Histologic observation of soft tissue responses to implanted, multifaceted particles and discs of hydroxylapatite

1984 ◽  
Vol 42 (3) ◽  
pp. 143-149 ◽  
Author(s):  
Hans P. Drobeck ◽  
Sanford S. Rothstein ◽  
Kenneth I. Gumaer ◽  
Alfred D. Sherer ◽  
Ralph G. Slighter
Keyword(s):  
Soft Tissue ◽  
Tissue Responses

Soft Tissue Responses and Attachment to Porous Titanium with Different Surface Characteristics

2006 ◽  
Vol 9 (2) ◽  
pp. 127-134
Author(s):  
Yao Wu ◽  
Hu Li ◽  
Tun Yuan ◽  
Chunlin Deng ◽  
Bangcheng Yang ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Surface Characteristics ◽  
Porous Titanium ◽  
Tissue Responses

The clinical impact of bone scan (BS) flare with enzalutamide (ENZA) in men with metastatic castration-resistant prostate cancer (mCRPC).

2019 ◽  
Vol 37 (7_suppl) ◽  
pp. 183-183
Author(s):  
Andrew J. Armstrong ◽  
Mohammed Al-Adhami ◽  
Ping Lin ◽  
Teresa Parli ◽  
Jennifer Sugg ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Clinical Impact ◽  
Adverse Outcomes ◽  
Bone Lesions ◽  
Castration Resistant Prostate Cancer ◽  
Two Phase ◽  
Castration Resistant ◽  
Slow Progression ◽  
Tissue Responses

183 Background: Current PCWG3 guidelines for men with mCRPC define BS progression during therapy as requiring confirmation of new bone lesions that develop over time with additional new lesions. New unconfirmed BS lesions may reflect slow progression or a favorable osteoblastic reaction called a “BS flare” that can be misinterpreted as radiographic progression and lead to premature therapy discontinuation. The prevalence and clinical impact of BS flare is unknown for ENZA. Methods: We analyzed the association of BS flare with clinical outcomes and quality of life (QoL) in a retrospective analysis of two phase 3 trials of men with mCRPC treated with ENZA after (AFFIRM n = 1199) and before (PREVAIL n = 1717) docetaxel. Early and late BS flare was defined as new lesions on the first posttreatment BS (weeks 9-13) or subsequent BS, respectively, that were not confirmed to meet progression criteria on the next BS, while also requiring responding/stable PSA and soft-tissue disease. Results: Unconfirmed BS lesions were observed in 22% and 25% of stable/responding men receiving ENZA in AFFIRM and PREVAIL, respectively. Most BS flares were early, but late flares (week 17 or later) were seen in 2% and 13% of men, respectively. Unconfirmed BS lesions (early or late) had no impact on OS (HR 0.87; 95% CI 0.62-1.21) or rPFS (HR 0.91; 95% CI 0.58-1.44) in PREVAIL, but were associated with worse OS (HR 2.26; 95% CI 1.55-3.30) and rPFS (HR 1.73; 95% CI 1.33-2.26) in AFFIRM. Soft-tissue responses and PSA declines were more prominent in chemo-naïve men with unconfirmed BS lesions, which also had no impact on QoL or pain deterioration in either setting. Conclusions: BS flare occurred in ≈25% of responding men with mCRPC receiving ENZA and was not associated with adverse outcomes in chemo-naïve men. Our findings support the importance of avoiding premature treatment discontinuation in the presence of unconfirmed new BS lesions in the first 4 months of therapy. Worse outcomes associated with unconfirmed lesions in men post docetaxel illustrate the need for improved functional bone imaging in mCRPC and broader patient assessment to decide on treatment continuation. Clinical trial information: NCT00974311; NCT01212991.

scholarly journals In vivo soft tissue compressive properties of the human hand

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261008
Author(s):  
Victoria Spartacus ◽  
Maedeh Shojaeizadeh ◽  
Vincent Raffault ◽  
James Shoults ◽  
Ken Van Wieren ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Upper Extremity ◽  
Loading Rate ◽  
Tissue Response ◽  
Peak Force ◽  
Joint Position ◽  
Tissue Thickness ◽  
Damping Characteristics ◽  
Tissue Responses

Background/Purpose Falls onto outstretched hands are the second most common sports injury and one of the leading causes of upper extremity injury. Injury risk and severity depends on forces being transmitted through the palmar surface to the upper extremity. Although the magnitude and distribution of forces depend on the soft tissue response of the palm, the in vivo properties of palmar tissue have not been characterized. The purpose of this study was to characterize the large deformation palmar soft tissue properties. Methods In vivo dynamic indentations were conducted on 15 young adults (21–29 years) to quantify the soft tissue characteristics of over the trapezium. The effects of loading rate, joint position, tissue thickness and sex on soft tissue responses were assessed. Results Energy absorbed by the soft tissue and peak force were affected by loading rate and joint angle. Energy absorbed was 1.7–2.8 times higher and the peak force was 2–2.75 times higher at high rate loading than quasistatic rates. Males had greater energy absorbed than females but not at all wrist positions. Damping characteristics were the highest in the group with the thickest soft tissue while damping characteristics were the lowest in group with the thinnest soft tissues. Conclusion Palmar tissue response changes with joint position, loading rate, sex, and tissue thickness. Accurately capturing these tissue responses is important for developing effective simulations of fall and injury biomechanics and assessing the effectiveness of injury prevention strategies.

