MON-PO501: High Prevalence of Vitamin B12 Deficiency Before and Early After Gastrectomy in Patients with Gastric Cancer

2019 ◽  
Vol 38 ◽  
pp. S244
Author(s):  
M. Ao ◽  
M. Awane ◽  
Y. Asao ◽  
T. Miyawaki ◽  
K. Tanaka
Keyword(s):  
Gastric Cancer ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
High Prevalence ◽  
B12 Deficiency

P413 HIGH PREVALENCE OF VITAMIN B12 DEFICIENCY IN SAMARITAN COMMUNITY ON THE MOUNT GERIZIM

2008 ◽  
Vol 3 ◽  
pp. 204
Author(s):  
E.A. Merzon ◽  
P. Singer ◽  
R. Schneeweiss ◽  
T. Rips ◽  
E. Kitai
Keyword(s):  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
High Prevalence ◽  
B12 Deficiency

scholarly journals Défice de Vitamina B12 na Diabetes Mellitus Tipo 2

2017 ◽  
Vol 30 (10) ◽  
pp. 719
Author(s):  
Carlos Tavares Bello ◽  
Ricardo Miguel Capitão ◽  
João Sequeira Duarte ◽  
Jorge Azinheira ◽  
Carlos Vasconcelos
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Common Disease ◽  
High Prevalence ◽  
B12 Deficiency ◽  
Diabetic Population

Introduction: Type 2 diabetes mellitus is a common disease, affecting up to 13.1% of the Portuguese population. In addition to the known micro and macrovascular complications, drug side effects constitute a major concern, leading to changes in the treatment guidelines, which favor safety over efficacy. Metformin is the first-line pharmacological treatment for most patients with type 2 diabetes mellitus; however, it has been associated with vitamin B12 deficiency in up to 30% of treated patients. The authors describe the prevalence of vitamin B12 deficiency in a diabetic population and explore the possible underlying factors.Material and Methods: Retrospective, observational study. Clinical and laboratory data of type 2 diabetes mellitus patients whose vitamin B12 status was evaluated in the last decade (2005 - 2016) were analyzed. Patients with known malabsorptive syndromes or having undergone bariatric surgery were excluded from the study. Statistical analysis of the data was done and the results were considered statistically significant at p values < 0.05.Results: The study included a total of 1007 patients (58% women) with a mean age of 66.4 ± 12.2 years and 11 ± 10.4 years of type 2 diabetes mellitus duration. These patients had a high prevalence of complications: diabetic renal disease 47.7%, neuropathy 9.2%, retinopathy 14.9%, coronary artery disease 8.4%, cerebrovascular disease 10.9%, and peripheral arterial disease 5.5%. Vitamin B12 deficiency (< 174 ng / dL) was present in 21.4% of the population and this subgroup was older (68.4 vs 65.8 years, p = 0.006), had a longer type 2 diabetes mellitus duration (13.35 vs 10.36 years; p = 0.001), higher prevalence of retinopathy (20.9% vs 13.3%; p = 0.005) and thyroid dysfunction (34% vs 23.7%; p = 0.002). Vitamin B12 deficiency was also more frequent in patients treated with metformin (24.7% vs 15.8%; p = 0.017), antiplatelet agents (25.4% vs 16.2%, p < 0.001), and calcium channel blockers (26.8% vs 18.2%; p = 0.001). After adjustment for possible confounders, the variables associated with B12 deficiency were: metformin, hypothyroidism, age and type 2 diabetes mellitus duration.Discussion: Despite the retrospective design, the results report a high prevalence of vitamin B12 deficiency in the type 2 diabetic population. This study also demonstrates that the B12 deficiency risk is higher in older people, with longer diabetes mellitus duration, hypothyroidism and treated with metformin.Conclusion: Further studies are needed to identify the risk factors for the B12 deficit. The recognition of these variables will contribute to optimize the screening and prevention of the B12 deficiency in type 2 diabetes mellitus.

