P.3.043 Comparative effects of atypical antipsychotic on tardive dyskinesia and neurocognition: a 24-week randomized, single-blind, controlled study

BackgroundIn recent years there has been a shift to ‘community care’ and the introduction of several ‘atypical’ antipsychotic drugs. We report the impact of these changes.MethodIn Nithsdale, Dumfries and Galloway, Scotland, the population of patients with schizophrenia was identified in 1996. This census replicated a study carried out in 1981. The population with schizophrenia were compared on clinical and social variables. The whereabouts in 1996 of the 1981 population was determined.ResultsIn comparison with the 1981 population, more patients in 1996 had positive, negative and non-schizophrenic symptoms. More showed tardive dyskinesia. Social adjustment had not changed. They had spent less time in hospital; fewer (13%) were living with their parents; and fewer (8%) were employed. By 1996, 35% of the 1981 cohort had died (standardised mortality rate male – 154, female – 162).ConclusionsThe mental health of a community of people with schizophrenia living in a rural area in 1996 was poorer than in 1981.

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Effects of Kinesio Taping on pain, paresthesia, functional status, and overall health status in patients with symptomatic thoracic outlet syndrome: A single-blind, randomized, placebo-controlled study

Acta Orthopaedica et Traumatologica Turcica ◽

10.5152/j.aott.2020.19042 ◽

2020 ◽

Vol 54 (4) ◽

pp. 394-401

Author(s):

Emine Aygul Ortac ◽

◽

Tunay Sarpel ◽

Ilke Coskun Benlidayi ◽

◽

...

Keyword(s):

Health Status ◽

Functional Status ◽

Thoracic Outlet Syndrome ◽

Controlled Study ◽

Kinesio Taping ◽

Single Blind ◽

Overall Health Status

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Evaluation of Genotoxicity and Efficacy of At-home Bleaching in Smokers: A Single-blind Controlled Clinical Trial

Operative Dentistry ◽

10.2341/14-121-c ◽

2015 ◽

Vol 40 (2) ◽

pp. E47-E55 ◽

Cited By ~ 15

Author(s):

JL de Geus ◽

M Rezende ◽

LS Margraf ◽

MC Bortoluzzi ◽

E Fernández ◽

...

Keyword(s):

Repeated Measures ◽

Smoking Habit ◽

Gingival Tissue ◽

Controlled Study ◽

Control Group ◽

Controlled Clinical Trial ◽

Shade Guide ◽

Experimental Group ◽

Single Blind ◽

At Home

SUMMARY Objective This single-blind controlled study evaluated the genotoxicity and efficacy of at-home bleaching in smokers and nonsmokers. Methods We selected 60 patients with central incisors A2 or darker: 30 smokers (experimental group) and 30 nonsmokers (control group). The bleaching was carried out with 10% carbamide peroxide for three hours a day for three weeks. The color was evaluated using a shade guide, Vita Bleachedguide 3D-Master, at baseline, during bleaching (first, second, and third weeks), and one week and one month after bleaching. Smears were obtained with a moistened wooden spatula from marginal gingiva. All the cytologic smears were stained with Giemsa solution. From each slide, 1000 cells were examined under 40× magnification and where micronuclei (MN) were located, they were examined under 100× magnification. The change in shade guide units at the different assessment periods and the frequency of MN were subjected to a two-way repeated measures analysis of variance and Tukey test (α=0.05). Results In both groups we detected a whitening of approximately 4 to 5 shade guide units, without color rebound after one month (p>0.05). The frequency of MN was significantly higher in the experimental group than in the control group, regardless of the bleaching treatment (p>0.001). Conclusion The efficacy of bleaching does not appear to be affected by the smoking habit. Additionally, at-home bleaching did not induce DNA damage to the gingival tissue during the bleaching period.

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