Effect of aripiprazole adjunctive to antidepressants on sexual functioning: A subgroup analysis of a 52-week open-label safety study (CN138–164)

IntroductionThis presentation addresses impacts of adjunctive aripiprazole (AA) in major depressive disorder (MDD).ObjectiveAssess impacts of long-term (≤52 weeks) open-label AA to ADT on efficacy, sexual function and weight change in MDD.MethodsData were analyzed post-hoc from de novo patients enrolled in an open-label safety study of AA after inadequate response to one or more ADT. Three ADT classes were included: SSRIs, SNRIs, and a noradrenaline-dopamine reuptake inhibitor, bupropion.Global well-being with AA was assessed (mean change in CGI-S score from baseline by ADT). Sexual functioning was assessed by Sexual Function Inventory (SFI) items: interest in sex, sexual arousal, achievement of orgasm, erection maintenance and sexual satisfaction. Item 6 captured change in the overall improvement score. Weight change at Week 52 (last observation carried forward) was assessed.ResultsOverall mean change in CGI-S (n = 285) by Week 52 was -1.5. Mean changes in CGI-S from baseline scores (4.2-4.4) were: escitalopram (n=64) -1.5, venlafaxine XL (n = 48) -1.4, sertraline (n = 39) -1.7, fluoxetine (n = 41) -1.3, paroxetine or CR (n = 37) -1.5 and bupropion XL or SR (n = 46) -1.4. Improvements on SFI items (n = 155) ranged from -0.2 (sexual satisfaction) to -0.6 (interest in sex and orgasm). Mean overall improvement score (3.8) indicated mild-to-moderate sexual dysfunction. All AA groups experienced a mean weight increase (range +1.8 kg [sertraline] to +3.3 kg [fluoxetine]).ConclusionsAA moderately improved CGI-S scores (to a similar degree) when added to three different classes of ADTs. Sexual functioning in patients on ADT modestly improved after adding aripiprazole to ADT.

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Sex Difference in Self-Reported Sexual Functioning Among Frail Older Adults

Innovation in Aging ◽

10.1093/geroni/igaa057.1002 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

pp. 313-313

Author(s):

Brianne Olivieri-Mui ◽

Sandra Shi ◽

Ellen McCarthy ◽

Dae Kim

Keyword(s):

Older Adults ◽

Logistic Regression ◽

Sex Differences ◽

Sexual Function ◽

Older Adult ◽

Sexual Functioning ◽

Social Life ◽

Well Being ◽

Adult Males ◽

Males And Females

Abstract Frailty may differentially impact how older adult males and females perceive sexual functioning, an important part of well-being. We assessed the level of frailty (robust, pre-frail, frail) for anyone with data on 11 sexual functioning questions asked in wave 2 of the National Social Life, Health, and Aging Project, 2010-2011 (n=2060). Questions covered five domains: overall sexual function (OSF), sexual function anxiety (SFA), changes in sexual function (CSF), erectile/vaginal dysfunction (EVD), and masturbation. Logistic regression identified sex differences in frailty and reporting worse sexual functioning. Linear regression predicted the number of domains reported as worse. Among males (n=1057), pre-frailty meant higher odds of reporting SFA (OR 1.8 95%CI 1.2-6.6), CSF (OR 1.7 95%CI 1.1-2.7), and EVD (OR 1.5 95%CI 1.0-2.2). Among females (n=1003), there was no difference in reporting by frailty. Females were more likely to report worse OSF (Robust: OR 7.4, 95%CI 4.8-11.4; Pre-frail: OR 6.2, 95%CI 3.9-9.9; Frail: OR 3.4 95%CI 1.7-6.6), but less likely to report SFA (Robust OR .3, 95%CI .2-.5; Pre-frail OR .2, 95%CI .1-.3; Frail OR .2 95%CI .1-.3). Pre-frail and frail females reported fewer domains as worse (Pre-frail coefficient -0.21 SE 0.09, Frail -0.43 SE 0.14). As frailty worsened, males reported more domains as worse (Pre-frail 0.24 SE 0.07, Frail 0.29 SE 0.08). Self-reported sexual functioning differs by sex at all levels of frailty, and reporting by males, but not females, changes with frailty. Providers should be aware that sexual functioning is of importance to both sexes despite varying degrees of frailty.

