scholarly journals Chronic effects of nebivolol on arterial blood pressure and LV function in patients with moderate to severe arterial hypertension

2001 ◽  
Vol 14 (11) ◽  
pp. A108
Author(s):  
A L'Abbate
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Arterial Blood Pressure ◽  
Lv Function ◽  
Arterial Blood ◽  
Chronic Effects

scholarly journals Hemodynamic Effects of Alpha-Tropomyosin Mutations Associated with Inherited Cardiomyopathies: Multiscale Simulation

Mathematics ◽  
2020 ◽  
Vol 8 (7) ◽  
pp. 1169
Author(s):  
Fyodor Syomin ◽  
Albina Khabibullina ◽  
Anna Osepyan ◽  
Andrey Tsaturyan
Keyword(s):  
Blood Pressure ◽  
Arterial Blood Pressure ◽  
Heart Function ◽  
Systolic Pressure ◽  
Multiscale Model ◽  
Multiscale Simulation ◽  
Lv Function ◽  
Arterial Blood ◽  
Volume Relation ◽  
Heart Contractility

The effects of two cardiomyopathy-associated mutations in regulatory sarcomere protein tropomyosin (Tpm) on heart function were studied with a new multiscale model of the cardiovascular system (CVS). They were a Tpm mutation, Ile284Val, associated with hypertrophic cardiomyopathy (HCM), and an Asp230Asn one associated with dilated cardiomyopathy (DCM). When the molecular and cell-level changes in the Ca2+ regulation of cardiac muscle caused by these mutations were introduced into the myocardial model of the left ventricle (LV) while the LV shape remained the same as in the model of the normal heart, the cardiac output and arterial blood pressure reduced. Simulations of LV hypertrophy in the case of the Ile284Val mutation and LV dilatation in the case of the Asp230Asn mutation demonstrated that the LV remodeling partially recovered the stroke volume and arterial blood pressure, confirming that both hypertrophy and dilatation help to preserve the LV function. The possible effects of changes in passive myocardial stiffness in the model according to data reported for HCM and DCM hearts were also simulated. The results of the simulations showed that the end-systolic pressure–volume relation that is often used to characterize heart contractility strongly depends on heart geometry and cannot be used as a characteristic of myocardial contractility.

scholarly journals The status of element homeostasis in children and adolescents with essential arterial hypertension

2012 ◽  
Vol 93 (2) ◽  
pp. 184-190
Author(s):  
T P Makarova ◽  
Z R Khabibrakhmanova ◽  
D I Sadykova ◽  
Yu M Chilikina
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Blood Serum ◽  
Children And Adolescents ◽  
Arterial Blood Pressure ◽  
Childhood And Adolescence ◽  
Functional Variants ◽  
Arterial Blood ◽  
Essential Arterial Hypertension ◽  
Metabolic Type

Aim. To study the features of element homeostasis in children and adolescents with different variants of essential arterial hypertension. Methods. The clinical and functional variant of arterial hypertension was established based on the data of 24-hour monitoring of the arterial blood pressure. Investigation of the element content in the blood serum and daily urine was performed using the method of atomic absorption spectrophotometry. The clearance and the excreted fraction of the investigated elements were measured. Results. Revealed was an increase of the content of lead in the blood serum, an increase in lead excretion with urine, an increase in its clearance and excreted fraction in patients with stable arterial hypertension. It has been shown that for children and adolescents with a variety of clinical and functional variants of arterial hypertension characteristic is an excess of the serum content of a toxic element (lead) over the content of an essential element (zinc), and these changes are most pronounced in the group with stable arterial hypertension. In children and adolescents with the increase in arterial blood pressure registered was a decrease in the content of zinc and magnesium in the blood serum, whereas the disturbances of element homeostasis relate to the metabolic type. The increase in the content of copper and calcium in blood serum of patients with high blood pressure is also a manifestation of the metabolic type of element homeostasis disturbances. Conclusion. The increased level of lead in blood serum in combination with its enhanced excretion may be a cofactor in the development of essential arterial hypertension in childhood and adolescence.

Systemic Haemodynamics in Mild Arterial Hypertension before and after Physical Training

1973 ◽  
Vol 45 (s1) ◽  
pp. 145s-149s ◽  
Author(s):  
R. Sannerstedt ◽  
H. Wasir ◽  
R. Henning ◽  
L. Werkö
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Arterial Hypertension ◽  
Arterial Blood Pressure ◽  
Physical Training ◽  
Blood Pressure Level ◽  
Work Load ◽  
Physical Conditioning ◽  
Arterial Blood ◽  
Before And After

1. Five men with borderline, latent arterial hypertension of the hyperkinetic type were studied haemodynamically at rest and during dynamic exercise before and after a 6-week period of supervised physical training. 2. Tendencies to lower heart rate, cardiac output and arterial blood pressure, both at rest and during a standardized work-load, were observed after the training period, with significant differences between paired observations for the heart rate and mean arterial blood pressure during exercise. The systemic vascular resistance being unchanged, there was a certain trend to an increased widening of the arteriovenous oxygen difference, both at rest and during exercise. 3. The present findings from a small number of subjects indicate that physical conditioning of patients with latent hypertension of the hyperkinetic type contributes to a normalization of their circulation toward a normokinetic one, thereby also normalizing their blood pressure level and achieving a more economic energy expenditure in the cardiovascular system.

