Simultaneous sterno-thoracic cardiopulmonary resuscitation improves short-term survival rate in canine cardiac arrests

Resuscitation ◽  
2002 ◽  
Vol 53 (2) ◽  
pp. 209-216 ◽  
Author(s):  
Sung Oh Hwang ◽  
Kang Hyun Lee ◽  
Jin Woong Lee ◽  
Seo Young Lee ◽  
Byung Su Yoo ◽  
...  
Keyword(s):  
Survival Rate ◽  
Cardiopulmonary Resuscitation ◽  
Short Term ◽  
Term Survival ◽  
Short Term Survival

Effect of positive end-expiratory pressure during cardiopulmonary resuscitation on short-term survival

Resuscitation ◽  
2019 ◽  
Vol 142 ◽  
pp. e7-e8
Author(s):  
Christophe Duchatelet ◽  
Martha Wolfskeil ◽  
Maxim Vanwulpen ◽  
Said-Hachimi Idrissi
Keyword(s):  
Cardiopulmonary Resuscitation ◽  
Positive End Expiratory Pressure ◽  
Short Term ◽  
Term Survival ◽  
Short Term Survival

scholarly journals Short-Term Survival and Safety of Apatinib Combined With Oxaliplatin and S-1 in the Conversion Therapy of Unresectable Gastric Cancer

2021 ◽  
Author(s):  
Zaisheng Ye ◽  
Yi Zeng ◽  
Shenghong Wei ◽  
Yi Wang ◽  
Zhitao Lin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Survival Rate ◽  
Objective Response ◽  
Radical Resection ◽  
R0 Resection ◽  
Conversion Therapy ◽  
Short Term ◽  
Term Survival ◽  
Unresectable Gastric Cancer ◽  
Short Term Survival

Abstract BackgroundTo investigate the short-term efficacy and safety of apatinib combined with oxaliplatin and S-1 in the treatment of unresectable gastric cancer.Patients and methodsPreviously untreated patients with unresectable HER-2-negative advanced gastric cancer were selected. All the patients received six cycles of S-1 and oxaliplatin and five cycles of apatinib, which were administered at intervals of three weeks. The surgery was performed after six cycles of drug treatment. The primary endpoints were radical resection (R0) rate and safety. This study was registered with the China Trial Register, number ChiCTR-ONC-17010430(01/12/2016-01/12/2022).ResultsA total of 39 patients were enrolled. Efficacy evaluation was feasible for 37 patients. One patient achieved complete response (CR, 2.7%), 26 patients achieved partial response (PR, 70.3%), three patients had stable disease (SD, 8.1%) and seven patients had progressive disease (PD, 18.9%). The objective response rate (ORR) was 73.0% and the disease control rate (DCR) was 81.1%. 22 patients underwent surgery, among which 14 patients underwent radical resection (R0), with a R0 resection rate of 63.6%. The 1-year survival rate of the surgical group (22 patients) was 71.1% and the 2-year survival rate was 41.1%. The median survival time was 21 months. The incidence of adverse reactions (AEs) was 100%. Leucopenia (65.3%) and granulocytopenia (69.2%) were the most common hematological AEs. The most common non-hematological AEs were fatigue (51.3%) and oral mucositis (35.9%).ConclusionApatinib combined with oxaliplatin and S-1 showed good short-term survival and acceptable safety in the conversion therapy of unresectable gastric cancer.

Abstract WP260: Pravastatin Improves Short-term Survival Rate Following Cardiac Arrest and Cardiopulumonary Resuscitation In Mice

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Shin Nakayama ◽  
Noriko Taguchi ◽  
Makoto Tanaka
Keyword(s):  
Body Weight ◽  
Cardiac Arrest ◽  
Survival Rate ◽  
Neuronal Damage ◽  
Pleiotropic Effects ◽  
Histological Evaluation ◽  
Vehicle Group ◽  
Short Term ◽  
Term Survival ◽  
Short Term Survival

