Prevalence of Restless Legs Syndrome in Psychiatric Population

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
Z. Lattova ◽  
M. Keckeis ◽  
T. Pollmacher
Keyword(s):  
General Population ◽  
Restless Legs Syndrome ◽  
Psychotic Disorders ◽  
Psychiatric Inpatient ◽  
Positive Family History ◽  
Entire Sample ◽  
Sample Distribution ◽  
Restless Legs ◽  
Irls Score ◽  
Total Data

Objective:Restless Legs Syndrome (RLS) is a common condition, with reported prevalence between 1-15% in general population. To the best of our knowledge, there is no data on the prevalence of RLS in psychiatric inpatient population.Method:With the exception of drug/alcohol dependent and gerontopsychiatric patients, patients consecutively admitted to the Centre of Mental Health at the Klinikum Ingolstadt between December 2006 and March 2007 were interviewed by an experienced clinician to assess the presence of RLS. The severity of the symptoms was assessed by the International Restless Legs Severity Scale (IRLS).Results:214 patients were interviewed (age 45.6 ±14.8, 60% females). 22 patients (10.3%) fulfilled the diagnostic criteria for RLS (age 49.2 ±15.0, 73% females, mean IRLS score 20 ± 8.9). In addition, 6.3% of RLS symptoms free patients reported to have had these symptoms in the history. There were slightly more RLS patients diagnosed with an affective disorder compared to the entire sample distribution and there were considerably less RLS patients in the group of psychotic disorders. 4.3% of the total data sample had a positive family history for RLS. As assessed by simple regression analysis there were no particular differences in medication patters between RLS patients and the entire sample.Conclusion:We report here for the first time the prevalence of RLS in psychiatric inpatients. The prevalence rate is on the upper range of that reported for the general population. In addition, 6.3% of RLS symptoms free inpatients reported to have had these symptoms in the history.

scholarly journals The Safety and Efficacy of Pregabalin Add-on Therapy in Restless Legs Syndrome Patients

2021 ◽  
Vol 12 ◽  
Author(s):  
Hyoeun Bae ◽  
Yong Won Cho ◽  
Keun Tae Kim ◽  
Richard P. Allen ◽  
Christopher J. Earley
Keyword(s):  
Side Effects ◽  
Restless Legs Syndrome ◽  
Severity Index ◽  
Efficacy And Safety ◽  
Restless Legs ◽  
Persistent Symptoms ◽  
Before And After ◽  
Severity Index Score ◽  
Irls Score ◽  
Symptomatic Control

Pregabalin is increasingly being used as a first-line treatment for symptomatic control of restless legs syndrome (RLS). This study aimed to evaluate the efficacy and safety of pregabalin as add-on therapy in RLS patients already taking dopamine agonists (DA) but still in need of further management. Patients with idiopathic RLS were enrolled, and all had already been prescribed DA for at least 3 months but still had either persistent symptoms, side effects, or comorbid insomnia. An initial dose of 75 mg pregabalin was begun, adjusted as needed, and maintained at a stable dose for 4 weeks, followed by observation for a total of 8 weeks. RLS symptoms and insomnia scores were evaluated before and after add-on pregabalin treatment. Patients were monitored for side effects that could be attributed to pregabalin. A total of 32 RLS patients were enrolled, and 20 subjects remained until the endpoint. After the pregabalin add-on, the mean IRLS score showed significant improvement compared to the baseline (p < 0.001). The insomnia severity index score also improved (p = 0.036), and no serious adverse effects were observed. Our preliminary data suggests the potential for pregabalin as an add-on therapy to DA with regards to both efficacy and safety in patients who have inadequate RLS improvement.

Prevalence and Characteristics of Restless Legs Syndrome in Korean Adults: A Study in Two Independent Samples of the General Population

2019 ◽  
Vol 52 (3-4) ◽  
pp. 193-204 ◽  
Author(s):  
Tae-Joon Kim ◽  
Jee Eun Yoon ◽  
Jung A Park ◽  
Seung Ku Lee ◽  
Min Kyung Chu ◽  
...  
Keyword(s):  
General Population ◽  
Restless Legs Syndrome ◽  
Restless Legs ◽  
Korean Adults

scholarly journals Socio-economic risk factors for incident restless legs syndrome in the general population

2012 ◽  
Vol 21 (5) ◽  
pp. 561-568 ◽  
Author(s):  
ANDRAS SZENTKIRALYI ◽  
KONSTANZE FENDRICH ◽  
WOLFGANG HOFFMANN ◽  
SVENJA HAPPE ◽  
KLAUS BERGER
Keyword(s):  
Risk Factors ◽  
General Population ◽  
Restless Legs Syndrome ◽  
Economic Risk ◽  
Restless Legs

