scholarly journals The impact of schizotypy on pragmatics

2020 ◽  
Vol 62 ◽  
pp. e020014
Author(s):  
Monica de Freitas Frias Chaves ◽  
Cilene Rodrigues
Keyword(s):  
Personality Traits ◽  
Contextual Information ◽  
Brazilian Portuguese ◽  
Schizophrenia Spectrum Disorders ◽  
Semantic Meaning ◽  
General Hypothesis ◽  
Schizotypal Personality ◽  
Schizophrenia Spectrum ◽  
Spectrum Disorders ◽  
The Impact

High levels of linguistic referential failures are associated with liability to develop schizophrenia-spectrum disorders, and it has been shown that these failures can differentiate healthy subjects, high-schizotypal and schizophrenics groups. Nevertheless, few investigations have focused on whether or not schizotypal traits in nonclinical populations can also impact linguistic reference. In Brazilian Portuguese, only one previous study (acceptability judgements task) had been conducted, and its results suggest association between schizotypal traits and a more rigid preference for assignment of specific readings to definite singular DPs. Here, we present another experimental study in Brazilian Portuguese,  a comprehension task designed to examine possible effects of schizotypal personality traits on the interpretation of definite singular DPs. The findings, in line with the previous results, support the conclusion that schizotypy does affect the interpretation of definite singular DPs in Brazilian Portuguese. Together, these two experiments suggest that schizotypal personality traits impact the integration of linguistic contextual information into the semantic meaning of definite DPs. This is  consistent with the general hypothesis that schizotypy, similarly to schizophrenia, is associated with pragmatic difficulties. Yet, our results emphasize that the impact of schizotypal traits on pragmatics can be observed even in healthy (nonclinical) speakers.

scholarly journals Understanding the Influence of Personality Traits on Risk of Suicidal Behaviour in Schizophrenia Spectrum Disorders: A Systematic Review

2021 ◽  
Vol 10 (19) ◽  
pp. 4604
Author(s):  
Manuel Canal-Rivero ◽  
Rosa Ayesa-Arriola ◽  
Esther Setién-Suero ◽  
Benedicto Crespo-Facorro ◽  
Celso Arango ◽  
...  
Keyword(s):  
Systematic Review ◽  
Personality Traits ◽  
Suicidal Behaviour ◽  
Selection Criteria ◽  
Schizophrenia Spectrum Disorders ◽  
Related Factors ◽  
Schizotypal Personality ◽  
Premature Deaths ◽  
Schizophrenia Spectrum ◽  
Spectrum Disorders

Risk of suicidal behaviour (SB) in schizophrenia spectrum disorders (SSD) is a major concern, particularly in early stages of the illness, when suicide accounts for a high number of premature deaths. Although some risk factors for SB in SSD are well understood, the extent to which personality traits may affect this risk remains unclear, which may have implications for prevention. We conducted a systematic review of previous studies indexed in MEDLINE, PsycINFO and Embase examining the relationship between personality traits and SB in samples of patients with SSD. Seven studies fulfilled predetermined selection criteria. Harm avoidance, passive-dependent, schizoid and schizotypal personality traits increased the risk of SB, while self-directedness, cooperativeness, excluding persistence and self-transcendence acted as protective factors. Although only seven studies were retrieved from three major databases after applying predetermined selection criteria, we found some evidence to support that personality issues may contribute to SB in patients with SSD. Personality traits may therefore become part of routine suicide risk assessment and interventions targeting these personality-related factors may contribute to prevention of SB in SSD.

scholarly journals A Randomized Clinical Trial of Oxytocin or Galantamine in Schizophrenia: Assessing the Impact on Behavioral, Lexical, and Self-Report Indicators of Social Affiliation

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Kristen R Dwyer ◽  
Alexandra M Andrea ◽  
Christina L G Savage ◽  
Ryan D Orth ◽  
LeeAnn Shan ◽  
...  
Keyword(s):  
Negative Symptoms ◽  
Controlled Trial ◽  
Self Report ◽  
Schizophrenia Spectrum Disorders ◽  
Social Affiliation ◽  
Subjective Responses ◽  
Randomized Controlled ◽  
Schizophrenia Spectrum ◽  
Spectrum Disorders ◽  
The Impact

Abstract Prior studies examining the impact of oxytocin on negative symptoms in schizophrenia have yielded mixed results. The current study explored whether oxytocin can improve more proximal indicators of social affiliation as indicated by changes in behavior, language and subjective indices of social affiliation among individuals with schizophrenia spectrum disorders during a role-play designed to elicit affiliative responses. We tested the hypothesis that daily intranasal oxytocin administered for 6 weeks would improve social affiliation as manifested by increased social skill ratings, use of positive, affiliative, and social words, and subjective responses from a previously published randomized controlled trial. Forty outpatients with schizophrenia or schizoaffective disorder were randomized to the oxytocin, galantamine, or placebo group and completed affiliative role-plays and self-report questionnaires of affect, reactions to the affiliative confederate, and willingness to interact at baseline and post-treatment. Results demonstrated that oxytocin was not effective at improving behavioral or subjective indicators of social affiliation. This study adds to a growing literature that the prosocial effects of oxytocin in schizophrenia are limited or null.

