Aloe vera extract 0.5% in hydrophilic cream versus Aloe vera gel for the management of genital herpes in males. A placebo-controlled, double-blind, comparative study

Objective: To compared efficacy of alpha lipoic acid (antioxidant medication) and aloe vera gel together versus intralesional steroids (hydrocortisone) in management of oral submucous fibrosis by evaluating post treatment clinical features of mouth opening and burning sensation. Study Design: A prospective comparative study. Place and Duration of Study: Department of ENT, Combined Military Hospital, Malir Karachi, from Jul 2018 to Mar 2020. Methodology: Twenty-eight patients were involved in the research and were distributed into two groups, I and II. Alpha lipoid acid with aloe vera gel was given in group I and hydrocortisone was given in group II. Burning sensation and mouth opening were recorded both at start and at monthly interval later on for three consecutive months. The data collected were statistically analyzed by using SPSS-22. Results: A significant lessening in burning sensation (p<0.001) and improvement in mouth opening were noticed in both groups. However, comparison between alpha lipoic acid with aloe vera gel group versus hydrocortisone group showed almost similar results. Conclusion: Alpha lipoic acid and aloe vera gel can significantly improve oral submucous fibrosis clinically. So, these can be utilized as an alternative option in cases where intralesional steroid is poorly tolerated or is contraindicated.

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Comparative Study of the Possible Hepatoprotective Effect of Each of N-acetylcysteine, Coenzyme Q10 and Aloe Vera Gel in Acute Acetaminophen Induced Hepatotoxicity in Albino Rats. (Histological and Biochemical Study)

Ain Shams Journal of Forensic Medicine and Clinical Toxicology ◽

10.21608/ajfm.2014.18680 ◽

2014 ◽

Vol 23 (2) ◽

pp. 115-138

Author(s):

Hoda Abd El Salam ◽

Haidy Megahed ◽

Saffa Abd El Aziz ◽

Mona Sobhy ◽

Hala Abd El-Mouaty

Keyword(s):

Comparative Study ◽

Coenzyme Q10 ◽

Biochemical Study ◽

Aloe Vera ◽

Hepatoprotective Effect ◽

Albino Rats ◽

Aloe Vera Gel

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Human Leukocyte Interferon-α in a Hydrophilic Creamversusin a Gel for the Treatment of Genital Herpes in Males: A Placebo-Controlled, Double-Blind, Comparative Study

The Journal of Dermatology ◽

10.1111/j.1346-8138.1997.tb02293.x ◽

1997 ◽

Vol 24 (9) ◽

pp. 564-568 ◽

Cited By ~ 8

Author(s):

Tanweer A. Syed ◽

Oliver Abbas Ahmadpour ◽

Seyed Ali Ahmad ◽

Seyed Hamzeh Ahmad

Keyword(s):

Comparative Study ◽

Genital Herpes ◽

Human Leukocyte ◽

Interferon Α ◽

Double Blind ◽

Human Leukocyte Interferon

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A double blind study to compare the efficacy of Aloe vera gel and undecylenoyl phenylalanine 2% for treatment of melisma.

The Professional Medical Journal ◽

10.29309/tpmj/2020.27.08.4459 ◽

2020 ◽

Vol 27 (08) ◽

pp. 1770-1776

Author(s):

Farwa Naqvi ◽

Zaib ◽

Iram Imran ◽

Ahmed Amin Khan Faraz ◽

Tahira Tabussam ◽

...

Keyword(s):

Controlled Trial ◽

Aloe Vera ◽

P Value ◽

Double Blind Study ◽

Double Blind ◽

Dermatology Department ◽

Medical College ◽

Aloe Vera Gel ◽

One Way Anova

Objectives: To compare the efficacy of Aloe vera and undecylenoyl phenylalanine 2% for Melasma treatment. Study Design: Double Blind Randomized Controlled Trial. Setting: OPD Dermatology Department of DHQ Teaching Hospital, Sargodha Medical College, Sargodha. Period: October 2018 to March 2019. Material & Method: There were total 120 patients (both male and female) having 60 patients in each group. Patients with melasma were at random allocated either Aloe vera leaf gel and undecylenoyl phenylalanine 2% at night for 12 weeks. Aloe vera leaf gel and undecylenoyl phenylalanine 2% were packed in indistinguishable similar tubes numbered 1 and 2 respectively. Neither the investigators who calculated MASI score nor the patients was aware which tube carry Aloe vera leaf gel or undecylenoyl phenylalanine 2%. The patients were advised to revisit after every 4 weeks for follow-up for three months. Results: On comparison, the mean of Modified MASI score with treatment with Aloe vera leaf gel was reduced from 17.81 to 17.36. One way ANOVA was applied to compare improvement of modified MASI score at 0, 4, 8 and 12 weeks by applying Aloe vera leaf gel which was insignificant with p-value of 0.535. Mean of Modified MASI score with treatment with undecylenoyl phenylalanine 2% was reduced from 18.13 to 4.95. One way ANOVA was quite significant with undecylenoyl phenylalanine 2% with p-value of ˂ 0.001. Conclusion: Undecylenoyl phenylalanine may represent an efficious and beneficial therapy of melasma. Herbal agents which contain Aloe vera and falsely claim that they are effective should be discouraged to treat melasma.

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