scholarly journals INCREMENTAL BENEFIT OF CORONARY ARTERY CALCIUM SCORE OVER TRADITIONAL RISK FACTORS FOR ALL-CAUSE MORTALITY IN ASIAN POPULATION FROM KOICA REGISTRY (KOREA INITIATIVES ON CORONARY ARTERY CALCIFICATION: MULTICENTER REGISTRY)

2015 ◽  
Vol 65 (10) ◽  
pp. A1065
Author(s):  
Dong Hee Han ◽  
Ji Hyun Yoon ◽  
Kwang Joon Kim ◽  
Min-kyoung Kim ◽  
Su Yeon Choi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery ◽  
Coronary Artery Calcium ◽  
Coronary Artery Calcification ◽  
Coronary Artery Calcium Score ◽  
Calcium Score ◽  
Asian Population ◽  
All Cause Mortality ◽  
Traditional Risk Factors ◽  
Multicenter Registry

scholarly journals Atherogenic index of plasma and coronary artery calcification progression beyond traditional risk factors according to baseline coronary artery calcium score

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ki-Bum Won ◽  
Donghee Han ◽  
Ji Hyun Lee ◽  
Su-Yeon Choi ◽  
Eun Ju Chun ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery ◽  
Coronary Artery Calcium ◽  
Coronary Artery Calcification ◽  
Coronary Artery Calcium Score ◽  
Calcium Score ◽  
Atherogenic Index ◽  
Atherogenic Index Of Plasma ◽  
Traditional Risk Factors

AbstractThis study aimed to evaluate the association between the atherogenic index of plasma (AIP), which has been suggested as a novel marker for atherosclerosis, and coronary artery calcification (CAC) progression according to the baseline coronary artery calcium score (CACS). We included 12,326 asymptomatic Korean adults who underwent at least two CAC evaluations from December 2012 to August 2016. Participants were stratified into four groups according to AIP quartiles, which were determined by the log of (triglyceride/high-density lipoprotein cholesterol). Baseline CACSs were divided into three groups: 0, 1 − 100, and > 100. CAC progression was defined as a difference ≥ 2.5 between the square roots (√) of the baseline and follow-up CACSs (Δ√transformed CACS). Annualized Δ√transformed CACS was defined as Δ√transformed CACS divided by the inter-scan period. During a mean 3.3-year follow-up period, the overall incidence of CAC progression was 30.6%. The incidences of CAC progression and annualized Δ√transformed CACS were markedly elevated with increasing AIP quartile in participants with baseline CACSs of 0 and 1 − 100, but not in those with a baseline CACS > 100. The AIP level was associated with the annualized Δ√transformed CACS in participants with baseline CACSs of 0 (β = 0.016; P < 0.001) and 1 − 100 (β = 0.035; P < 0.001), but not in those with baseline CACS > 100 (β = 0.032; P = 0.385). After adjusting for traditional risk factors, the AIP was significantly associated with CAC progression in those with baseline CACS ≤ 100. The AIP has value for predicting CAC progression in asymptomatic adults without heavy baseline CAC.

scholarly journals Gender Differences in the Atherosclerosis Profile by Coronary CTA in Coronary Artery Calcium Score Zero Patients

2021 ◽  
Vol 10 (6) ◽  
pp. 1220
Author(s):  
Thomas Senoner ◽  
Fabian Plank ◽  
Christoph Beyer ◽  
Christian Langer ◽  
Katharina Birkl ◽  
...  
Keyword(s):  
Gender Differences ◽  
Coronary Artery ◽  
Cardiovascular Mortality ◽  
Coronary Artery Calcium ◽  
Coronary Artery Calcium Score ◽  
Calcium Score ◽  
Plaque Burden ◽  
Term Outcome ◽  
Long Term Outcome ◽  
All Cause Mortality