scholarly journals How do ethnicity and deprivation impact on life expectancy at birth in people with serious mental illness? Observational study in the UK

2020 ◽  
pp. 1-9
Author(s):  
Jayati Das-Munshi ◽  
Chin-Kuo Chang ◽  
Alex Dregan ◽  
Stephani L. Hatch ◽  
Craig Morgan ◽  
...  
Keyword(s):  
General Population ◽  
Life Expectancy ◽  
Bipolar Disorders ◽  
Mental Illnesses ◽  
Schizophrenia Spectrum Disorders ◽  
Life Expectancy At Birth ◽  
Schizophrenia Spectrum ◽  
Spectrum Disorders ◽  
The Impact ◽  
Deprived Areas

Abstract Background Across international contexts, people with serious mental illnesses (SMI) experience marked reductions in life expectancy at birth. The intersection of ethnicity and social deprivation on life expectancy in SMI is unclear. The aim of this study was to assess the impact of ethnicity and area-level deprivation on life expectancy at birth in SMI, defined as schizophrenia-spectrum disorders, bipolar disorders and depression, using data from London, UK. Methods Abridged life tables to calculate life expectancy at birth, in a cohort with clinician-ascribed ICD-10 schizophrenia-spectrum disorders, bipolar disorders or depression, managed in secondary mental healthcare. Life expectancy in the study population with SMI was compared with life expectancy in the general population and with those residing in the most deprived areas in England. Results Irrespective of ethnicity, people with SMI experienced marked reductions in life expectancy at birth compared with the general population; from 14.5 years loss in men with schizophrenia-spectrum and bipolar disorders, to 13.2 years in women. Similar reductions were noted for people with depression. Across all diagnoses, life expectancy at birth in people with SMI was lower than the general population residing in the most deprived areas in England. Conclusions Irrespective of ethnicity, reductions in life expectancy at birth among people with SMI are worse than the general population residing in the most deprived areas in England. This trend in people with SMI is similar to groups who experience extreme social exclusion and marginalisation. Evidence-based interventions to tackle this mortality gap need to take this into account.

Schizophrenia–schizoaffective–bipolar spectra: an epistemological perspective

CNS Spectrums ◽  
2019 ◽  
pp. 1-5
Author(s):  
João Gama Marques ◽  
Sílvia Ouakinin
Keyword(s):  
Personality Traits ◽  
Schizophrenia Spectrum Disorders ◽  
Epistemological Perspective ◽  
Schizophrenia Spectrum ◽  
Spectrum Disorders ◽  
Different Levels

AbstractFor decades clinicians and researchers have been thinking and writing about the spectrum of schizophrenia disorders. Indeed both Kraepelin and Bleuler believed in schizophrenia as a spectrum, both in a clinical (individual) and hereditary (family) continuum, from just some exquisite personality traits to unquestionable chronic and debilitating psychosis. Other authors would put the schizophrenia spectrum disorders on different levels of continuum: developmental, psychofunctional, existential, and genetic. Here, we would like to present an historical chronology for the schizophrenia–schizoaffective–bipolar spectra plus a tridimensional model for these spectra: the first axis for categories (affective versus nonaffective psychoses), the second axis for dimensions (personality versus full blown psychosis), and a third axis for biomarkers (remission versus relapse). We believe that without the schizophrenia–schizoaffective–bipolar spectra concept in our minds all our efforts will keep failing one the hardest quest: searching for biomarkers in schizophrenia and related disorders.

scholarly journals The Impact of Sex Differences on Odor Identification and Facial Affect Recognition in Patients with Schizophrenia Spectrum Disorders

2018 ◽  
Vol 9 ◽  
Author(s):  
Nilufar Mossaheb ◽  
Rainer M. Kaufmann ◽  
Monika Schlögelhofer ◽  
Thushara Aninilkumparambil ◽  
Claudia Himmelbauer ◽  
...  
Keyword(s):  
Sex Differences ◽  
Facial Affect ◽  
Odor Identification ◽  
Affect Recognition ◽  
Facial Affect Recognition ◽  
Schizophrenia Spectrum Disorders ◽  
Schizophrenia Spectrum ◽  
Spectrum Disorders ◽  
The Impact

The Relationship Between Multisensory Temporal Processing and Schizotypal Traits

2020 ◽  
Author(s):  
Tyler C. Dalal ◽  
Anne-Marie Muller ◽  
Ryan A Stevenson
Keyword(s):  
Temporal Processing ◽  
Temporal Order Judgment ◽  
Judgment Task ◽  
Schizophrenia Spectrum Disorders ◽  
Magical Thinking ◽  
Schizotypal Personality ◽  
Schizophrenia Spectrum ◽  
Schizotypal Personality Questionnaire ◽  
Spectrum Disorders ◽  
The Relationship