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Associations between sexual satisfaction and function and the severity of lower urinary tract symptoms among men in a rural sub-Saharan African community

Canadian Urological Association Journal ◽

10.5489/cuaj.5603 ◽

2019 ◽

Vol 13 (11) ◽

Author(s):

Andrew J. Macnab ◽

Lynn Stothers ◽

Jonathan Berkowitz ◽

Stacy Elliott ◽

Francis Bajunirwe

Keyword(s):

Urinary Tract ◽

Sexual Function ◽

Sexual Activity ◽

Lower Urinary Tract Symptoms ◽

Sexual Satisfaction ◽

Sexual Functioning ◽

Lower Urinary Tract ◽

Sexual Drive ◽

Urinary Tract Symptoms ◽

Lower Urinary

Introduction: The recognized association between erectile dysfunction (ED) with lower urinary tract symptoms (LUTS) from high-income countries is unreported from Africa. Authentic figures on prevalence of ED and LUTS from Africa are scarce in the literature. This study was conducted to quantify sexual function and satisfaction among Ugandan men in relation to LUTS severity. Methods: A convenience sample of men participating in a parallel, cross-sectional survey was used. The population, men >55 years living in Sheema district, Uganda, were recruited into two cohorts: those living in the community and those seeking clinic care due to bother from LUTS. This was to ensure inclusion of a full spectrum of LUTS. The instruments were the International Prostate Symptom Score (IPSS) to quantify LUTS and the Epstein Inventory (EI) to assess four measures of sexual functioning. Bivariate analysis compared community and clinic cohort participants, LUTS severity, and each sexual functioning item with two-sample t-tests for means and Chi-square tests of independence for categorical versions. Results: Participants included 415 men (238 community and 177 clinic) at mean age of 67.5 years vs. 62.9 (p<0.001) with mean IPSS of 9.32 vs. 17.07 (p≤0.001). Lower mean satisfaction with sexual activity and frequency of erections occurred in the clinic cohort (p≤0.001). Overall, all four questions assessing dissatisfaction with sexual function were significantly correlated with worsening LUTS; sexual satisfaction and frequency of sexual drive were also influenced by age and low levels of education. Conclusions: These are the first data describing the severity relationship between LUTS and ED in African men. Respondents reported dissatisfaction in the past year with the level of their sexual activity, frequency of sexual drive, ability to have erections, and sexual performance that related statistically to the severity of their LUTS.

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Pornography Use and Holistic Sexual Functioning: A Systematic Review of Recent Research

10.31234/osf.io/t8a4c ◽

2021 ◽

Author(s):

Camille Hoagland ◽

Joshua B. Grubbs

Keyword(s):

Systematic Review ◽

Sexual Satisfaction ◽

Sexual Behaviors ◽

Sexual Functioning ◽

Public Awareness ◽

Well Being ◽

Negative Effects ◽

Pornography Use ◽

Nuanced Understanding ◽

The Impact

Purpose of the Review: Pornography use is a common recreational activity in most developed nations with unrestricted internet access. As public awareness of pornography’s popularity has grown, so have concerns about potentially deleterious effects of pornography. One domain of particular concern has been the impact of pornography use and online sexual behaviors on sexual well-being. Over recent years, a number of studies have examined how pornography use relates to sexual well-being. The present work seeks to review such literature, with a particular focus on the effects of pornography on sexual functioning and sexual satisfaction. To this end, a systematic review of recent research (within the past 5 years) was conducted. Recent Findings: A total of 44 articles were included in the systematic review. In some situations, pornography use is associated with greater sexual functioning and greater sexual satisfaction, and in other cases it seems to be associated with lower sexual functioning and lower sexual satisfaction. Specifically, mere pornography use itself was most often not associated with sexual functioning in either direction, but self-reported problematic use of pornography was consistently associated with more sexual functioning problems. Summary: Collectively, results suggest a nuanced understanding of the effects of pornography on sexual well-being, with the context of and perceptions about pornography use being extremely important in predicting whether or not pornography has negative effects.