Statins (HMG-CoA reductase inhibitors) exert numerous pleiotropic effects and have been shown to attenuate ischemic injury in different rodent models of cerebral focal ischemia. Few studies have examined the effect of statins on post cardiac arrest syndrome. This study conducted cardiac arrest and cardiopulmonary resuscitation (CA/CPR) in mice and tested the hypothesis that intravenous statin after CPR improves survival rate and neurological outcomes. Methods: Adult male mice (20-26 g) were subjected to CA induced by intravenous (IV) KCL. After 8 min of CA, CPR was initiated with IV epinephrine, ventilation with 100% oxygen and chest compressions (rate 300/min). At 1 hr after return of spontaneous circulation, mice were treated with either IV injection of pravastatin (3mg/kg) or vehicle. Four days after CA/CPR, neurobehavioral assessments were performed and brains were removed for histological evaluation in hippocampus and caudateputamen. Results: No difference was found between two groups in body weight, duration of CPR and dose of epinephrine. Survival rate at 4 days after CPR was significantly higher in pravastatin group compared with vehicle group (66.7%; n=24 vs 48.4%; n=33). Neurobehavioral scores in pravastatin group were better than vehicle group at 2 to 4 days after CPR. Body weight loss in vehicle group at 4 days after CPR was higher than pravastatin group (-19.4±1.8% vs -13.4±2.0%), which indicates loss of feeding activity. Histological damages in hippocampus and caudateputamen were not statistically different between two groups (pravastatin: 23.8±7.0% vs vehicle: 35.2±9.2% in hippocampus) (pravastatin: 49.4±7.2% vs vehicle: 60.5±7.8% in caudateputamen). All values are presented as mean±SEM. Conclusions: Single IV injection of pravastatin after CA improved short-term survival and neurobehavioral score in the mouse experimental CA model. Neuronal damage in the brain region was comparable to vehicle group. These data suggest that pravastatin given after CA would be beneficial in the post resuscitation phase via systemic pleiotropic effects such as anti inflammatory response and improved vascular reactivity.

scholarly journals Short-term survival and safety of apatinib combined with oxaliplatin and S-1 in the conversion therapy of unresectable gastric cancer

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zaisheng Ye ◽  
Yi Zeng ◽  
Shenghong Wei ◽  
Yi Wang ◽  
Zhitao Lin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Survival Rate ◽  
Objective Response ◽  
Radical Resection ◽  
R0 Resection ◽  
Conversion Therapy ◽  
Short Term ◽  
Term Survival ◽  
Unresectable Gastric Cancer ◽  
Short Term Survival

Abstract Background We conducted a single-arm phase II trial to investigate the short-term efficacy and safety of apatinib combined with oxaliplatin and S-1 in the treatment of unresectable gastric cancer. Patients and methods Previously untreated patients with unresectable HER-2-negative advanced gastric cancer were selected. All the patients received six cycles of S-1 and oxaliplatin and five cycles of apatinib, which were administered at intervals of three weeks. The surgery was performed after six cycles of drug treatment. The primary endpoints were radical resection (R0) rate and safety. This study was registered with the China Trial Register, number ChiCTR-ONC-17010430 (01/12/2016–01/12/2022). Results A total of 39 patients were enrolled. Efficacy evaluation was feasible for 37 patients. One patient achieved complete response (CR, 2.7%), 26 patients achieved partial response (PR, 70.3%), three patients had stable disease (SD, 8.1%) and seven patients had progressive disease (PD, 18.9%). The objective response rate (ORR) was 73.0% and the disease control rate (DCR) was 81.1%. 22 patients underwent surgery, among which 14 patients underwent radical resection (R0), with a R0 resection rate of 63.6%. The 1-year survival rate of the surgical group (22 patients) was 71.1% and the 2-year survival rate was 41.1%. The median survival time was 21 months. The incidence of adverse events (AEs) was 100%. Leucopenia (65.3%) and granulocytopenia (69.2%) were the most common hematological AEs. The most common non-hematological AEs were fatigue (51.3%) and oral mucositis (35.9%). Conclusion Apatinib combined with oxaliplatin and S-1 showed good short-term survival and acceptable safety in the conversion therapy of unresectable gastric cancer.

scholarly journals Use of an end-tidal carbon dioxide-guided algorithm during cardiopulmonary resuscitation improves short-term survival in paediatric swine

2021 ◽  
Vol 8 ◽  
pp. 100174
Author(s):  
Caitlin E. O'Brien ◽  
Polan T. Santos ◽  
Ewa Kulikowicz ◽  
Shawn Adams ◽  
Jennifer K. Lee ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Cardiopulmonary Resuscitation ◽  
Short Term ◽  
Term Survival ◽  
End Tidal Carbon Dioxide ◽  
End Tidal ◽  
Short Term Survival

scholarly journals Hemodynamic Directed Cardiopulmonary Resuscitation Improves Short-Term Survival From Ventricular Fibrillation Cardiac Arrest*