Recent literature has suggested that atypical sensory processing observed in schizophrenia may contribute to clinical symptomatology. Specifically, multisensory temporal processing was shown to be strongly associated with hallucination severity. Here, we explored whether this relationship extends to a broader spectrum of schizotypal traits, in line with the DSM-5’s shift towards a more dimensional approach to diagnostic criteria within Schizophrenia Spectrum Disorders. Fifty-one participants completed an audiovisual temporal order judgment task as a measure of multisensory temporal processing and self-reported levels of schizotypal traits using the Schizotypal Personality Questionnaire. These data revealed two novel findings. First, less precise multisensory temporal processing was related to higher overall levels of schizotypal traits. Second, this relationship was specific to the cognitive-perceptual domain, and more specifically, the Unusual Perceptual Experiences and Odd Beliefs or Magical Thinking measures. Previous literature has shown that less precise multisensory temporal processing was related to the severity of hallucinations in schizophrenia. These findings provide a novel, direct extension of this previous work by demonstrating that this relationship applies to traits across the schizophrenia spectrum, including at the subclinical level.

scholarly journals The Role of Dopaminergic Genes in Probabilistic Reinforcement Learning in Schizophrenia Spectrum Disorders

2021 ◽  
Vol 12 (1) ◽  
pp. 7
Author(s):  
Dorota Frydecka ◽  
Błażej Misiak ◽  
Patryk Piotrowski ◽  
Tomasz Bielawski ◽  
Edyta Pawlak ◽  
...  
Keyword(s):  
Reinforcement Learning ◽  
Genetic Polymorphisms ◽  
Schizophrenia Spectrum Disorders ◽  
Schizophrenia Spectrum ◽  
Probabilistic Reinforcement ◽  
Healthy Control ◽  
Spectrum Disorders ◽  
The Impact ◽  
Dopaminergic Genes ◽  
Allele Repeat

Schizophrenia spectrum disorders (SZ) are characterized by impairments in probabilistic reinforcement learning (RL), which is associated with dopaminergic circuitry encompassing the prefrontal cortex and basal ganglia. However, there are no studies examining dopaminergic genes with respect to probabilistic RL in SZ. Thus, the aim of our study was to examine the impact of dopaminergic genes on performance assessed by the Probabilistic Selection Task (PST) in patients with SZ in comparison to healthy control (HC) subjects. In our study, we included 138 SZ patients and 188 HC participants. Genetic analysis was performed with respect to the following genetic polymorphisms: rs4680 in COMT, rs907094 in DARP-32, rs2734839, rs936461, rs1800497, and rs6277 in DRD2, rs747302 and rs1800955 in DRD4 and rs28363170 and rs2975226 in DAT1 genes. The probabilistic RL task was completed by 59 SZ patients and 95 HC subjects. SZ patients performed significantly worse in acquiring reinforcement contingencies during the task in comparison to HCs. We found no significant association between genetic polymorphisms and RL among SZ patients; however, among HC participants with respect to the DAT1 rs28363170 polymorphism, individuals with 10-allele repeat genotypes performed better in comparison to 9-allele repeat carriers. The present study indicates the relevance of the DAT1 rs28363170 polymorphism in RL in HC participants.

scholarly journals Schizotypy and brain structure: a voxel-based morphometry study

2009 ◽  
Vol 40 (9) ◽  
pp. 1423-1431 ◽  
Author(s):  
G. Modinos ◽  
A. Mechelli ◽  
J. Ormel ◽  
N. A. Groenewold ◽  
A. Aleman ◽  
...  
Keyword(s):  
Gray Matter Volume ◽  
Chronic Schizophrenia ◽  
Posterior Cingulate Cortex ◽  
Self Report ◽  
Schizophrenia Spectrum Disorders ◽  
Voxel Based Morphometry ◽  
Schizotypal Personality ◽  
Psychosis Proneness ◽  
Schizophrenia Spectrum ◽  
Spectrum Disorders

BackgroundSchizotypy is conceptualized as a subclinical manifestation of the same underlying biological factors that give rise to schizophrenia and other schizophrenia spectrum disorders. Individuals with psychometric schizotypy (PS) experience subthreshold psychotic signs and can be psychometrically identified among the general population. Previous research using magnetic resonance imaging (MRI) has shown gray-matter volume (GMV) abnormalities in chronic schizophrenia, in subjects with an at-risk mental state (ARMS) and in individuals with schizotypal personality disorder (SPD). However, to date, no studies have investigated the neuroanatomical correlates of PS.MethodSix hundred first- and second-year university students completed the Community Assessment of Psychic Experiences (CAPE), a self-report instrument on psychosis proneness measuring attenuated positive psychotic experiences. A total of 38 subjects with high and low PS were identified and subsequently scanned with MRI. Voxel-based morphometry (VBM) was applied to examine GMV differences between subjects with high and low positive PS.ResultsSubjects with high positive PS showed larger global volumes compared to subjects with low PS, and larger regional volumes in the medial posterior cingulate cortex (PCC) and the precuneus. There were no regions where GMV was greater in low than in high positive PS subjects.ConclusionsThese regions, the PCC and precuneus, have also been sites of volumetric differences in MRI studies of ARMS subjects and schizophrenia, suggesting that psychotic or psychotic-like experiences may have common neuroanatomical correlates across schizophrenia spectrum disorders.

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