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Sexual satisfaction and sexual function in women with gynecologic cancer: validation of the Sexual Satisfaction Scale for Women in Taiwan

International Journal of Gynecological Cancer ◽

10.1136/ijgc-2018-000062 ◽

2019 ◽

Vol 29 (5) ◽

pp. 944-950

Author(s):

Jian Tao Lee ◽

Ya Lan Hu ◽

Helene H Lin ◽

Hsu-Min Tseng

Keyword(s):

Sexual Function ◽

Sexual Satisfaction ◽

Sexual Functioning ◽

Goodness Of Fit ◽

Gynecologic Cancer ◽

Chinese Version ◽

Female Sexual Function ◽

Satisfaction Scale ◽

Test Retest Reliability ◽

Fit Index

ObjectiveTo date, there are few validated multidimensional measures of sexual satisfaction that have been translated and empirically validated among Chinese speaking women with gynecologic cancer. The study was undertaken to validate the Sexual Satisfaction Scale for Women and to examine sexual satisfaction and sexual functioning in a sample of women with gynecologic cancer.MethodsA cross-sectional survey was conducted in 209 women, of which 106 had gynecologic cancer and 103 were in the non-cancer group with no history of cancer. Self-evaluations included the Female Sexual Function Index and Sexual Satisfaction Scale for Women Traditional Chinese version. Analyses for internal consistency, test–retest reliability, and construct validity were performed. Analysis of variance was conducted for group comparison on sexual satisfaction and sexual functioning.ResultsThe Sexual Satisfaction Scale for Women Traditional Chinese version showed good internal consistency reliability (Cronbach’s α=0.965) and acceptable test–retest reliability (r=0.954). The confirmatory factor analysis on the Sexual Satisfaction Scale for Women Traditional Chinese version suggested the goodness of fit indices (χ²/df, root mean square residual, goodness of fit index, normed-fit index, comparative fit index, and adjusted goodness of fit index) were good. The women with gynecologic cancer gave significantly lower ratings (mean 102.18) than those without cancer (mean 118.09) for each of the Sexual Satisfaction Scale for Women Traditional Chinese version domains and total score. Significant differences between women with cancer (mean 13.08) and without cancer (mean 22.92) were noted for each of the Female Sexual Function Index domains and total scores (all p<0.0001).ConclusionsThis translated version of the Sexual Satisfaction Scale for Women appears to be a reliable and valid instrument for measuring multifaceted components of sexual satisfaction in the general and clinical population of women rooted in Chinese culture.

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Effectiveness of Physical Therapy in Addressing Sexual Dysfunction in Individuals with Multiple Sclerosis: A Systematic Review and Meta-analysis

International Journal of MS Care ◽

10.7224/1537-2073.2020-039 ◽

2021 ◽

Author(s):

Arpita Gopal ◽

Rebecca Sydow ◽

Valerie Block ◽

Diane D. Allen

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Physical Therapy ◽

Sexual Dysfunction ◽

Sexual Function ◽

Pelvic Floor ◽

Sexual Satisfaction ◽

Well Being ◽

Current Evidence

Abstract Background: Individuals with multiple sclerosis (MS) frequently report sexual dysfunction, a condition that may result in low sexual satisfaction and decreased quality of life. Although sexual dysfunction is usually treated pharmacologically, physical therapists, especially those trained in pelvic floor physical therapy (PT), are well-equipped to address a variety of impairments that contribute to poor sexual function. The current evidence for effectiveness of PT interventions in improving sexual dysfunction, sexual satisfaction, and the emotional well-being aspect of quality of life was analyzed. Methods: The PubMed, CINAHL, and PEDro databases were searched through December 2019. Articles were included if participants had a clinical diagnosis of MS, reported sexual dysfunction or pain with intercourse, and had an intervention within the PT scope that addressed sexual dysfunction. Means and SDs were extracted from each study independently by two authors. Effect sizes (d) and 95% CIs were calculated within and across studies. Results: Eight studies met the inclusion criteria. Combined effects were significant and large across six studies for sexual function (d = 0.82, 95% CI, 0.57–1.06), moderate across seven studies for sexual satisfaction (d = 0.65, 95% CI, 0.43–0.87), and moderately large across two studies for emotional well-being (d = 0.78, 95% CI, 0.17–1.40). Between-group differences reached significance for sexual satisfaction (d = 0.29, 95% CI, 0.03–0.55). Conclusions: Sexual function, sexual satisfaction, and emotional well-being can all be effectively addressed with various PT interventions. Highly effective interventions included pelvic floor muscle training and mindfulness. Future research should compare PT interventions with non-PT controls to determine best practice in this population.

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