Hypoxic preconditioning increases expression of HIF prolyl hydroxylase 2 (Egln1) in neonatal rat brain

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S312-S312
Author(s):  
Nicole M Jones ◽  
Philip M Beart
Keyword(s):  
Rat Brain ◽  
Prolyl Hydroxylase ◽  
Hypoxic Preconditioning ◽  
Neonatal Rat ◽  
Hif Prolyl Hydroxylase ◽  
Neonatal Rat Brain

scholarly journals Hypoxic Preconditioning Induces Changes in HIF-1 Target Genes in Neonatal Rat Brain

2001 ◽  
Vol 21 (9) ◽  
pp. 1105-1114 ◽  
Author(s):  
Nicole M. Jones ◽  
Marcelle Bergeron
Keyword(s):  
Gene Expression ◽  
Rat Brain ◽  
Target Genes ◽  
Hypoxia Inducible Factor ◽  
Hypoxic Preconditioning ◽  
Neonatal Rat ◽  
Glucose Transporter 1 ◽  
Glut 1 ◽  
Hypoxia Inducible Factor 1 ◽  
Neonatal Rat Brain

Hypoxic preconditioning induces tolerance to hypoxic-ischemic injury in neonatal rat brain and is associated with changes in gene expression. Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that is strongly induced by hypoxia or the hypoxia-mimetic compound cobalt chloride (CoCl2). Hypoxia-inducible factor-1 modulates the expression of several target genes including the glycolytic enzymes, glucose transporter-1 (GLUT-1), and erythropoietin. Recently, HIF-1 expression was shown to increase after hypoxic and CoCl2 preconditioning in newborn rat brain. To study the involvement of HIF-1 target genes in neonatal hypoxia-induced ischemic tolerance, the authors examined the brains of newborn rats after exposure to hypoxia (8% O2 for 3 hours) or injection of CoCl2 (60 mg/kg). Preconditioning with hypoxia or CoCl2 24 hours before hypoxia-ischemia afforded a 96% and 76% brain protection, respectively, compared with littermate control animals. Hypoxic preconditioning increased the expression of GLUT-1 mRNA and protein, and of aldolase, phosphofructokinase, and lactate dehydrogenase proteins but not mRNA. This suggests that the modulation of glucose transport and glycolysis by hypoxia may contribute to the development of hypoxia-induced tolerance. In contrast, preconditioning with CoCl2 did not produce any change in HIF-1 target gene expression suggesting that different molecular mechanisms may be involved in the induction of tolerance by hypoxia and CoCl2 in newborn brain.

In vivo diffusion tensor imaging of the neonatal rat brain development

2013 ◽  
Vol 44 (S 01) ◽  
Author(s):  
M Breu ◽  
D Reisinger ◽  
D Wu ◽  
Y Zhang ◽  
A Fatemi ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Brain Development ◽  
Rat Brain ◽  
Diffusion Tensor ◽  
Neonatal Rat ◽  
Neonatal Rat Brain

Resveratrol ameliorates hypoxia/ischemia-induced behavioral deficits and brain injury in the neonatal rat brain

2011 ◽  
Vol 1425 ◽  
pp. 98-110 ◽  
Author(s):  
Filippos Karalis ◽  
Vassiliki Soubasi ◽  
Thomas Georgiou ◽  
Christos T. Nakas ◽  
Constantina Simeonidou ◽  
...  
Keyword(s):  
Brain Injury ◽  
Rat Brain ◽  
Neonatal Rat ◽  
Behavioral Deficits ◽  
Hypoxia Ischemia ◽  
Neonatal Rat Brain

Neuroprotection against hypoxia-ischemia in neonatal rat brain by novel superoxide dismutase mimetics

2003 ◽  
Vol 346 (1-2) ◽  
pp. 41-44 ◽  
Author(s):  
Katsuyoshi Shimizu ◽  
Nishadi Rajapakse ◽  
Takashi Horiguchi ◽  
R.Mark Payne ◽  
David W. Busija
Keyword(s):  
Superoxide Dismutase ◽  
Rat Brain ◽  
Neonatal Rat ◽  
Hypoxia Ischemia ◽  
Superoxide Dismutase Mimetics ◽  
Neonatal Rat Brain
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