various organs have been associated with ongoing or previous HEV infections but the causal link for many of them still needs to be proven. There is no approved specific therapy for the treatment of acute or chronic HEV GT-3 or -4 infections but off-label use of ribavirin has been demonstrated to be safe and effective in the majority of patients. However, in approximately 15% of chronically HEV infected patients, cure is not possible.

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