Identification and characterization of a novel human brain-specific gene, homologous to S. scrofa tmp83.5 , in the chromosome 10q24 critical region for temporal lobe epilepsy and spastic paraplegia

Gene ◽  
2002 ◽  
Vol 282 (1-2) ◽  
pp. 87-94 ◽  
Author(s):  
C Nobile ◽  
B Hinzmann ◽  
P Scannapieco ◽  
R Siebert ◽  
R Zimbello ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Human Brain ◽  
Temporal Lobe ◽  
Critical Region ◽  
Specific Gene ◽  
Spastic Paraplegia ◽  
Identification And Characterization

Characterization of neurons in the cortical white matter in human temporal lobe epilepsy

Neuroscience ◽  
2016 ◽  
Vol 333 ◽  
pp. 140-150 ◽  
Author(s):  
Zsófia Richter ◽  
József Janszky ◽  
György Sétáló ◽  
Réka Horváth ◽  
Zsolt Horváth ◽  
...  
Keyword(s):  
White Matter ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Human Temporal Lobe

scholarly journals Identification and characterization of cis-regulatory elements for photoreceptor type-specific transcription in zebrafish

2019 ◽  
Author(s):  
Wei Fang ◽  
Yi Wen ◽  
Xiangyun Wei
Keyword(s):  
Core Promoter ◽  
Regulatory Elements ◽  
Specific Gene ◽  
Protein Coding ◽  
Core Promoters ◽  
Protein Coding Genes ◽  
The Core ◽  
Cell Type Specific ◽  
Identification And Characterization

AbstractTissue-specific or cell type-specific transcription of protein-coding genes is controlled by both trans-regulatory elements (TREs) and cis-regulatory elements (CREs). However, it is challenging to identify TREs and CREs, which are unknown for most genes. Here, we describe a protocol for identifying two types of transcription-activating CREs—core promoters and enhancers—of zebrafish photoreceptor type-specific genes. This protocol is composed of three phases: bioinformatic prediction, experimental validation, and characterization of the CREs. To better illustrate the principles and logic of this protocol, we exemplify it with the discovery of the core promoter and enhancer of the mpp5b apical polarity gene (also known as ponli), whose red, green, and blue (RGB) cone-specific transcription requires its enhancer, a member of the rainbow enhancer family. While exemplified with an RGB cone-specific gene, this protocol is general and can be used to identify the core promoters and enhancers of other protein-coding genes.

scholarly journals Identification and Characterization of a Critical Region in the Glycogen Synthase fromEscherichia coli

2003 ◽  
Vol 279 (9) ◽  
pp. 8359-8367 ◽  
Author(s):  
Alejandra Yep ◽  
Miguel A. Ballicora ◽  
Mirta N. Sivak ◽  
Jack Preiss
Keyword(s):  
Critical Region ◽  
Glycogen Synthase ◽  
Fromescherichia Coli ◽  
Identification And Characterization

scholarly journals MEDU-31. IDENTIFICATION AND CHARACTERIZATION OF A NOVEL PATIENT-SPECIFIC GENE COMBINATION TO MODEL GROUP3 MEDULLOBLASTOMA

2019 ◽  
Vol 21 (Supplement_2) ◽  
pp. ii109-ii109
Author(s):  
Claudio Ballabio ◽  
Marica Anderle ◽  
Matteo Gianesello ◽  
Giuseppe Aiello ◽  
Luca Tiberi
Keyword(s):  
Patient Specific ◽  
Specific Gene ◽  
Gene Combination ◽  
Identification And Characterization

Identification and Characterization of a SET/NAP Protein Encoded by a Brain-Specific Gene, MB20

Genomics ◽  
2001 ◽  
Vol 71 (1) ◽  
pp. 21-33 ◽  
Author(s):  
Hsin-Hsin Shen ◽  
A-Mei Huang ◽  
Jörg Hoheisel ◽  
Shih-Feng Tsai
Keyword(s):  
Specific Gene ◽  
Identification And Characterization

Sexual ictal manifestations predominate in women with temporal lobe epilepsy: A finding suggesting sexual dimorphism in the human brain

Neurology ◽  
1983 ◽  
Vol 33 (3) ◽  
pp. 323-323 ◽  
Author(s):  
G. M. Remillard ◽  
F. Andermann ◽  
G. F. Testa ◽  
P. Gloor ◽  
M. Aube ◽  
...  
Keyword(s):  
Sexual Dimorphism ◽  
Temporal Lobe Epilepsy ◽  
Human Brain ◽  
Temporal Lobe

An historical and genomic view of schistosome conjugal biology with emphasis on sex-specific gene expression

Parasitology ◽  
2004 ◽  
Vol 128 (S1) ◽  
pp. S11-S22 ◽  
Author(s):  
K. F. HOFFMANN
Keyword(s):  
Dna Microarrays ◽  
Historical Review ◽  
Transcriptional Gene Silencing ◽  
Specific Gene ◽  
Post Transcriptional Gene Silencing ◽  
Genomic Tools ◽  
Tools And Techniques ◽  
Sexually Mature ◽  
Identification And Characterization

The genetic programmes associated with the sexual biology of dioecious schistosomes remain a critically important but significantly understudied area of parasitology. Throughout the last four decades, progress has been slow in describing the gross antigenic and proteomic differences linked to sexually mature schistosomes and in characterizing some of the sex-associated transcripts and regulatory mechanisms induced during developmental maturation. These investigations have been severely hindered by the lack of complete EST/genomic information, as well as corresponding post- and functional-genomic tools for studying these pathogenic parasites. As near complete transcriptomes forSchistosoma japonicumandS. mansonihave recently been reported, and both DNA microarrays and post-transcriptional gene silencing have been applied to schistosomes, the tools and techniques for the high-throughput identification and characterization of transcripts involved in conjugal biology are now readily available. Here, an historical review is presented that summarizes some of the most significant findings associated with schistosome sex and sexual maturation during the last several decades. Following this discussion is a current overview of some modern day genomic approaches used to study schistosomes, which illustrates how major advances in the field of conjugal biology will be achieved.

scholarly journals Selectivity of pyramidal cells and interneurons in the human medial temporal lobe

2011 ◽  
Vol 106 (4) ◽  
pp. 1713-1721 ◽  
Author(s):  
Matias J. Ison ◽  
Florian Mormann ◽  
Moran Cerf ◽  
Christof Koch ◽  
Itzhak Fried ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Visual Information ◽  
Medial Temporal Lobe ◽  
Pyramidal Cells ◽  
Hierarchical Processing ◽  
Plausible Mechanism ◽  
Underlying Mechanisms ◽  
Identification And Characterization

Neurons in the medial temporal lobe (MTL) respond selectively to pictures of specific individuals, objects, and places. However, the underlying mechanisms leading to such degree of stimulus selectivity are largely unknown. A necessary step to move forward in this direction involves the identification and characterization of the different neuron types present in MTL circuitry. We show that putative principal cells recorded in vivo from the human MTL are more selective than putative interneurons. Furthermore, we report that putative hippocampal pyramidal cells exhibit the highest degree of selectivity within the MTL, reflecting the hierarchical processing of visual information. We interpret these differences in selectivity as a plausible mechanism for generating sparse responses.

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