scholarly journals MEASURING CORONARY ARTERY CALCIFICATION IN COMBINATION WITH HIGH-SENSITIVE C-REACTIVE PROTEIN PREDICTS HARD CORONARY EVENTS BEYOND FRAMINGHAM RISK SCORE CATEGORIES - DATA FROM THE HEINZ NIXDORF RECALL STUDY

2010 ◽  
Vol 55 (10) ◽  
pp. A70.E656
Author(s):  
Stefan Mö;hlenkamp ◽  
Nils Lehmann ◽  
Susanne Moebus ◽  
Axel Schmermund ◽  
Nico Dragano ◽  
...  
2017 ◽  
Vol 15 (4) ◽  
pp. 539-546
Author(s):  
Elizabeth Do Canto Brancher ◽  
Dannuey Machado Cardoso ◽  
Tiago José Nardi Gomes ◽  
Tamires Daros dos Santos ◽  
Marília Severo Vicente ◽  
...  

Introduction: Coronary artery bypass grafting (CABG) does not have an effect on the etiopathogenic factors of atherosclerosis, thus, it is crucial to control risk factors. Objective: To analyze the effect of a cardiac rehabilitation (CR) program on cardiovascular risk factors, the Framingham risk score (FRS) and levels of C-reactive protein (CRP) of patients undergoing CABG. Methods: A descriptive, cross-sectional and retrospective study was conducted with a sample of 49 patients, who were participating in a program (24 weeks). Body mass index (BMI), waist circumference (WC), FRS, risk (%) of developing coronary artery disease in 10 years (CAD risk), serum levels of LDL-c, triglycerides (TG) and CRP were assessed. Results: The variables BMI, WC, LDL-c, TG, CRP levels, FRS and CAD risk showed significant reductions (p


2014 ◽  
Vol 78 (2) ◽  
pp. 119-123 ◽  
Author(s):  
Elif Didem Ozdemir ◽  
Gamze Sinem Caglar ◽  
Ebru Akgul ◽  
Sevim Dincer Cengiz ◽  
Gamze Tombak

2021 ◽  
pp. 1-8
Author(s):  
Neil Roy ◽  
Sylvia E. Rosas

<b><i>Introduction:</i></b> Inflammation is important in the pathogenesis of atherosclerosis. Elevated interleukin-6 (IL-6) is associated with cardiovascular events and also predicts mortality in individuals with CKD. Our goal was to determine the association between IL-6, FGF23, and high-sensitivity C-reactive protein (hsCRP) on coronary artery calcification (CAC) progression and mortality in incident dialysis patients without prior coronary events. <b><i>Methods:</i></b> A prospective cohort of incident adult dialysis participants had CAC measured by ECG-triggered multislice CT scans at baseline and at least 12 months later. Lipids, mineral metabolism markers, FGF23, and inflammatory markers, such as IL-6 and hsCRP, were measured at the baseline visit. <b><i>Results:</i></b> Participants in the high IL-6 tertile had the highest baseline CAC score (133.25 [10.35–466.15]) compared to the low (0.25 [0–212.2]) and intermediate (29.55 [0–182.85]) tertiles. Almost half of the participants with high IL-6 (15 of 32 [46.9%]) experienced progression of CAC compared to participants with low (8 of 32 [25%]) and intermediate (9 of 32 [28.1%]) (<i>p</i> = 0.05) IL-6 levels. Each log increase in IL-6 was associated with increase in death (hazard ratio 2.2, 95% CI: 1.2–3.8; <i>p</i> = 0.01). After adjusting for smoking, age, gender, race, diabetes, phosphate, and baseline calcium score, IL-6 (log) was associated with 2.2 times (95% CI: 1.1–4.6; <i>p</i> = 0.03) increase in death. <b><i>Conclusion:</i></b> IL-6 is associated with progression of CAC and mortality in incident dialysis patients.


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