378P Outcomes of p 16 positive oropharyngeal squamous cell carcinoma treated with radiotherapy - Results from a tertiary care center in South India

Background: Eyelid lesions are commonly encountered in histopathology practice and encompass a wide variety of non-neoplastic and neoplastic lesions. Here we report the histopathological features of eyelid lesions in patients presenting to a tertiary care center in Kerala, South India.Methods: In this retrospective study, a total of 414 eyelid lesions were identified over a period of 10 years (January 2006 - December 2015). In each case, details including age, gender and final histopathological diagnosis were recorded from histopathology registers.Results: Non-neoplastic lesions (52.4%) were more common than neoplastic lesions (47.6%). In the neoplastic lesions, benign tumors outnumbered (37.7%) malignant tumors (9.9%). Age of patients ranged from 1 to 90 years with a mean age of 43.4 years. M: F ratio was 1:1.3. The most common non-neoplastic lesion was epidermal cyst (14.3%) followed by parasitic granuloma (9.2%), chalazion and dermoid cyst (5.6% each). Nevus was the commonest benign eyelid tumor (13.7%) followed by squamous papilloma (9.2%), seborrhoeic keratosis and capillary hemangioma (3.9% each). Sebaceous carcinoma was the most frequent malignant tumor (2.4%) followed by squamous cell carcinoma (2.2%) and basal cell carcinoma (1.5%). Uncommon lesions encountered were actinomycosis, tuberculous granuloma, amyloid deposit, calcinosis cutis, molluscum, angiolymphoid hyperplasia with eosinophilia, xanthelasma, granular cell tumor, benign fibrous histiocytoma, mucinous eccrine adenocarcinoma etc.Conclusions: Eyelid lesions were commoner in females and in 5th and 6th decades. Epidermal cyst and nevus were the commonest benign lesions and sebaceous carcinoma was the most common malignant tumor. The results are comparable with available data from South India.

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Human Papillomavirus Vaccination Counseling in Pediatric Training

Otolaryngology ◽

10.1177/0194599816639932 ◽

2016 ◽

Vol 155 (1) ◽

pp. 87-93 ◽

Cited By ~ 8

Author(s):

Sharon H. Gnagi ◽

Forrest T. Gnagi ◽

Scott A. Schraff ◽

Michael L. Hinni

Keyword(s):

Squamous Cell Carcinoma ◽

Human Papillomavirus ◽

Cell Carcinoma ◽

Squamous Cell ◽

Online Survey ◽

Hpv Vaccination ◽

Tertiary Care ◽

Recurrent Respiratory Papillomatosis ◽

Oropharyngeal Squamous Cell Carcinoma ◽

Human Papillomavirus Vaccination

Objective Demonstrate the need for increased education regarding otolaryngology-related manifestations of human papillomavirus (HPV). Highlight a need to incorporate otolaryngology-related manifestations of HPV in vaccine counseling. Study Design Survey. Setting Tertiary care academic children’s hospital. Subjects Pediatric residents, fellows, and staff. Methods An online survey was made available regarding HPV education and vaccination. Results Participants (N = 348) initiated the survey representing 28.4%, 25.6%, and 19.0% postgraduate year 1, 2, and 3 residents, respectively, as well as 17.5% chief residents/fellows and 9.5% attendings. Participants rated their prior education as none or fair regarding recurrent respiratory papillomatosis (63.8%) and oropharyngeal squamous cell carcinoma (68.3%). In contrast, 60.6% and 70.9% rated their education on genital warts and cervical cancer correspondingly as good or excellent. When asked what was routinely discussed during HPV vaccine counseling, 63.3% reported “never” discussing recurrent respiratory papillomatosis and 52.9% “never” discussing oropharyngeal squamous cell carcinoma. A range from 92.7% to 95.5% responded that there was a need for increased education regarding HPV and its role in recurrent respiratory papillomatosis and oropharyngeal squamous cell carcinoma. Conclusions Increased education about HPV and its otolaryngology-related manifestations should be undertaken to increase provider, patient, and parent awareness of recurrent respiratory papillomatosis and oropharyngeal squamous cell carcinoma. We propose that discussing the risks of otolaryngology-related disease be routinely included in HPV vaccination counseling.