Compromised Vitamin B12 Status of Indian Infants and Toddlers

2020 ◽  
Vol 41 (4) ◽  
pp. 430-437
Author(s):  
Bentu Kalyan G ◽  
Medha Mittal ◽  
Rahul Jain
Keyword(s):  
Vitamin B12 ◽  
Dietary Habits ◽  
Vitamin B12 Deficiency ◽  
Infants And Toddlers ◽  
Indian Children ◽  
High Prevalence ◽  
Animal Milk ◽  
B12 Deficiency ◽  
Positive Effect ◽  
Apparently Healthy

Background: Vitamin B12 deficiency is prevalent worldwide especially in vegetarian communities. Its deficiency in early childhood may result in serious neurological and cognitive deficits. It is important to know the prevalence among our infants and toddlers so that nutritional policy changes could be suggested in this regard. Objective: To evaluate the vitamin B12 status of apparently healthy Indian children between 6 and 23 months of age. Methods: Apparently healthy Indian children (n = 210), of age 6 to 23 months, attending pediatric outpatient department were recruited and samples obtained to evaluate their hemogram and levels of vitamin B12, folate, and ferritin. Data were analyzed to obtain the mean levels and the proportion of participants deficient in vitamin B12. The dietary habits of the children were also analyzed and correlated with their vitamin B12 status. Results: Vitamin B12 deficiency was observed in 37.6% of the participants. Conclusions: There is a high prevalence of vitamin B12 deficiency in our infants and toddlers, and there is need to initiate supplement to prevent any possible neurological consequences. Early initiation of animal milk had a positive effect on the vitamin B12 status of the child, though it was not significant.

scholarly journals Perturbing Status of Vitamin B12 in Indian Infants and Their Mothers

2017 ◽  
Vol 38 (2) ◽  
pp. 209-215 ◽  
Author(s):  
Medha Mittal ◽  
Vijayashri Bansal ◽  
Rahul Jain ◽  
Pradeep Kumar Dabla
Keyword(s):  
Vitamin B12 ◽  
Early Life ◽  
Vitamin B12 Deficiency ◽  
Developing Brain ◽  
Outpatient Department ◽  
Positive Correlation ◽  
High Prevalence ◽  
B12 Deficiency ◽  
Breast Fed

Background: Vitamin B12 deficiency in early life can adversely affect the growth of developing brain with myriad of neurodevelopmental manifestations. At this age, the deficiency is usually the result of low maternal levels. Objectives: To assess the vitamin B12 status of healthy exclusively breast-fed Indian infants aged 1 to 6 months and their mothers. Methods: One hundred term exclusively breast-fed infants aged 1 to 6 months attending pediatric outpatient department were recruited. Hemogram, serum B12, folate, and ferritin levels were obtained from each infant–mother pair. Results: The prevalence of B12 deficiency in infants was found to be 57%. Forty-six percent of mothers were deficient. There was a positive correlation ( r = .23) between the B12 levels of the infants and their mothers. Conclusion: There is a high prevalence of vitamin B12 deficiency in Indian infants and their mothers. There is an urgent need to supplement our population with vitamin B12, and the best time to do this would be antenatal.

Enteral Vitamin B12 Supplementation Is Effective for Improving Anemia in Patients Who Underwent Total Gastrectomy

Oncology ◽  
2021 ◽  
pp. 1-9
Author(s):  
Tsutomu Namikawa ◽  
Masahiro Maeda ◽  
Keiichiro Yokota ◽  
Jun Iwabu ◽  
Masaya Munekage ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Vitamin B12 ◽  
Total Gastrectomy ◽  
Serum Vitamin ◽  
Vitamin B12 Deficiency ◽  
Kochi Medical School ◽  
B12 Deficiency ◽  
Red Blood Cell Count ◽  
Baseline Characteristics ◽  
Vitamin B12 Supplementation

Background: This study aimed to investigate the efficacy of enteral supplementation of vitamin B12 for vitamin B12 deficiency in patients who underwent total gastrectomy for gastric cancer. Methods: The study enrolled 133 patients who underwent total gastrectomy for gastric cancer at Kochi Medical School. Clinical data were obtained to investigate associations between vitamin B12 supplementation and vitamin B12 levels. Vitamin B12 deficiency was defined as serum vitamin B12 less than 200 pg/mL. Baseline characteristics and changes in hematological variables, including vitamin B12 levels, were examined. Results: Vitamin B12 deficiency was present in 71.4% of the 133 patients. Vitamin B12 levels at 3, 6, and 12 months after enteral supplementation were 306 pg/mL, 294 pg/mL, and 367 pg/mL, respectively, which were all significantly higher than those before supplementation (p < 0.001 for all comparisons). The median red blood cell count at 3, 6, and 12 months after enteral supplementation were 380 × 104/mm3, 394 × 104/mm3, and 395 × 104/mm3, respectively, which were all significantly higher than those before supplementation (p = 0.020, p = 0.001, and p = 0.003, respectively). Vitamin B12 levels at 3, 6, and 12 months after supplementation were significantly higher in patients supplemented enterally than those supplemented parenterally (p < 0.001 for all comparisons). Conclusions: Vitamin B12 deficiency was found in 71.4% of postoperative patients who underwent total gastrectomy for gastric cancer, and enteral vitamin B12 supplements might be effective to improve anemia in these patients.

