In vitro antifungal activity of posaconazole against various pathogenic fungi

2001 ◽  
Vol 18 (2) ◽  
pp. 167-172 ◽  
Author(s):  
Katsuhisa Uchida ◽  
Nobuko Yokota ◽  
Hideyo Yamaguchi
Keyword(s):  
Antifungal Activity ◽  
Pathogenic Fungi ◽  
In Vitro Antifungal Activity

scholarly journals Chemical Composition and Antifungal Activity of the Essential Oil of Cotinus coggygria from Marche Region (Italy)

2018 ◽  
Vol 13 (9) ◽  
pp. 1934578X1801300 ◽  
Author(s):  
Daniele Fraternale ◽  
Donata Ricci
Keyword(s):  
Antifungal Activity ◽  
Essential Oil ◽  
Pathogenic Fungi ◽  
Gas Chromatography Mass Spectrometry ◽  
Dilution Method ◽  
Agar Dilution Method ◽  
Plant Pathogenic Fungi ◽  
Cotinus Coggygria ◽  
In Vitro Antifungal Activity

The present study reports the results of gas chromatography-mass spectrometry (GC/MS) analyses of the essential oil from flowering aerial parts of Cotinus coggygria Scoop. (Anacardiaceae), as well as its in vitro antifungal activity against nine plant pathogenic fungi. Moreover, the essential oil was evaluated for its antifungal activity using the agar dilution method, and also MICs (minimum inhibitory concentrations) and MFCs (minimum fungicidal concentrations) were determined. The major compounds identified by GC-MS were limonene (49.2%), (Z)-β-ocimene (13.6%), α-pinene (8.8%) and (E)-β-ocimene (5.9%). The oil showed in vitro antifungal activity against some species of the Fusarium genus, Botrytis cinerea, and Alternaria solani. Our study indicates that the oil of C. coggygria could be used as a control agent for plant pathogenic fungi in natural formulations.

scholarly journals Synthesis and Bio-Evaluation of Natural Butenolides-Acrylate Conjugates

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1304 ◽  
Author(s):  
Longzhu Bao ◽  
Shuangshuang Wang ◽  
Di Song ◽  
Jingjing Wang ◽  
Xiufang Cao ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Antifungal Activity ◽  
13C Nmr ◽  
Pathogenic Fungi ◽  
Phytopathogenic Fungi ◽  
Gibberella Zeae ◽  
Ionization Mass ◽  
Activity Screening ◽  
In Vitro Antifungal Activity

A series of novel 3-aryl-4-hydroxy-2(5H) furanone-acrylate hybrids were designed and synthesized based on the natural butenolides and acrylates scaffolds. The structures of the prepared compounds were characterized by 1H-NMR, 13C-NMR and electrospray ionization mass spectrometry (ESI-MS), and the bioactivity of the target compounds against twelve phytopathogenic fungi was investigated. The preliminary in vitro antifungal activity screening showed that most of the target compounds had moderate inhibition on various pathogenic fungi at the concentration of 100 mg·L−1, and presented broad-spectrum antifungal activities. Further studies also indicated that compounds 7e and 7k still showed some inhibitory activity against Pestallozzia theae, Sclerotinia sclerotiorum and Gibberella zeae on rape plants at lower concentrations, which could be optimized as a secondary lead for further research.

Antifungal action of chlorogenic acid against pathogenic fungi, mediated by membrane disruption

2010 ◽  
Vol 82 (1) ◽  
pp. 219-226 ◽  
Author(s):  
Woo Sang Sung ◽  
Dong Gun Lee
Keyword(s):  
Antifungal Activity ◽  
Chlorogenic Acid ◽  
Mode Of Action ◽  
Fungal Infections ◽  
Pathogenic Fungi ◽  
Membrane Dynamics ◽  
Independent Manner ◽  
Antifungal Action ◽  
In Vitro Antifungal Activity

Chlorogenic acid is a polyphenol compound, derived from several fruit and plants. The aim of this study was to assess the in vitro antifungal activity of chlorogenic acid and its mode of action. The results indicate that chlorogenic acid exhibits antifungal activities against certain pathogenic fungi in an energy-independent manner, without any hemolytic effect on human erythrocytes. To elucidate the antifungal mode of action of chlorogenic acid, flow cytometry analysis by using DiBAC4(3) and changes in membrane dynamics using 1,6-diphenyl-1,3,5-hexatriene (DPH) were performed with Candida albicans. The results suggest that chlorogenic acid may exert antifungal activity by disrupting the structure of the cell membrane. It is demonstrated that chlorogenic acid is a valid lead compound for the development of bioactive alternatives for treatment of fungal infections.

scholarly journals In vitro antifungal activity of cistus creticus l. against plant pathogenic fungi

2020 ◽  
Vol 58 (4) ◽  
pp. 413
Author(s):  
Ayşegül Çaşkurlu ◽  
Ayşe Esra Karadağ ◽  
Yavuz Bülent Köse ◽  
Fatma Tosun
Keyword(s):  
Antifungal Activity ◽  
Pathogenic Fungi ◽  
Plant Pathogenic Fungi ◽  
In Vitro Antifungal Activity ◽  
Cistus Creticus

scholarly journals Essential Oil Composition and Antifungal Activity of Aerial Parts of Ballota nigra ssp foetida Collected at Flowering and Fruiting Times

2014 ◽  
Vol 9 (7) ◽  
pp. 1934578X1400900 ◽  
Author(s):  
Daniele Fraternale ◽  
Donata Ricci
Keyword(s):  
Antifungal Activity ◽  
Essential Oils ◽  
Pathogenic Fungi ◽  
Dilution Method ◽  
Agar Dilution Method ◽  
Plant Pathogenic Fungi ◽  
Oil Composition ◽  
Aerial Parts ◽  
In Vitro Antifungal Activity

The present study reports the results of gas chromatographic-mass spectrometric (GC/MS) analyses of the essential oils from the aerial parts of Ballota nigra L. ssp foetida (Lamiaceae) collected at flowering and fruiting times, as well as their in vitro antifungal activity against nine plant pathogenic fungi. Moreover, the essential oils were evaluated for their antifungal activity using the agar dilution method, and also MICs (minimum inhibitory concentrations) and MFCs (minimum fungicidal concentrations) were determined. The major compounds identified in the flowering and fruiting aerial parts oils respectively were β-caryophyllene (22.6% and 21.8%), caryophyllene oxide (18.0% and 20.5%) and germacrene-D (16.5 and 13.1%). The oils showed in vitro antifungal activity against some species of Fusarium, Botrytis cinerea, and Alternaria solani. Our study indicates that the oil of B. nigra ssp foetida could be used as a control agent for plant pathogenic fungi in natural formulations.

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