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Apoptotic Count as a Guide for Histological Grading of Carcinoma Esophagus: A Light Microscopic Study

Journal of Laboratory Physicians ◽

10.4103/0974-2727.54801 ◽

2009 ◽

Vol 1 (01) ◽

pp. 011-014 ◽

Cited By ~ 1

Author(s):

Ankit Seth ◽

Asha Agarwal

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Histological Grade ◽

Care Center ◽

Tertiary Care ◽

P Value ◽

Histological Grading ◽

Carcinoma Of The Esophagus ◽

Carcinoma Of Esophagus

ABSTRACT Background: Many studies have been done in the past on the correlation between apoptotic count and histological grading of different tumors. Aims: The study aims to find out if a correlation between apoptotic count and histological grading exists in squamous cell carcinoma of the esophagus, and also to review the literature on such a relationship in the context of some other tumors. Settings and Design: Cases of squamous cell carcinoma of the esophagus who presented at a tertiary care center over a period of one year were reviewed. Materials and Methods: The endoscopic biopsy specimens of 56 patients of squamous cell carcinoma of esophagus were fixed in 10% buffered formalin, processed for routine paraffin sections, sections taken, stained by hematoxylin and eosin and examined under light microscope, using 40x objective and 10x eyepiece. Apoptotic bodies were counted in each high-power field (HPF). Statistical Analysis Used: Standard error of difference in apoptotic count in different tumor groups found and P value calculated, using Student′s t test. Results: An inverse correlation of the apoptotic count per HPF with the histological grade of the tumor was found. Conclusions: Grading of squamous cell carcinoma of esophagus, solely on the basis of apoptotic count can be used in the first place or to corroborate conventional histological grading done on the basis of morphology.

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Cost Considerations in the Treatment of Oropharyngeal Squamous Cell Carcinoma

Otolaryngology ◽

10.1177/0194599812437534 ◽

2012 ◽

Vol 146 (6) ◽

pp. 946-951 ◽

Cited By ~ 31

Author(s):

Eric J. Moore ◽

Michael L. Hinni ◽

Kerry D. Olsen ◽

Daniel L. Price ◽

Rebecca R. Laborde ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Tertiary Care ◽

Chemoradiation Therapy ◽

Oropharyngeal Squamous Cell Carcinoma ◽

Teaching Hospitals ◽

Adjuvant Radiation ◽

The Mean ◽

Mean Cost

Objectives. To determine the cost of treatment of oropharyngeal squamous cell carcinoma (OP SCCA) with transoral surgery with concomitant neck dissection (TOS), TOS with adjuvant radiation therapy (TOS + RT), TOS with adjuvant chemoradiation therapy (TOS + CRT), and primary chemoradiation therapy (CRT). Study Design. Case series. Setting. Two tertiary care teaching hospitals. Subjects and Methods. Using the databases of 2 teaching hospitals, patients were identified who had OP SCCA treated with TOS, TOS + RT, TOS + CRT, and primary CRT in 2009 to 2010. Costs were analyzed from an institutional perspective looking at reimbursement. Patients with government payers and patients with private payers in each group were identified, and net revenue data obtained for the 3-month period from diagnosis were calculated and averaged for each group. Cost was defined as the reimbursement for all charges surrounding the 3-month episode of treatment. All revenue associated with inpatient and outpatient care, including pharmacy charges, was included. Results. The mean cost of TOS (private payers/government payers) was $37,435/$15,664 (range, $22,486-$48,746/$13,325-$16,885). The mean cost of TOS + RT (private payers/government payers) was $74,484/$34,343 (range, $72,400-$84,825/$31,565-$40,810). The mean cost of TOS + CRT (private payers/government payers) was $191,780/$53,245 (range, $145,450-$217,220/$49,400-$58,325). The mean cost of CRT (private payers/government payers) was $198,285/$57,429 (range, $168,216-$298,945/$52,900-$59,545). Conclusion. An algorithm of transoral surgical treatment of OP SCCA with adjuvant treatment as indicated by pathology is more cost conscious than an algorithm of treatment of all OP SCCA with CRT.

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