PREDICTORS OF SHORT- AND LONG-TERM MORTALITY IN ACUTE CORONARY SYNDROME PRESENTING AS OUT-OF-HOSPITAL CARDIAC ARREST

Objectives: To evaluate clinical characteristics and prognosis of patients presented with ventricular tachyarrhythmia (VTA) during the course of acute coronary syndrome (ACS) and to analyze it according to period of presentation. Background: VTA is an infrequent yet serious complication of ACS. There is limited data regarding the incidence and prognostic implications of VTA in the last decade as compared with the previous decade. Methods: We evaluated clinical characteristics, major adverse cardiovascular events, short and long- term mortality of patients hospitalized with ACS who were enrolled in the Acute Coronary Syndrome Israeli Survey (ACSIS) during the years 2000-2016. Patients were classified into three groups: no VTA, early VTA (≤48h of onset) and late VTA (>48h of onset). Data were analyzed according to decades of presentation (current decade vs. previous decade). Results: The study population comprised 15,200 patients. VTA occurred in 487 (3.2%) of patients. Early VTA presented in 373/487 (77%) patients and late VTA in 114/487 (23%) patients. VTA’s, occurring in ACS patients were associated with increased risk of in-hospital, 30-days, 1-year and 5-year mortality rates during both early and late periods in compared with no VTA. Moreover, late VTA was associated with the highest mortality rate with up to 65% in 5-year follow up (p<0.001). Nevertheless, late VTA was associated with lower mortality rate in the current decade (2008-2016) compared with last decade (2000-2006). Conclusions: Any VTA following ACS was associated with high short and long-term mortality rate. However, over the past decade there has been a significant improvement in survival rates, especially in patients with late VTA. This may be attributed to early and invasive reperfusion therapy, implantable cardioverter defibrillator implantation and better medical treatment.

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Prognostic value of carotid intima-media in the short- and long-term mortality in the Strategy of Registry of Acute Coronary Syndrome (ERICO) study

Echocardiography ◽

10.1111/echo.14044 ◽

2018 ◽

Vol 35 (9) ◽

pp. 1351-1361

Author(s):

Danilo P. Meireles ◽

Itamar S. Santos ◽

Airlane P. Alencar ◽

Paulo A. Lotufo ◽

Isabela M. Benseñor ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

Prognostic Value ◽

Coronary Syndrome ◽

Short And Long Term ◽

Long Term Mortality

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Impact of evidence-based cardiac medications on short and long-term mortality in 7,567 acute coronary syndrome patients in the Gulf RACE-II registry

International Journal of Clinical Pharmacology and Therapeutics ◽

10.5414/cp201667 ◽

2012 ◽

Vol 50 (06) ◽

pp. 418-425 ◽

Cited By ~ 5

Author(s):

Ibrahim Al-Zakwani ◽

Kadhim Sulaiman ◽

Mohammed Al Za’abi ◽

Prashanth Panduranga ◽

Khalid Al-Habib ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

Evidence Based ◽

Coronary Syndrome ◽

Short And Long Term ◽

Long Term Mortality

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Killip-Kimball Classification Validation, Outcomes and Demographics in an Octogenarian Cohort with Acute Coronary Syndrome in a Developing Country: A Third-Level Multicenter 11-Year Experience

10.1101/2020.09.14.20194480 ◽

2020 ◽

Author(s):

Diego Ramonfaur ◽

David E Hinojosa-Gonzalez ◽

Jose G Paredes-Vazquez

Keyword(s):

