scholarly journals Effects of Yishengukang decoction on expression of bone-specific alkaline phosphatase, carboxyterminal propeptide of type I procollagen, and carboxyterminal cross-linked telepeptide of type I collagen in malignant tumor patients with bone metastasis

2017 ◽  
Vol 37 (1) ◽  
pp. 30-34 ◽  
Author(s):  
Yin Yukun ◽  
Feng Li ◽  
Zhou Lei ◽  
Li Jie ◽  
Gao Yin ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Bone Metastasis ◽  
Malignant Tumor ◽  
Type I Collagen ◽  
Type I ◽  
Tumor Patients ◽  
Specific Alkaline Phosphatase ◽  
Bone Specific Alkaline Phosphatase ◽  
Type I Procollagen

scholarly journals Reduced Bone Mineral Density and Increased Bone Metabolism Rate in Young Adult Patients with 21-Hydroxylase Deficiency

2006 ◽  
Vol 91 (11) ◽  
pp. 4453-4458 ◽  
Author(s):  
Mariateresa Sciannamblo ◽  
Gianni Russo ◽  
Debora Cuccato ◽  
Giuseppe Chiumello ◽  
Stefano Mora
Keyword(s):  
Bone Mineral Density ◽  
Alkaline Phosphatase ◽  
Bone Metabolism ◽  
Type I Collagen ◽  
Whole Body ◽  
Type I ◽  
Healthy Controls ◽  
Mineral Density ◽  
Specific Alkaline Phosphatase ◽  
Bone Specific Alkaline Phosphatase

Abstract Context: Patients with congenital adrenal hyperplasia (CAH) receive glucocorticoids as replacement therapy. Glucocorticoid therapy is the most frequent cause of drug-induced osteoporosis. Objective: The objective of the study was to evaluate bone mineral density (BMD) and bone metabolism in CAH patients. Design: This was a cross-sectional observational study. Setting: The study was conducted at a referral center for pediatric endocrinology. Patients and Other Participants: Thirty young patients with the classical form of CAH (aged 16.4–29.7 yr) treated with glucocorticoid from diagnosis (duration of treatment 16.4–29.5 yr) and 138 healthy controls (aged 16.0–30.0 yr) were enrolled. Main Outcome Measures: BMD was measured in the lumbar spine and whole body by dual-energy x-ray absorptiometry. Bone formation and resorption rates were estimated by serum measurements of bone-specific alkaline phosphatase and C-terminal telopeptide of type I collagen, respectively. Results: CAH patients were shorter than controls (women −6.8 and men −13.3 cm). Therefore, several methods were used to account for the effect of this difference on bone measurements. Whole-body BMD measurements were significantly lower, compared with controls (P < 0.03), after controlling for height (on average −2.5% in females and −9.3% in male patients). No differences were found in lumbar spine measurements. Bone-specific alkaline phosphatase and C-terminal telopeptide of type I collagen serum concentrations were higher in CAH patients than control subjects (P < 0.04). BMD measurements and bone metabolism markers did not correlate with the actual glucocorticoid dose or mean dose over the previous 7 yr. Conclusions: Young adult patients with the classical form of CAH have decreased bone density values, compared with healthy controls. This may put them at risk of developing osteoporosis early in life.

scholarly journals 288 Dietary calcium decreases digestibility of phosphorus in late gestating sows, but blood biomarkers may be used to predict bone formation and resorption

2020 ◽  
Vol 98 (Supplement_3) ◽  
pp. 105-106
Author(s):  
Su A Lee ◽  
Mike R Bedford ◽  
Hans H Stein
Keyword(s):  
Bone Formation ◽  
Type I Collagen ◽  
Linear Increase ◽  
Type I ◽  
Serum Concentrations ◽  
Blood Biomarkers ◽  
Specific Alkaline Phosphatase ◽  
Bone Specific Alkaline Phosphatase ◽  
P Concentration ◽  
P Retention

Abstract The objective was to test the hypothesis that Ca levels in diets fed to late gestating sows affect apparent total tract digestibility (ATTD) and retention of Ca and P, blood Ca and P, and serum concentrations of hormones and blood biomarkers. Thirty-six sows (parity = 2.8) were divided in 3 blocks, housed individually in metabolism crates from d 91 to 105 of gestation and randomly allotted to 4 experimental diets containing 25, 50, 75, or 100% of the requirement for Ca with a constant P concentration. Fecal and urine samples were collected for 4 d after 5 d of adaptation. At the conclusion of the experiment, a blood sample from all sows was collected. The statistical model included diet as fixed effect and parity, block, and replicate within block as random effects. Values for the ATTD and retention of Ca increased quadratically (P < 0.05) as dietary Ca increased. Fecal P output increased linearly (P < 0.001) as dietary Ca increased, which resulted in a linear decrease (P < 0.001) in the ATTD of P. Urine P output decreased linearly (P < 0.001) as dietary Ca increased with a linear increase (P < 0.05) in P retention. Serum Ca and P and estrogen, calcitonin, and parathyroid hormone were not affected by dietary Ca. Carboxyterminal cross-linked telopeptide of type I collagen (CTX-I) in serum decreased linearly (P = 0.033) and bone-specific alkaline phosphatase tended to decrease linearly (P = 0.091) as Ca in diets increased. Osteocalcin in serum was not affected by Ca levels, but the ratio between osteocalcin and CTX-I tended to increase (P = 0.055) as dietary Ca increased. In conclusion, P digestibility decreases, but retention of P increases, as dietary Ca increases and blood biomarkers may be useful to predict bone formation and resorption by late gestating sows.

Sign in / Sign up

Export Citation Format

Share Document