scholarly journals INFLUENCE OF SHORT-TERM AIR POLLUTION WITH CARBON MONOXIDE ON THE RISK OF AMBULANCE CALL-OUTS RELATED TO ARTERIAL HYPERTENSION / TRUMPALAIKIS ORO TARŠOS ANGLIES MONOKSIDU POVEIKIS GREITOSIOS MEDICINOS PAGALBOS IŠKVIETIMŲ DĖL ARTERINĖS HIPERTENZIJOS RIZIKA

2015 ◽  
Vol 7 (4) ◽  
pp. 385-391 ◽  
Author(s):  
Agnė Brazienė ◽  
Jonė Venclovienė ◽  
Rūta Babarskienė ◽  
Tautvydė Danilčikaitė
Keyword(s):  
Blood Pressure ◽  
Air Pollution ◽  
Carbon Monoxide ◽  
Arterial Hypertension ◽  
Arterial Blood Pressure ◽  
Air Temperature ◽  
Negative Influence ◽  
Short Term ◽  
Arterial Blood ◽  
Negative Effect

Air pollution by carbon monoxide can be possibly related to the increase in arterial blood pressure and the risk of arterial hypertension. The study was made in Kaunas. The concentration of daily carbon monoxide was estimated according to the data provided by the Department of Environment of Kaunas and environmental monitoring stations of Kaunas city municipality. The study aims to determine a short-term impact of air pollution by carbon monoxide on the number of calls for ambulance due to the risk of arterial hypertension. The following factors were taken into consideration during the study: the time of calling for ambulance, seasons, weekdays and air temperature. Almost half of calls for ambulance (45.1%) due to the increase in arterial blood pressure were recorded in the afternoon (from 0 to 15 calls a day). The number of calls for ambulance due to the increase in arterial blood pressure was the lowest in the warmest time of the year (summer) regardless of the time of the day, and the highest in winter (in the afternoon and evening). The number of calls for ambulance at night due to the increase in arterial blood pressure was significantly higher on Mondays and Tuesdays. The number of calls for ambulance was 14% lower in the afternoon when the air temperature was 10 oC and 13% lower in the evening and at night. The number of calls for ambulance due to the increase in arterial blood pressure can be related to increased concentration of carbon monoxide one day before the call for ambulance (as a result of increased concentration of carbon monoxide by 1 mg/m3, the risk increases by 1.24 times). Increased concentration of carbon monoxide did not have negative influence on the number of calls for ambulance. Negative effect of carbon monoxide was observed when daily carbon concentration exceeded 80th percentile (0.583 mg/m3). Oro tarša anglies monoksidu, tikėtina, susijusi su arterinio kraujo spaudimo padidėjimu bei arterinės hipertenzijos išsivystymo rizika. Tyrimas atliktas Kaune, paros anglies monoksido koncentracija vertinta pagal Kauno regiono aplinkos apsaugos departamento ir miesto savivaldybės ekologinio monitoringo stotyse išmatuotus duomenis. Tyrimo tikslas – nustatyti trumpalaikį oro taršos anglies monoksidu poveikį greitosios medicinos pagalbos iškvietimų dėl arterinės hipertenzijos rizikai, atsižvelgiant į iškvietimo laiką ir kontroliuojant sezoniškumo, savaitės dienos bei oro temperatūros įtaką. Beveik pusė iškvietimų (45,1 %) dėl arterinio kraujo spaudimo padidėjimo buvo registruojami popietinėmis valandomis (nuo 0 iki 15 iškvietimų per parą). Šilčiausiu metų laiku (vasarą) iškvietimų skaičius dėl arterinio kraujospūdžio padidėjimo nepriklausomai nuo paros meto buvo mažiausias, o didžiausias – žiemą (po pietų ir vakare). Nakties metu iškvietimų rizika dėl padidėjusio arterinio kraujo spaudimo buvo žymiai didesnė pirmadieniais ir antradieniais. Iškvietimo parą oro temperatūrai pakilus 10 ºC greitosios medicinos pagalbos iškvietimų rizika buvo 14 % mažesnė popietinėmis valandomis bei 13 % mažesnė vakare ir naktį. Iškvietimų dėl padidėjusio arterinio kraujospūdžio ryte rizika sietina su padidėjusia anglies monoksido koncentracija parą prieš iškvietimą (padidėjus anglies monoksido koncentracijai 1 mg/m3, rizika padidėja 1,24 karto). Padidėjusi anglies monoksido koncentracija neigiamos įtakos iškvietimams neturėjo. Neigiamas anglies monoksido poveikis stebėtas paros koncentracijai viršijus 80 procentilių (0,583 mg/m3).

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