Kappa opioid receptor stimulation decreases amphetamine-induced behavior and neuropeptide mRNA expression in the striatum

2001 ◽  
Vol 93 (1) ◽  
pp. 27-35 ◽  
Author(s):  
John A. Tzaferis ◽  
Jacqueline F. McGinty
Keyword(s):  
Mrna Expression ◽  
Opioid Receptor ◽  
Kappa Opioid Receptor ◽  
Kappa Opioid ◽  
Receptor Stimulation

Kappa-opioid peptide receptor stimulation increases cytosolic pH and myofilament responsiveness to Ca2+ in cardiac myocytes

1991 ◽  
Vol 261 (5) ◽  
pp. H1671-H1674 ◽  
Author(s):  
C. Ventura ◽  
M. C. Capogrossi ◽  
H. A. Spurgeon ◽  
E. G. Lakatta
Keyword(s):  
Cardiac Myocytes ◽  
Opioid Receptor ◽  
Kappa Opioid Receptor ◽  
Kappa Opioid ◽  
Methane Sulfonate ◽  
Receptor Stimulation ◽  
Cytosolic Ph ◽  
Prolonged Incubation ◽  
Ventricular Cells ◽  
Stimulation Of

Although kappa- and delta-opioid receptors on mammalian cardiac myocytes have been discovered recently, the intracellular effects that result from stimulation of these receptors remain unknown. We examine the effects of a rapid and brief exposure to a kappa-opioid receptor agonist on intracellular Ca2+, pH, and cell length in individual isolated rat ventricular cells. The specific kappa-agonist trans-dl-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]- benzene-acetamide (U-50488H) (methane sulfonate salt) caused a transient increase in cytosolic pH (pHi) measured from the change in SNARF-1 fluorescence and an increase in cytosolic [Ca2+] (Cai), indexed by a change in indo-1 fluorescence. The initial Cai increase often was followed by Cai oscillations. Both pHi and Cai effects were blocked by the specific antagonist kappa-opioid receptor l-(N-furylmethyl)-alpha-normetazocine methane-sulfonate (Mr 1452). The amplitude of contraction that accompanied the Cai increase elicited by U-50488H was greater than that associated with a similar increase in Cai elicited by electrical stimulation or by the rapid exposure of cells to caffeine. Thus an acute and brief kappa-opioid receptor stimulation of cardiac cells leads to an increase in Cai and pHi. The pHi increase was abolished by 1) blockade of the Na(+)-H+ exchanger by ethyl isopropyl amiloride and 2) inhibition of protein kinase C (PKC) activity via pretreatment with staurosporine or prolonged incubation with 4 beta-phorbol 12-myristate 13-acetate. These maneuvers did not abolish the U-50488H-induced increase in Ca.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: An in situ hybridization study

1994 ◽  
Vol 350 (3) ◽  
pp. 412-438 ◽  
Author(s):  
Alfred Mansour ◽  
Charles A. Fox ◽  
Sharon Burke ◽  
Fan Meng ◽  
Robert C. Thompson ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Mrna Expression ◽  
Opioid Receptor ◽  
Kappa Opioid Receptor ◽  
Hybridization Study ◽  
Kappa Opioid ◽  
Receptor Mrna ◽  
Rat Cns

New C(2)-sulfonyl ester-type Salvinorin A ligands to the kappa-opioid receptor

Planta Medica ◽  
2015 ◽  
Vol 81 (05) ◽  
Author(s):  
PR Polepally ◽  
A Keasling ◽  
K White ◽  
E Vardy ◽  
BL Roth ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Kappa Opioid Receptor ◽  
Salvinorin A ◽  
Kappa Opioid
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