Soft Tissue Responses and Attachment to Porous Titanium with Different Surface Characteristics

183 Background: Current PCWG3 guidelines for men with mCRPC define BS progression during therapy as requiring confirmation of new bone lesions that develop over time with additional new lesions. New unconfirmed BS lesions may reflect slow progression or a favorable osteoblastic reaction called a “BS flare” that can be misinterpreted as radiographic progression and lead to premature therapy discontinuation. The prevalence and clinical impact of BS flare is unknown for ENZA. Methods: We analyzed the association of BS flare with clinical outcomes and quality of life (QoL) in a retrospective analysis of two phase 3 trials of men with mCRPC treated with ENZA after (AFFIRM n = 1199) and before (PREVAIL n = 1717) docetaxel. Early and late BS flare was defined as new lesions on the first posttreatment BS (weeks 9-13) or subsequent BS, respectively, that were not confirmed to meet progression criteria on the next BS, while also requiring responding/stable PSA and soft-tissue disease. Results: Unconfirmed BS lesions were observed in 22% and 25% of stable/responding men receiving ENZA in AFFIRM and PREVAIL, respectively. Most BS flares were early, but late flares (week 17 or later) were seen in 2% and 13% of men, respectively. Unconfirmed BS lesions (early or late) had no impact on OS (HR 0.87; 95% CI 0.62-1.21) or rPFS (HR 0.91; 95% CI 0.58-1.44) in PREVAIL, but were associated with worse OS (HR 2.26; 95% CI 1.55-3.30) and rPFS (HR 1.73; 95% CI 1.33-2.26) in AFFIRM. Soft-tissue responses and PSA declines were more prominent in chemo-naïve men with unconfirmed BS lesions, which also had no impact on QoL or pain deterioration in either setting. Conclusions: BS flare occurred in ≈25% of responding men with mCRPC receiving ENZA and was not associated with adverse outcomes in chemo-naïve men. Our findings support the importance of avoiding premature treatment discontinuation in the presence of unconfirmed new BS lesions in the first 4 months of therapy. Worse outcomes associated with unconfirmed lesions in men post docetaxel illustrate the need for improved functional bone imaging in mCRPC and broader patient assessment to decide on treatment continuation. Clinical trial information: NCT00974311; NCT01212991.

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Surface Properties, Efficacy and Biological Responses to Biomaterials

MRS Proceedings ◽

10.1557/proc-110-313 ◽

1987 ◽

Vol 110 ◽

Author(s):

J. E. Lemons

Keyword(s):

Surface Properties ◽

Porous Titanium ◽

Bulk Properties ◽

Synthetic Materials ◽

Biological Responses ◽

Surgical Implants ◽

Tissue Responses ◽

Device Applications ◽

Materials Used ◽

Cobalt Base

AbstractBiological responses to synthetic materials used for the construction of surgical implants often determine device longevities. Over the past two decades, individuals from basic and applied disciplines have attempted to better understand the phenomena associated with biomaterial to tissue interfaces and to better control the surface and bulk properties of the synthetic substances for each area of device applications. Surface properties of metals, polymers, ceramics and composites are reviewed and where possible, correlated with tissue responses. Specific examples of solid and porous titanium and cobalt base alloys are presented to demonstrate the importance of surface and bulk properties with respect to biocompatibility.

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An evaluation of soft tissue responses following removal of ill-fitting dentures

Journal of Prosthetic Dentistry ◽

10.1016/0022-3913(80)90397-2 ◽

1980 ◽

Vol 43 (3) ◽

pp. 251-253 ◽

Cited By ~ 2

Author(s):

Bennie S. Dukes

Keyword(s):

Soft Tissue ◽

Tissue Responses

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Histologic observation of soft tissue responses to implanted, multifaceted particles and discs of hydroxylapatite

Journal of Oral and Maxillofacial Surgery ◽

10.1016/s0278-2391(84)80024-5 ◽

1984 ◽

Vol 42 (3) ◽

pp. 143-149 ◽

Cited By ~ 92

Author(s):

Hans P. Drobeck ◽

Sanford S. Rothstein ◽

Kenneth I. Gumaer ◽

Alfred D. Sherer ◽

Ralph G. Slighter

Keyword(s):

Soft Tissue ◽

Tissue Responses

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In vivo soft tissue compressive properties of the human hand

PLoS ONE ◽

10.1371/journal.pone.0261008 ◽

2021 ◽

Vol 16 (12) ◽

pp. e0261008

Author(s):

Victoria Spartacus ◽

Maedeh Shojaeizadeh ◽

Vincent Raffault ◽

James Shoults ◽

Ken Van Wieren ◽

...

