Cutaneous Squamous Cell Carcinoma of the Forearm: Clinical Features and Outcomes at a Single Academic Tertiary Care Center in a Rural Setting

ABSTRACT Background: Many studies have been done in the past on the correlation between apoptotic count and histological grading of different tumors. Aims: The study aims to find out if a correlation between apoptotic count and histological grading exists in squamous cell carcinoma of the esophagus, and also to review the literature on such a relationship in the context of some other tumors. Settings and Design: Cases of squamous cell carcinoma of the esophagus who presented at a tertiary care center over a period of one year were reviewed. Materials and Methods: The endoscopic biopsy specimens of 56 patients of squamous cell carcinoma of esophagus were fixed in 10% buffered formalin, processed for routine paraffin sections, sections taken, stained by hematoxylin and eosin and examined under light microscope, using 40x objective and 10x eyepiece. Apoptotic bodies were counted in each high-power field (HPF). Statistical Analysis Used: Standard error of difference in apoptotic count in different tumor groups found and P value calculated, using Student′s t test. Results: An inverse correlation of the apoptotic count per HPF with the histological grade of the tumor was found. Conclusions: Grading of squamous cell carcinoma of esophagus, solely on the basis of apoptotic count can be used in the first place or to corroborate conventional histological grading done on the basis of morphology.

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Prognostic Factors in Metastatic Cutaneous Squamous Cell Carcinoma of the Head and Neck

Ear Nose & Throat Journal ◽

10.1177/0145561316095010-1106 ◽

2016 ◽

Vol 95 (10-11) ◽

pp. 1-10 ◽

Cited By ~ 2

Author(s):

Gideon Bachar ◽

Aviram Mizrachi ◽

Naomi Rabinovics ◽

Dan Guttman ◽

Thomas Shpitzer ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Independent Predictor ◽

Tertiary Care ◽

Prognostic Significance ◽

Cutaneous Squamous Cell Carcinoma ◽

Significant Difference ◽

Disease Free

Metastatic cutaneous squamous cell carcinoma (SCC) of the head and neck poses a significant therapeutic challengedue to its aggressive biologic behavior. We conducted a retrospective study of71 patients—58 men and 13 women, aged 28 to 88 years (mean: 71)—who had been treated atour university-affiliated tertiary care medical center for metastatic cutaneous SCCover a 15-year period. In addition to demographic data, we compiled and analyzed information on tumor characteristics, the site and extent of metastasis, treatment, follow-up, and outcome. Among the tumor factors, poorly differentiated carcinoma was an independent predictor of poorer disease-free survival, and olderage was found to be an independent predictor of poorer overall survival. We found no significant difference in disease-free or disease-specific survival among patients with parotid involvement, neck involvement, or both. In our series, the site of nodal involvement appeared to have no prognostic significance in patients with metastatic cutaneous SCC of the head and neck.

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Oncological outcomes in the management of cT1-T2 cN0 penile squamous cell carcinoma

Canadian Urological Association Journal ◽

10.5489/cuaj.6762 ◽

2020 ◽

Vol 15 (6) ◽

Author(s):

Juan Garisto ◽

Madhur Nayan ◽

Kamel Fadaak ◽

Kathy Li ◽

Advait Pandya ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Organ Preservation ◽

Early Stage ◽

Care Center ◽

Tertiary Care ◽

Oncological Outcome ◽

Treatment Modalities ◽

Tertiary Center

Introduction: Squamous cell carcinoma (SCC) of the penis is a rare disease comprising 1% of all male cancer. Options for the management of cT1-T2 cN0 penile SCC include partial penectomy (PP), considered the standard, and brachytherapy (BT), which offers acceptable local disease control and organ preservation. The purpose of our study was to assess and describe the oncological outcome for both treatments in a tertiary care center. Methods: We performed a contemporary retrospective study of patients with early-stage penile cancer treated surgically or by BT at a tertiary center between 2000 and 2016. Demographic, management, and followup data were obtained from an institutional database. Descriptive statistics and survival analysis using Kaplan-Meier plots were calculated. Local and regional recurrences were compared in both groups (BT vs. PP). Results: A total of 51 patients with cT1-T2N0 penile SCC treated with BT (35) and PP (16) were analyzed. Median followup was 37.1 (13.9–68) and 25.4 months (18–52.3) for the BT and PP group, respectively. Recurrence developed in seven (20%) patients treated with BT. Median time to recurrence was 35.2 months (range 2.9–95.8). No recurrences were reported in patients treated with PP. Forty-four (86.2%) patients were alive with no evidence of disease at the last followup. Overall survival was 62.7%. Complications after primary tumor treatment were urethral stenosis (15.7%), penile necrosis (7.8%), and local infection (2%). Conclusions: PP provides acceptable local control with organ preservation in early-stage penile SCC. BT was able to offer organ preservation in 69% of men. Future prospective studies are needed to compare other organ-conserving treatment modalities with PP.

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Treatment Outcomes of Patients with Squamous Cell Carcinoma of the Vulva: The Largest Series from a Tertiary Care Hospital

Obstetrics and Gynecology International ◽

10.1155/2018/4723167 ◽

2018 ◽

Vol 2018 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Panida Meelapkij ◽

Prapaporn Suprasert ◽

Orthai Baisai

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Care Center ◽

Combined Treatment ◽

Tertiary Care ◽

Underlying Disease ◽

Care Hospital ◽

Significant Difference ◽

The Common

Objective. To evaluate the outcomes of squamous cell carcinoma (SCCA) of the vulva treated at our tertiary care center. Methods. The medical records of SCCA patients treated between January 2006 and December 2015 were retrospectively reviewed. Results. One hundred forty-five patients met the criteria with the median age of 57 years old, and 58.6% had an underlying disease. The distribution of stages was as follows: IA 6.2%, IB 21.4%, II 26.2%, IIIA 14.5%, IIIB 6.2%, IIIC 9.7%, IVA 9.0%, and IVB 6.9%. One hundred and nine patients underwent surgical intervention and radical local excision with bilateral groin node dissection as the most frequent procedure. Approximately half of the patients received combined treatment with surgery followed by radiation with or without chemotherapy. Recurrence developed in 127 patients after the median follow-up time of one year with the common sites in the groin and vulva region. However, no significant difference in survival occurred in patients with and without groin node recurrence (15 vs. 28 months, P=0.109). The five-year overall survival was 50.8%. Conclusions. The survival of patients with SCCA vulvar cancer was modest. The common failure sites were groin and vulva regions with unfavorable outcomes.

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