Background: The coronary artery calcium score (CACS) is a powerful tool for cardiovascular risk stratification. Coronary computed tomography angiography (CTA) allows for a more distinct analysis of atherosclerosis. The aim of the study was to assess gender differences in the atherosclerosis profile of CTA in patients with a CACS of zero. Methods: A total of 1451 low- to intermediate-risk patients (53 ± 11 years; 51% females) with CACS <1.0 Agatston units (AU) who underwent CTA and CACS were included. Males and females were 1:1 propensity score-matched. CTA was evaluated for stenosis severity (Coronary Artery Disease – Reporting and Data System (CAD-RADS) 0–5: minimal <25%, mild 25–49%, moderate 50–69%, severe ≥70%), mixed-plaque burden (G-score), and high-risk plaque (HRP) criteria (low-attenuation plaque, spotty calcification, napkin-ring sign, and positive remodeling). All-cause mortality, cardiovascular mortality, and major cardiovascular events (MACEs) were collected. Results: Among the patients, 88.8% had a CACS of 0 and 11.2% had an ultralow CACS of 0.1–0.9 AU. More males than females (32.1% vs. 20.3%; p < 0.001) with a CACS of 0 had atherosclerosis, while, among those with an ultralow CACS, there was no difference (88% vs. 87.1%). Nonobstructive CAD (25.9% vs. 16.2%; p < 0.001), total plaque burden (2.2 vs. 1.4; p < 0.001), and HRP were found more often in males (p < 0.001). After a follow-up of mean 6.6 ± 4.2 years, all-cause mortality was higher in females (3.5% vs. 1.8%, p = 0.023). Cardiovascular mortality and MACEs were low (0.2% vs. 0%; p = 0.947 and 0.3% vs. 0.6%; p = 0.790) for males vs. females, respectively. Females were more often symptomatic for chest pain (70% vs. 61.6%; p = 0.004). (4) Conclusions: In patients with a CACS of 0, males had a higher prevalence of atherosclerosis, a higher noncalcified plaque burden, and more HRP criteria. Nonetheless, females had a worse long–term outcome and were more frequently symptomatic.

Abstract 18550: Association Between a Healthy Cardiovascular Risk Factors Profile and Coronary Artery Calcium Score: Results From the Brazilian Longitudinal Study of Adults Health (ELSA-Brasil)

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Isabela M Bensenor ◽  
Alessandra C Goulart ◽  
Itamar S Santos ◽  
Dora Chor ◽  
Alexandre C Pereira ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Longitudinal Study ◽  
Coronary Artery ◽  
Cardiovascular Risk Factors ◽  
Coronary Artery Calcium ◽  
Task Force ◽  
Coronary Artery Calcium Score ◽  
Subclinical Atherosclerosis ◽  
Calcium Score

Introduction: Few studies evaluated the relationship between a favorable lifestyle a healthy profile of cardiovascular risk factors and subclinical atherosclerosis measured by Coronary Artery Calcium Score (CAC). Hypothesis: to identify the association between lifestyle profile and CAC among mid-elderly men and women. Methods: We included 4058 participants of the Brazilian Longitudinal Study of Health aged 35-74 years who underwent CAC measurement. The 2010 Task Force of the American Heart Association cut-offs were used to define the ideal profile and included smoking, physical activity, diet, blood pressure, glucose/cholesterol levels, and body-mass index. Only 21 participants had at least 6 ideal metrics. Participants were categorized according the number of ideal risk factors (IRF): 0-1 (n=1152, 28.4%), 2 (n=1234, 30.4%), 3-4 (n=1489, 36.7%), or 5-7 (n=183, 4.5%). (Figure 1). Results: Compared to individuals with 0-1 IRF, the odds ratio (OR) of participants with 2 IRF presenting with CAC of 0 (compared to >0), <100 (compared to ≥100), and <400 (compared to ≥400) was 0.65 (95% confidence interval [CI]: 0.54-0.79), 0.59 (95%CI: 0.45-0.77), and 0.61 (95%CI: 0.39-0.94), respectively. Similarly, the ORs of CACs of 0, <100, and <400 in individuals with 3-4 IRF were 0.54 (95%CI: 0.44-0.66), 0.42 (95%CI: 0.31-0.57), and 0.56 (95%CI: 0.34-0.92), respectively. The ORs of CACs of 0, <100, and <400 in individuals with 5-7 IRF were 0.33 (95%CI: 018-0.58), 0.17 (95%CI: 0.04-0.72), and zero, respectively. Conclusion: Subjects with more IRF had lower CAC compared to subjects with lower ICH metrics, but CAC >0 was found even in these individuals.

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