Keyword(s):

Soft Tissue ◽

Upper Extremity ◽

Loading Rate ◽

Tissue Response ◽

Peak Force ◽

Joint Position ◽

Tissue Thickness ◽

Damping Characteristics ◽

Tissue Responses

Background/Purpose Falls onto outstretched hands are the second most common sports injury and one of the leading causes of upper extremity injury. Injury risk and severity depends on forces being transmitted through the palmar surface to the upper extremity. Although the magnitude and distribution of forces depend on the soft tissue response of the palm, the in vivo properties of palmar tissue have not been characterized. The purpose of this study was to characterize the large deformation palmar soft tissue properties. Methods In vivo dynamic indentations were conducted on 15 young adults (21–29 years) to quantify the soft tissue characteristics of over the trapezium. The effects of loading rate, joint position, tissue thickness and sex on soft tissue responses were assessed. Results Energy absorbed by the soft tissue and peak force were affected by loading rate and joint angle. Energy absorbed was 1.7–2.8 times higher and the peak force was 2–2.75 times higher at high rate loading than quasistatic rates. Males had greater energy absorbed than females but not at all wrist positions. Damping characteristics were the highest in the group with the thickest soft tissue while damping characteristics were the lowest in group with the thinnest soft tissues. Conclusion Palmar tissue response changes with joint position, loading rate, sex, and tissue thickness. Accurately capturing these tissue responses is important for developing effective simulations of fall and injury biomechanics and assessing the effectiveness of injury prevention strategies.

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Surface characteristics of porous titanium implants fabricated by environmental electro-discharge sintering of spherical Ti powders in a vacuum atmosphere

Scripta Materialia ◽

10.1016/j.scriptamat.2005.06.033 ◽

2005 ◽

Vol 53 (8) ◽

pp. 905-908 ◽

Cited By ~ 19

Author(s):

Y.B. An ◽

N.H. Oh ◽

Y.W. Chun ◽

Y.H. Kim ◽

J.S. Park ◽

...

Keyword(s):

Surface Characteristics ◽

Porous Titanium ◽

Titanium Implants ◽

Vacuum Atmosphere

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Comparative Soft and Hard Tissue Responses to Titanium and Polymer Healing Abutments

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-09-00102.1 ◽

2011 ◽

Vol 37 (sp1) ◽

pp. 174-182 ◽

Cited By ~ 40

Author(s):

Theofilos Koutouzis ◽

Joseph Richardson ◽

Tord Lundgren

Keyword(s):

Soft Tissue ◽

Prospective Trial ◽

Material Composition ◽

Limited Information ◽

Hard Tissue ◽

Tissue Responses ◽

Bone Level ◽

Marginal Bone Level

Limited information exists regarding soft tissue and hard tissue responses to abutments with different material composition. The aim of this study is to evaluate soft and hard tissue responses to titanium and polymer healing abutments over a 3-month period. Sixteen patients were included in this prospective trial. Implants were provisionalized with either titanium or polymer healing abutments. Changes of marginal bone level and soft tissue dimensions were recorded at implant installation and at 3 months.

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The Correlation between Follow-up MRI Findings and Laboratory Results in Pyogenic Spondylodiscitis

10.21203/rs.3.rs-16286/v1 ◽

2020 ◽

Author(s):

Kyung-Sik Ahn ◽

Chang Ho Kang ◽

Suk-Joo Hong ◽

Baek Hyun Kim ◽

Euddeum Shim

Keyword(s):

Soft Tissue ◽

Soft Tissues ◽

Imaging Method ◽

Mri Findings ◽

Pyogenic Spondylodiscitis ◽

Tissue Responses ◽

Laboratory Results ◽

Tissue Changes ◽

Soft Tissue Changes

Abstract Background Although MRI is the gold-standard imaging method in the diagnosis of spondylodiscitis, role of follow-up imaging is debated and there can be discrepancies with regard to the significance of bony or soft tissue responses to treatment. Purpose of our study is to test whether the MRI changes on follow-up imaging correlate with laboratory findings of treatment response. Methods A total of 48 patients with pyogenic spondylodiscitis who underwent baseline and follow-up MRI were retrospectively reviewed. The extent of bone marrow edema, paravertebral soft tissue inflammation, and disc height were compared on baseline and follow-up MRIs with the C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels obtained from the medical records at baseline and on follow-up. Relationships between the MRI and laboratory changes were analyzed using the Spearmann correlation test. Results The mean MRI follow-up period was 42.25 days. Based on the CRP (resolved: n=19, resolving: n=19, and aggravated: n=10), there was significant correlation between the laboratory results and the changes in the bone and soft tissues (p < 0.01, both). The correlation was best with soft tissue changes (rho: 0.48) followed by bony changes (rho: 0.41). Based on the ESR (resolved: n=8, resolving: n=22, and worsened: n=18), the correlation was stronger with bone changes (rho: 0.45, p < 0.01) than it was with soft tissue changes (rho: 0.39, p = 0.01). Conclusion Follow-up MRI findings of pyogenic spondylodiscitis show variable tissue responses. CRP was best correlated with soft tissue changes, while ESR showed the best association with bony changes.

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