INFLUENCE OF METABOLIC SYNDROME ON BONE MINERAL DENSITY IN MENOPAUSAL WOMEN (PRELIMINARY STUDY)

Background ― Metabolic syndrome (MetS) is the world's major public health problem. Objectives ― Assessment of metabolic syndrome impact on bone mineral density (BMD) among Saudi menopausal women in Eastern Province – Saudi Arabia. Material and Methods ― It’s a case control study and 380 menopausal Saudi women were selected through stratified random sampling; they are divided into 190 cases with osteoporosis and 190 without osteoporosis. BMD at the total hip were determined using dual-energy X-ray absorptiometry (DEXA). The T score was calculated, the relationship between the risk factors of MetS and bone mineral density were analyzed by statistical methods. Results ― Prevalence of MetS was substantially higher among osteoprotic women. The MetS is significantly correlated with bone mineral density (r=0.08, P=0.05). The occurrence of MetS was associated with increased osteoporosis among Saudi women (B=0.004; 0.05) after adjustment of confounders. The presence of obesity (component of MetS) was significantly associated with increased odds of Bone marrow density among women (OR 2.56, 95% CI, 2.22–3.44, P=0.030) after adjustment of confounders. Conclusion ― MetS was significantly associated with an osteoporosis in Saudi women.

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Association between vitamin D and bone mineral density in post-menopausal women with metabolic syndrome

Acta medica Lituanica ◽

10.6001/actamedica.v22i1.3074 ◽

2015 ◽

Vol 22 (1) ◽

pp. 7-14

Author(s):

Jolanta Dadonienė ◽

Alma Čypienė ◽

Egidija Rinkūnienė ◽

Jolita Badarienė ◽

Jelizaveta Burca ◽

...

Keyword(s):

Bone Mineral Density ◽

Metabolic Syndrome ◽

Vitamin D ◽

Bone Mineral ◽

Density Lipoprotein ◽

Serum Glucose ◽

Mineral Density ◽

Normal Bone Mineral Density ◽

Menopausal Women ◽

Post Menopausal

Background. The aim of this study was to identify the relation between vitamin D level and mineral bone density in post-menopausal women with metabolic syndrome. Materials and methods. This study included 100 post-menopausal women at age between 50 and 65 with metabolic syndrome. All participants underwent anthropometric measurements. Laboratory tests were performed to determine lipid profile, serum glucose, creatinine, C-reactive protein, vitamin D (25(OH) D), ionized calcium concentration and urine albumin / creatinine ratio. Bone mineral density of the lumbar spine (L1– L4) and total hip was measured by dual-energy X-ray absorptiometry. Results. According to the vitamin D concentration level in the blood all women were divided into four groups: the average failure was observed in 57%, mild failure in 33%, severe failure in 5%; and only 5% of women had normal vitamin levels. The mean 25(OH) D level was 47.40 ± 16.91 nmol/l. According to bone densitometry we found that 77% of all participants had normal bone mineral density, 22% had osteopenia and 5% were diagnosed with osteoporosis. No correlation was found between bone mineral density and 25(OH) D levels. We found a weak positive correlation between high density lipoprotein cholesterol and 25(OH) D (r = 0.3, p

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