Latest Perspectives in Genetic Risk Factors for Restless Legs Syndrome

2013 ◽  
Vol 8 (2) ◽  
pp. 90 ◽  
Author(s):  
Félix Javier Jiménez-Jiménez ◽  
Hortensia Alonso-Navarro ◽  
Elena García-Martín ◽  
José AG Agûndez ◽  
◽  
...  
Keyword(s):  
Restless Legs Syndrome ◽  
Association Studies ◽  
Positive Family History ◽  
Twin Studies ◽  
Genome Wide Association Studies ◽  
Restless Legs ◽  
Genome Wide ◽  
History Of ◽  
High Concordance ◽  
Control Association

The high frequency of positive family history of restless legs syndrome (RLS) in patients with this disease and the observed high concordance rates in monozygotic compared with dizygotic twins support a major role of genetic factors in the development of RLS. Although a number of variants for several genes may increase the risk of RLS, no definitive causative genes have been identified to date. In this review, we summarise the studies performed on families with RLS, twin studies, linkage studies, genome-wide association studies, case-control association studies and exome sequencing in RLS. The strongest candidate genes are ofPTPRD, BTBD9andMEIS.

scholarly journals Impact of Positive Airway Pressure on International Restless Legs Syndrome Score in Sleep Disordered Breathing

2019 ◽  
Vol 8 (12) ◽  
pp. 2212
Author(s):  
Seetha Lakshmanan ◽  
Nicolas R. Thompson ◽  
Maeve Pascoe ◽  
Reena Mehra ◽  
Nancy Foldvary-Schaefer ◽  
...  
Keyword(s):  
Restless Legs Syndrome ◽  
Airway Pressure ◽  
Sleep Disordered Breathing ◽  
Positive Airway Pressure ◽  
Expected Improvement ◽  
Study Objective ◽  
Restless Legs ◽  
Irls Score ◽  
The Impact ◽  
Disordered Breathing

Study Objective: Studies have shown increased prevalence of restless legs syndrome (RLS) in sleep disordered breathing (SDB), however limited data have focused on the impact of SDB therapy on RLS. We hypothesize that positive airway pressure (PAP) will improve the International Restless Legs Syndrome (IRLS) score among SDB patients compared to patients without PAP. Methods: Patients with AHI ≥ 5 who responded positively to a RLS qualifier question from January 2010 to May 2015 were included in this retrospective study. IRLS score was used to measure RLS symptom severity. Two-sample t-tests and one-way analysis of variance were used to compare changes in IRLS score and linear regression models were created to examine IRLS change with PAP use and PAP adherence (PAP usage ≥4 h nightly for ≥70% of nights), adjusting for potential confounders. Results: In 434 patients (51.9 ± 13.4years, 50.5% female, 77.6% Caucasian; 325 PAP, 109 control), IRLS scores improved from baseline to follow-up, with the PAP group achieving significant improvement after adjustment for covariates (difference in IRLS: −1.8 (CI −3.6,0.00), p = 0.050). In self-reported PAP adherent patients, IRLS improvement was greater than controls (−5.3 ± 7.4 vs. −2.7 ± 7.6 respectively, p = 0.045), and comparable to non-adherent patients (−5.3 ± 7.4 vs. −3.0 ± 7.0, p = 0.091). Conclusions: Among SDB patients with a positive RLS qualifier, those who used PAP therapy achieved significantly greater improvement in IRLS scores than patients who did not use PAP, with more significant changes in the PAP adherent group. This is the first large clinical study to examine these relationships, providing a basis for future prospective interventional trials and informing clinicians of expected improvement in IRLS score in PAP treated SDB populations.

The effect of endovenous laser ablation on restless legs syndrome

2008 ◽  
Vol 23 (3) ◽  
pp. 112-117 ◽  
Author(s):  
C A Hayes ◽  
J R Kingsley ◽  
K R Hamby ◽  
J Carlow
Keyword(s):  
Laser Ablation ◽  
Restless Legs Syndrome ◽  
Rating Scale ◽  
Varicose Veins ◽  
Complete Relief ◽  
Venous Disease ◽  
Endovenous Laser Ablation ◽  
Restless Legs ◽  
Irls Score