Per oral vitamin B12 replacement therapy after gastrectomy and its optimal dose (retrospective study) and our protocol of a prospective clinical trial.

2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 338-338
Author(s):  
Yasushi Rino ◽  
Toru Aoyama ◽  
Norio Yukawa ◽  
Haruhiko Cho ◽  
Takashi Oshima ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Clinical Trial ◽  
Vitamin B12 ◽  
Replacement Therapy ◽  
Total Gastrectomy ◽  
Initial Treatment ◽  
Vitamin B12 Deficiency ◽  
Oral Vitamin ◽  
B12 Deficiency ◽  
Per Oral

338 Background: Postgastrectomy vitamin B12 deficiency is common metabolic sequel and worsens the quality of life of gastric cancer survivors. Recently, oral vitamin B12 replacement is reported. Therefore, we investigated retrospectively the efficacy of oral vitamin B12 replacement for gastric cancer patients with vitamin B12 deficiency after total gastrectomy. Methods: We reviewed 73 patients with gastric cancer who underwent total gastrectomy and were treated vitamin B12 replacement. Patients were consisted of 56 males and 17 females and median age was 70 y/o. We investigated initial treatment of vitamin B12 replacement and improvement of vitamin B12 deficiency. Results: Initial treatment of vitamin B12 replacements were intramuscular injection for 42 patients, per oral replacement for 28 patients and intravenous injection for 3 patients. Finally, all patients were treated with per oral replacement and the serum vitamin B12 levels became within normal range. Final vitamin B12 doses of replacement therapy were 500 µg of 20 out of 73 pts, respectively. Conclusions: Vitamin B12 replacement therapy should be necessary and continued. According to our results, one vitamin B12 tablet a day is enough. The vitamin B12 deficiency symptoms could be prevented. 500 micrograms vitamin B12 replacement orally is maybe effective and necessary. Our prospective clinical protocol (UMIN000030727): In this study, an oral vitamin B12 preparation (1500 μg/day, administered daily) was set as the control treatment, and a specific clinical trial was started to determine whether 500 μg/day daily administration would be sufficient for replacement therapy. Clinical trial information: UMIN000030727.

Déficit de vitamina B12 en grupos vulnerables con alimentación omnívora

2021 ◽  
Vol 22 (3) ◽  
Author(s):  
Isabel Bianchi di Carcano ◽  
◽  
Marisa Armeno
Keyword(s):  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Public Health Problem ◽  
Social Situation ◽  
Therapeutic Interventions ◽  
Weekly Dose ◽  
High Prevalence ◽  
B12 Deficiency ◽  
Women And Children ◽  
Timely Treatment

Introduction: vitamin B12 plays an essential role in growth and neurodevelopment. Vitamin B12 deficiency is a public health problem in Argentina, with a high prevalence in a highrisk population, such as pregnant women and children with a vulnerable social situation, although their omnivorous diet. Objectives: to update the information available on vitamin B12 deficiency in vulnerable populations, in order to highlight the importance of the subject, to achieve an early diagnosis and timely treatment and thus prevent irreversible complications. Results: it is important that the pediatrician knows the different types of vitamin B12 deficiency presentation and to consider it as a differential diagnosis in children with neurological symptoms, even in the absence of anemia, to achieve early interventions and diminish the burden of disease. Many researchers have concluded that an isolated marker can lead to misdiagnoses, so it is currently recommended to use at least two. Most of the treatments evaluated, agree on the administration of 1 mg of B12, for 7 to 10 days, either intramuscular or orally, followed by 3 to 11 weeks of a weekly dose. Conclusions: it is important to update data on the prevalence of B12 deficiency in our country, as well as the implementation of therapeutic interventions and preventive public policies.

Vitamin B12 Deficiency After Gastrectomy for Gastric Cancer

2013 ◽  
Vol 258 (6) ◽  
pp. 970-975 ◽  
Author(s):  
Yanfeng Hu ◽  
Hyoung-Il Kim ◽  
Woo Jin Hyung ◽  
Ki Jun Song ◽  
Joong Ho Lee ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
B12 Deficiency
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