FRI-016-Validation of the PREsTo machine learning algorithm for the prediction of disease progression in patients with primary sclerosing cholangitis

2019 ◽  
Vol 70 (1) ◽  
pp. e390-e391 ◽  
Author(s):  
John Eaton ◽  
Konstantinos Lazaridis ◽  
Pietro Invernizzi ◽  
Olivier Chazouillères ◽  
Gideon Hirschfield ◽  
...  
2021 ◽  
Author(s):  
Howard Maile ◽  
Ji-Peng Olivia Li ◽  
Daniel Gore ◽  
Marcello Leucci ◽  
Padraig Mulholland ◽  
...  

BACKGROUND Keratoconus is a disorder characterized by progressive thinning and distortion of the cornea. If detected at an early stage corneal collagen cross linking can prevent disease progression and further visual loss. Whilst advanced forms are easily detected, reliably identifying subclinical disease can be problematic. A number of different machine learning algorithms have been used to improve the detection of subclinical keratoconus based on the analysis of single or multiple clinical measures such as corneal imaging, aberrometry, or biomechanical measurements. OBJECTIVE To survey and critically evaluate the literature on algorithmic detection of subclinical keratoconus and equivalent definitions. METHODS We performed a structured search of the following databases: Medical Literature Analysis and Retrieval System Online (MEDLINE), Excerpta Medica Database (EMBASE), Web of Science and Cochrane from Jan 1, 2010 to Oct 31, 2020. We included all full text studies that have used algorithms for the detection of subclinical keratoconus. We excluded studies that did not perform validation. RESULTS We compared the parameters measured and the design of the machine learning algorithms reported in 26 papers that met the inclusion criteria. All salient information required for detailed comparison including diagnostic criteria, demographic data, sample size, acquisition system, validation details, parameter inputs, machine learning algorithm and key results are reported in this study. CONCLUSIONS Machine learning has the potential to improve the detection of subclinical keratoconus or early keratoconus in routine ophthalmic practice. Presently there is no consensus regarding the corneal parameters that should be included for assessment and the optimal design for the machine learning algorithm. We have identified avenues for further research to improve early detection and stratification of patients for early intervention to prevent disease progression. CLINICALTRIAL N/A


2018 ◽  
Author(s):  
C.H.B. van Niftrik ◽  
F. van der Wouden ◽  
V. Staartjes ◽  
J. Fierstra ◽  
M. Stienen ◽  
...  

Author(s):  
Kunal Parikh ◽  
Tanvi Makadia ◽  
Harshil Patel

Dengue is unquestionably one of the biggest health concerns in India and for many other developing countries. Unfortunately, many people have lost their lives because of it. Every year, approximately 390 million dengue infections occur around the world among which 500,000 people are seriously infected and 25,000 people have died annually. Many factors could cause dengue such as temperature, humidity, precipitation, inadequate public health, and many others. In this paper, we are proposing a method to perform predictive analytics on dengue’s dataset using KNN: a machine-learning algorithm. This analysis would help in the prediction of future cases and we could save the lives of many.


2019 ◽  
Vol XVI (4) ◽  
pp. 95-113
Author(s):  
Muhammad Tariq ◽  
Tahir Mehmood

Accurate detection, classification and mitigation of power quality (PQ) distortive events are of utmost importance for electrical utilities and corporations. An integrated mechanism is proposed in this paper for the identification of PQ distortive events. The proposed features are extracted from the waveforms of the distortive events using modified form of Stockwell’s transform. The categories of the distortive events were determined based on these feature values by applying extreme learning machine as an intelligent classifier. The proposed methodology was tested under the influence of both the noisy and noiseless environments on a database of seven thousand five hundred simulated waveforms of distortive events which classify fifteen types of PQ events such as impulses, interruptions, sags and swells, notches, oscillatory transients, harmonics, and flickering as single stage events with their possible integrations. The results of the analysis indicated satisfactory performance of the proposed method in terms of accuracy in classifying the events in addition to its reduced sensitivity under various noisy environments.


Sign in / Sign up

Export Citation Format

Share Document