Objectives Venous disease was proposed as a cause of restless legs syndrome (RLS) by Dr Karl A Ekbom in 1944, but has since remained largely unexplored. This study examines the effect of endovenous laser ablation (ELA) in patients with concurrent RLS and duplex-proven superficial venous insufficiency (SVI). Methods Thirty-five patients with moderate to very severe RLS (as defined by the 2003 National Institute of Health (NIH) RLS criteria) and duplex-proven SVI completed an international RLS rating scale questionnaire (IRLS) and underwent standard duplex examination to objectively measure the baseline severity of their conditions. They were separated into non-operative and operative cohorts. The operative cohort underwent ELA of refluxing superficial axial veins using the CoolTouch CTEV 1320 nm laser and ultrasound-guided sclerotherapy of the associated varicose veins with foamed sodium tetradecyl sulphate (STS). All patients then completed a follow-up IRLS questionnaire. Baseline and follow-up IRLS scores were compared. Results Operative correction of the SVI decreased the mean IRLS score by 21.4 points from 26.9 to 5.5, corresponding to an average of 80% improvement in symptoms. A total of 89% of patients enjoyed a decrease in their score of ≥15 points. Fifty-three percent of patients had a follow-up score of ≤5, indicating their symptoms had been largely alleviated and 31% had a follow-up score of zero, indicating a complete relief of RLS symptoms. Conclusions ELA of refluxing axial veins with the CTEV 1320 nm laser and foamed STS sclerotherapy of associated varicosities alleviates RLS symptoms in patients with SVI and moderate to very severe RLS. Recommendations SVI should be ruled-out in all patients with RLS before initiation or continuation of drug therapy.

scholarly journals Sex and the Risk of Restless Legs Syndrome in the General Population

2004 ◽  
Vol 164 (2) ◽  
pp. 196 ◽  
Author(s):  
Klaus Berger ◽  
Jan Luedemann ◽  
Claudia Trenkwalder ◽  
Ulrich John ◽  
Christof Kessler
Keyword(s):  
General Population ◽  
Restless Legs Syndrome ◽  
Restless Legs

Iron metabolism and the risk of Restless Legs Syndrome in an elderly general population - The MEMO-Study

2002 ◽  
Vol 249 (9) ◽  
pp. 1195-1199 ◽  
Author(s):  
Klaus Berger ◽  
Arnold von Eckardstein ◽  
Claudia Trenkwalder ◽  
Andreas Rothdach ◽  
Ralf Junker ◽  
...  
Keyword(s):  
General Population ◽  
Iron Metabolism ◽  
Restless Legs Syndrome ◽  
Restless Legs

Survival in Restless Legs Syndrome: An 11-Year Surveillance, Community-Based Population Study

2020 ◽  
Vol 54 (5) ◽  
pp. 375-382
Author(s):  
Esther Cubo ◽  
Carla Collazo Riobo ◽  
Cesar Gallego-Nieto ◽  
Miren Elizari-Roncal ◽  
Teresa Barroso-Pérez ◽  
...  
Keyword(s):  
Regression Analysis ◽  
General Population ◽  
Restless Legs Syndrome ◽  
Cox Regression ◽  
Cox Regression Analysis ◽  
Restless Legs ◽  
Risk Of Mortality ◽  
Increased Risk ◽  
Standardized Mortality Ratios

<b><i>Background:</i></b> A growing body of evidence relates restless legs syndrome (RLS) to an increased risk of mortality attributable to both cerebrovascular and cardiovascular events. The aim was to investigate survival in patients with RLS. <b><i>Methods:</i></b> This was an observational, retrospective longitudinal study of a cohort of patients followed up for 11 years. RLS was diagnosed by a physician using the International RLS Study Group criteria. Mortality was analyzed using age-standardized mortality ratios (SMR: observed/expected deaths) and Cox regression analysis. <b><i>Results:</i></b> Vital status was studied in a cohort of 232 patients: 181 women (78%), 96 with RLS (41.4%) with a mean age at baseline of 49.8 ± 15.0 years and a mean RLS duration of 14.1 ± 1.9 years, and 136 non-RLS (58.6%) with a mean age of 51.3 ± 14.9 years. This RLS cohort was followed up for a period of 10.4 ± 2.0 years. As of September 2019, 17 (7.3%) patients died (6 with RLS, 6.3%), and the most frequent cause was oncological (66.7%). A total of 944 person-years of observations were available for survival analysis. RLS was not associated with increased mortality in adjusted Cox regression analysis (HR = 1.12, 95% CI: 0.40–3.15), and survival was similar to that expected for the general population (SMR = 0.61, 95% CI: 0.27–1.36). <b><i>Conclusions:</i></b> RLS seems not to be associated with increased mortality compared to the general population. Still, studies with prospective data collection with large samples are needed to study the long-term mortality risk factors in RLS cohorts.

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