Acute Coronary Syndrome ◽

Hospital Mortality ◽

Kidney Injury ◽

The Elderly ◽

Killip Class ◽

Coronary Syndrome ◽

Short And Long Term ◽

Catheterization Procedure ◽

Long Term Mortality

Introduction: The Killip-Kimball Classification (KC) is used to group patients with acute coronary syndrome (ACS) based on their clinical profile. It has proven to be useful while predicting both short- and long-term mortality. Contemporary data in the elderly population is limited. We sought to analyze trends in outcomes of patients 80 years or older admitted for ACS, by Killip Class. In addition, we assess the validity of the KC in this population. Methodology: A retrospective analysis of patients who underwent a catheterization procedure for ACS was performed. ACS was defined as per AHA guidelines, and included STEMI, non-STEMI and Unstable Angina. We determined factors influencing the KC in which patients present to the emergency room. Likewise, we compared in-hospital mortality, length of stay, and other outcomes dividing the patients by KC. Results: A total of 133 patients were analyzed. Included were: 86, 9, 23 and 15 patients in KC-I through IV respectively with a mean age of 83. The main comorbidities were hypertension (73%), and diabetes (43%). In-hospital mortality was 12%, which was different between KC groups (p< 0.01). In addition, we found higher KC groups to be associated with acute kidney injury during the hospitalization (p< 0.01). Conclusion: Despite a strong reduction in mortality for elderly patients with ACS in recent decades, patients presenting with ACS and higher Killip class have a high mortality rate, as described in younger cohorts. The Killip-Kimball classification remains a reliable prognostic tool, with applicability in octogenarian patients.

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C-reactive protein provides independent prognostic information on short- and long-term mortality in patients with non-st elevation acute coronary syndrome: Reply

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(03)00891-x ◽

2003 ◽

Vol 42 (6) ◽

pp. 1145-1146 ◽

Cited By ~ 1

Author(s):

Stefan James ◽

Lars Wallentin

Keyword(s):

Acute Coronary Syndrome ◽

C Reactive Protein ◽

Prognostic Information ◽

Reactive Protein ◽

Coronary Syndrome ◽

Short And Long Term ◽

St Elevation ◽

Elevation Acute Coronary Syndrome ◽

Long Term Mortality

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Temporal Trends in Prognosis of Patients with Acute Coronary Syndrome Complicated by Ventricular Tachyarrhythmia

Clinical Cardiology and Cardiovascular Interventions ◽

10.31579/2641-0419/118 ◽

2021 ◽

Vol 4 (3) ◽

pp. 01-07

Author(s):

Ella Yahud

Keyword(s):

Acute Coronary Syndrome ◽

Mortality Rate ◽

Clinical Characteristics ◽

Ventricular Tachyarrhythmia ◽

Coronary Syndrome ◽

Increased Risk ◽

Previous Decade ◽

Short And Long Term ◽

Long Term Mortality

Objectives: To evaluate clinical characteristics and prognosis of patients presented with ventricular tachyarrhythmia (VTA) during the course of acute coronary syndrome (ACS) and to analyze it according to period of presentation. Background: VTA is an infrequent yet serious complication of ACS. There is limited data regarding the incidence and prognostic implications of VTA in the last decade as compared with the previous decade. Methods: We evaluated clinical characteristics, major adverse cardiovascular events, short and long- term mortality of patients hospitalized with ACS who were enrolled in the Acute Coronary Syndrome Israeli Survey (ACSIS) during the years 2000-2016. Patients were classified into three groups: no VTA, early VTA (≤48h of onset) and late VTA (>48h of onset). Data were analyzed according to decades of presentation (current decade vs. previous decade). Results: The study population comprised 15,200 patients. VTA occurred in 487 (3.2%) of patients. Early VTA presented in 373/487 (77%) patients and late VTA in 114/487 (23%) patients. VTA’s, occurring in ACS patients were associated with increased risk of in-hospital, 30-days, 1-year and 5-year mortality rates during both early and late periods in compared with no VTA. Moreover, late VTA was associated with the highest mortality rate with up to 65% in 5-year follow up (p<0.001). Nevertheless, late VTA was associated with lower mortality rate in the current decade (2008-2016) compared with last decade (2000-2006). Conclusions: Any VTA following ACS was associated with high short and long-term mortality rate. Howevr, over the past decade there has been a significant improvement in survival rates, especially in patients with late VTA. This may be attributed to early and invasive reperfusion therapy, implantable cardioverter defibrillator implantation and better medical treatment.

Download Full-text