Developmentally induced microencephalopathy in guinea pigs ‐embryonic glial cell activation marks selective neuronal death

2001 ◽  
Vol 19 (3) ◽  
pp. 313-318 ◽  
Author(s):  
Steffen Roßner ◽  
Martina K. Brückner ◽  
Volker Bigl
Keyword(s):  
Glial Cell ◽  
Neuronal Death ◽  
Guinea Pigs ◽  
Cell Activation ◽  
Glial Cell Activation ◽  
Selective Neuronal Death

scholarly journals SARS-CoV-2 Spike Protein Induces Cognitive Deficit and Anxiety-like Behavior in Mouse via Non-cell Autonomous Hippocampal Neuronal Death

2022 ◽  
Author(s):  
Sung Joong Lee ◽  
Jun Young Oh ◽  
Woo-Hyun Cho ◽  
Barcelon Ellane ◽  
Kwang Hwan Kim ◽  
...  
Keyword(s):  
Cell Death ◽  
Glial Cell ◽  
Neuronal Death ◽  
Cell Activation ◽  
Cognitive Deficit ◽  
Neuronal Cell ◽  
Neurological Symptoms ◽  
Spike Protein ◽  
Glial Cell Activation ◽  
The Brain

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is accompanied by chronic neurological sequelae such as cognitive decline and mood disorder, but the underlying mechanisms have not yet been elucidated. In this study, we explored the possibility that the brain-infiltrating SARS-CoV-2 spike protein contributes to the development of neurological symptoms observed in COVID-19 patients. Our behavioral study showed that administration of SARS-CoV-2 spike protein S1 subunit (S1 protein) to mouse hippocampus induced cognitive deficit and anxiety-like behavior in vivo. These neurological symptoms were accompanied by neuronal cell death in the dorsal and ventral hippocampus as well as glial cell activation. Interestingly, the S1 protein did not directly induce hippocampal cell death in vitro. Rather, it exerted neurotoxicity via glial cell activation, partially through interleukin-1β induction. In conclusion, our data suggest a novel pathogenic mechanism for the COVID-19-associated neurological symptoms that involves glia activation and non-cell autonomous hippocampal neuronal death by the brain-infiltrating S1 protein.

Toll-like receptor 2 contributes to glial cell activation and heme oxygenase-1 expression in traumatic brain injury

2008 ◽  
Vol 431 (2) ◽  
pp. 123-128 ◽  
Author(s):  
Chanhee Park ◽  
Ik-Hyun Cho ◽  
Donghoon Kim ◽  
Eun-Kyeong Jo ◽  
Se-Young Choi ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Glial Cell ◽  
Heme Oxygenase ◽  
Cell Activation ◽  
Heme Oxygenase 1 ◽  
Toll Like Receptor ◽  
Glial Cell Activation ◽  
Toll Like Receptor 2

scholarly journals Neuroinflammation and glial cell activation in mental disorders

2020 ◽  
Vol 2 ◽  
pp. 100034 ◽  
Author(s):  
Priscila G.C. Almeida ◽  
João Victor Nani ◽  
Jean Pierre Oses ◽  
Elisa Brietzke ◽  
Mirian A.F. Hayashi
Keyword(s):  
Mental Disorders ◽  
Glial Cell ◽  
Cell Activation ◽  
Glial Cell Activation

scholarly journals Activation of σ1 and σ2 receptors by afobazole increases glial cell survival and prevents glial cell activation and nitrosative stress after ischemic stroke

2016 ◽  
Vol 139 (3) ◽  
pp. 497-509 ◽  
Author(s):  
Christopher Katnik ◽  
Angela Garcia ◽  
Adam A. Behensky ◽  
Ilya E. Yasny ◽  
Alex M. Shuster ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Cell Survival ◽  
Glial Cell ◽  
Cell Activation ◽  
Nitrosative Stress ◽  
Glial Cell Activation

scholarly journals Tauroursodeoxycholic acid reduces glial cell activation in an animal model of acute neuroinflammation

2014 ◽  
Vol 11 (1) ◽  
pp. 50 ◽  
Author(s):  
Natalia Yanguas-Casás ◽  
M Barreda-Manso ◽  
Manuel Nieto-Sampedro ◽  
Lorenzo Romero-Ramírez
Keyword(s):  
Animal Model ◽  
Glial Cell ◽  
Cell Activation ◽  
Tauroursodeoxycholic Acid ◽  
Glial Cell Activation

Toll-Like Receptor 2-Mediated Glial Cell Activation in a Mouse Model of Cuprizone-Induced Demyelination

2017 ◽  
Vol 55 (8) ◽  
pp. 6237-6249 ◽  
Author(s):  
Stefan Esser ◽  
Larissa Göpfrich ◽  
Kai Bihler ◽  
Eugenia Kress ◽  
Stella Nyamoya ◽  
...  
Keyword(s):  
Mouse Model ◽  
Glial Cell ◽  
Cell Activation ◽  
Toll Like Receptor ◽  
Glial Cell Activation ◽  
Toll Like Receptor 2

Aucubin alleviates glial cell activation and preserves dopaminergic neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonian mice

Neuroreport ◽  
2018 ◽  
Vol 29 (13) ◽  
pp. 1075-1083 ◽  
Author(s):  
Ying-Li Zhu ◽  
Meng-Fei Sun ◽  
Xue-Bing Jia ◽  
Pei-Hao Zhang ◽  
Yi-Da Xu ◽  
...  
Keyword(s):  
Glial Cell ◽  
Dopaminergic Neurons ◽  
Cell Activation ◽  
Glial Cell Activation

scholarly journals Imaging of Glial Cell Activation and White Matter Integrity in Brains of Active and Recently Retired National Football League Players

2017 ◽  
Vol 74 (1) ◽  
pp. 67 ◽  
Author(s):  
Jennifer M. Coughlin ◽  
Yuchuan Wang ◽  
Il Minn ◽  
Nicholas Bienko ◽  
Emily B. Ambinder ◽  
...  
Keyword(s):  
White Matter ◽  
Glial Cell ◽  
Cell Activation ◽  
National Football League ◽  
White Matter Integrity ◽  
Glial Cell Activation
Sign in / Sign up

Export Citation Format

Share Document