Comparative Soft and Hard Tissue Responses to Titanium and Polymer Healing Abutments

2011 ◽  
Vol 37 (sp1) ◽  
pp. 174-182 ◽  
Author(s):  
Theofilos Koutouzis ◽  
Joseph Richardson ◽  
Tord Lundgren
Keyword(s):  
Soft Tissue ◽  
Prospective Trial ◽  
Material Composition ◽  
Limited Information ◽  
Hard Tissue ◽  
Tissue Responses ◽  
Bone Level ◽  
Marginal Bone Level

Limited information exists regarding soft tissue and hard tissue responses to abutments with different material composition. The aim of this study is to evaluate soft and hard tissue responses to titanium and polymer healing abutments over a 3-month period. Sixteen patients were included in this prospective trial. Implants were provisionalized with either titanium or polymer healing abutments. Changes of marginal bone level and soft tissue dimensions were recorded at implant installation and at 3 months.

scholarly journals The Correlation between Follow-up MRI Findings and Laboratory Results in Pyogenic Spondylodiscitis

2020 ◽  
Author(s):  
Kyung-Sik Ahn ◽  
Chang Ho Kang ◽  
Suk-Joo Hong ◽  
Baek Hyun Kim ◽  
Euddeum Shim
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Imaging Method ◽  
Mri Findings ◽  
Pyogenic Spondylodiscitis ◽  
Tissue Responses ◽  
Laboratory Results ◽  
Tissue Changes ◽  
Soft Tissue Changes

Abstract Background Although MRI is the gold-standard imaging method in the diagnosis of spondylodiscitis, role of follow-up imaging is debated and there can be discrepancies with regard to the significance of bony or soft tissue responses to treatment. Purpose of our study is to test whether the MRI changes on follow-up imaging correlate with laboratory findings of treatment response. Methods A total of 48 patients with pyogenic spondylodiscitis who underwent baseline and follow-up MRI were retrospectively reviewed. The extent of bone marrow edema, paravertebral soft tissue inflammation, and disc height were compared on baseline and follow-up MRIs with the C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels obtained from the medical records at baseline and on follow-up. Relationships between the MRI and laboratory changes were analyzed using the Spearmann correlation test. Results The mean MRI follow-up period was 42.25 days. Based on the CRP (resolved: n=19, resolving: n=19, and aggravated: n=10), there was significant correlation between the laboratory results and the changes in the bone and soft tissues (p < 0.01, both). The correlation was best with soft tissue changes (rho: 0.48) followed by bony changes (rho: 0.41). Based on the ESR (resolved: n=8, resolving: n=22, and worsened: n=18), the correlation was stronger with bone changes (rho: 0.45, p < 0.01) than it was with soft tissue changes (rho: 0.39, p = 0.01). Conclusion Follow-up MRI findings of pyogenic spondylodiscitis show variable tissue responses. CRP was best correlated with soft tissue changes, while ESR showed the best association with bony changes.

scholarly journals Soft tissue responses to differential shapes of the implant abutment

2006 ◽  
Vol 36 (1) ◽  
pp. 167
Author(s):  
Soo-Yong Ahn ◽  
Chong-Hyun Han ◽  
Seong-Joo Heo ◽  
Tae-Il Kim ◽  
Yang-Jo Seol ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Tissue Responses ◽  
Implant Abutment

scholarly journals Unpredictability of soft tissue changes after camouflage treatment of Class II division 1 malocclusion with maximum anterior retraction using miniscrews

2016 ◽  
Vol 87 (2) ◽  
pp. 230-238 ◽  
Author(s):  
Kayoung Kim ◽  
Sung-Hwan Choi ◽  
Eun-Hee Choi ◽  
Yoon-Jeong Choi ◽  
Chung-Ju Hwang ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Class Ii ◽  
Maxillary Incisor ◽  
Upper Lip ◽  
Lower Lip ◽  
Anterior Teeth ◽  
Division 1 ◽  
Tissue Responses ◽  
Incisor Retraction ◽  
Maximum Group

ABSTRACT Objective: To compare soft and hard tissue responses based on the degree of maxillary incisor retraction using maximum anchorage in patients with Class II division 1 malocclusion. Materials and Methods: This retrospective study sample was divided into moderate retraction (&lt;8.0 mm; n = 28) and maximum retraction (≥8.0 mm; n = 29) groups based on the amount of maxillary incisor retraction after extraction of the maxillary and mandibular first premolars for camouflage treatment. Pre- and posttreatment lateral cephalograms were analyzed. Results: There were 2.3 mm and 3.0 mm of upper and lower lip retraction, respectively, in the moderate group; and 4.0 mm and 5.3 mm, respectively, in the maximum group. In the moderate group, the upper lip was most influenced by posterior movement of the cervical point of the maxillary incisor (β = 0.94). The lower lip was most influenced by posterior movement of B-point (β = 0.84) and the cervical point of the mandibular incisor (β = 0.83). Prediction was difficult in the maximum group; no variable showed a significant influence on upper lip changes. The lower lip was highly influenced by posterior movement of the cervical point of the maxillary incisor (β = 0.50), but this correlation was weak in the maximum group. Conclusions: Posterior movement of the cervical point of the anterior teeth is necessary for increased lip retraction. However, periodic evaluation of the lip profile is needed during maximum retraction of the anterior teeth because of limitations in predicting soft tissue responses.

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