2013 ◽  
Vol 41 (12) ◽  
pp. 2698-2704 ◽  
Author(s):  
Stuart H. Friess ◽  
Robert M. Sutton ◽  
Utpal Bhalala ◽  
Matthew R. Maltese ◽  
Maryam Y. Naim ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Ventricular Fibrillation ◽  
Cardiopulmonary Resuscitation ◽  
Short Term ◽  
Term Survival ◽  
Short Term Survival

Evaluation of An End-Tidal CO2 Detector During Pediatric Cardiopulmonary Resuscitation

PEDIATRICS ◽  
1995 ◽  
Vol 95 (3) ◽  
pp. 395-399
Author(s):  
Mananda S. Bhende ◽  
Ann E. Thompson
Keyword(s):  
Cardiopulmonary Resuscitation ◽  
Predictive Value ◽  
Life Support ◽  
Color Change ◽  
Spontaneous Circulation ◽  
Short Term ◽  
Term Survival ◽  
End Tidal ◽  
End Tidal Co2 ◽  
Short Term Survival

Objective. To determine the utility of a disposable colorimetric end-tidal CO2 detector during pediatric cardiopulmonary resuscitation (CPR) for (1) confirming endotracheal tube (ETT) position, and (2) assessing the relationship between end-tidal CO2 recorded by this method and outcome of pediatric CPR. Design/setting. Prospective observations during CPR in a university children's hospital. Participants. Forty children (28 male, 12 female) aged 1 week to 10 years (25 children aged ≤1 year, mean age 27.2 months, median 7 months), weighing 2.5 to 40 kg (31 children weighing ≤15 kg, mean 10.94 kg, median 7 kg) who underwent a total of 48 endotracheal intubations during CPR. Methods. After intubation, ETT position was verified by usual clinical methods including direct visualization. The device was attached between the ETT and ventilation bag, the patient was manually ventilated, and a first reading was obtained. Any color change from purple (Area A, end-tidal CO2 < 0.5%) to tan or yellow (Area B or C, end-tidal CO2 ≥ 0.5%) was considered to be positive for airway intubation. CPR was conducted as pen Pediatric Advanced Life Support guidelines. A second reading was obtained when the decision to discontinue CPR was made. Results. All nine esophageal tube positions were correctly identified by the detector. Thirty-three of 39 tracheal tube positions were correctly identified (P < .001). For verifying ETT position, the device had a sensitivity of 84.6%, specificity of 100%, positive predictive value of 100%, and negative predictive value of 60%. Readings were obtained at the end of CPR in 25 patients. All 13 patients who regained spontaneous circulation and survived to ICU admission had a second reading in the C range, while none of the 12 patients with a second reading in the A or B range survived. Both the first and second end-tidal CO2 readings in the C range correlated significantly with short-term survival (P = .01 and P < .001, respectively). Two patients were eventually discharged from the hospital. Conclusions. During CPR a positive test confirms placement of the ETT within the airway, whereas a negative test indicates either esophageal intubation or airway intubation with poor or absent pulmonary blood flow and requires an alternate means of confirmation of tube position. The detector may be of prognostic value for return of spontaneous circulation and short-term survival.

scholarly journals Evaluation of the survival rate of extra narrow dental implants (unitite slim 2.9 mm) full- arch implant supported

2020 ◽  
Vol 10 (1) ◽  
pp. 19-24
Author(s):  
Luana Cerqueira Viana ◽  
Lucas Santos Villar ◽  
Barbara Monique Moreira Conceição ◽  
Fabio Jose Barbosa Bezerra ◽  
Leonardos dos Santos Picinini ◽  
...  
Keyword(s):  
Survival Rate ◽  
Dental Implants ◽  
Alternative Therapy ◽  
Immediate Loading ◽  
Short Term ◽  
Term Survival ◽  
N Loading ◽  
Edentulous Patients ◽  
Implant System ◽  
Short Term Survival

The purpose was evaluating the short term survival rate of extra narrow diameter dental implants (2.9 mm, Unitite Slim, S.I.N. Implant System) used to support full-arch mandibular reconstructions. This was a randomized clinical trial analyzing the survival rate of 25 implants measuring 2.9 mm in diameter and 11.5 mm in length (Slim, Unitite, S.I.N. Implant System), and up to 40 N loading torque with immediate loading for protocol-type rehabilitation in the mandible region. Of the 25 implants, 100% remained in function after three months or 180 days of installation. Rehabilitation of total edentulous patients in the mandible with extra-narrow implants (2.9 mm) proved to be effective and promising as an alternative therapy to grafts.

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