Adsorption behaviour and conformation of selected poly(ethylene oxide) copolymers on the surface of a model colloidal drug carrier

1997 ◽  
Vol 122 (1-3) ◽  
pp. 151-159 ◽  
Author(s):  
S. Stolnik ◽  
N.C. Felumb ◽  
C.R. Heald ◽  
M.C. Garnett ◽  
L. Illum ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Drug Carrier ◽  
Adsorption Behaviour ◽  
Colloidal Drug Carrier ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

scholarly journals γ‐Butyrolactone Copolymerization with the Well‐Documented Polymer Drug Carrier Poly(ethylene oxide)‐ block ‐poly(ε‐caprolactone) to Fine‐Tune Its Biorelevant Properties

2020 ◽  
Vol 20 (5) ◽  
pp. 2070009
Author(s):  
Tomáš Urbánek ◽  
Jiří Trousil ◽  
Dmytro Rak ◽  
Kristýna Gunár ◽  
Rafał Konefał ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Drug Carrier ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene ◽  
Fine Tune

γ‐Butyrolactone Copolymerization with the Well‐Documented Polymer Drug Carrier Poly(ethylene oxide)‐ block ‐poly(ε‐caprolactone) to Fine‐Tune Its Biorelevant Properties

2020 ◽  
Vol 20 (5) ◽  
pp. 1900408 ◽  
Author(s):  
Tomáš Urbánek ◽  
Jiří Trousil ◽  
Dmytro Rak ◽  
Kristýna Gunár ◽  
Rafał Konefał ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Drug Carrier ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene ◽  
Fine Tune

Drug-Eluting Coronary Stents Coated with Polysulfone-Poly(ethylene Oxide) Block Copolymer by Ultrasonic Spray

2008 ◽  
Vol 373-374 ◽  
pp. 633-636 ◽  
Author(s):  
Xing Zhong Gu ◽  
Hong Yi ◽  
Zhong Hua Ni ◽  
Jian Hua Fang
Keyword(s):  
Drug Release ◽  
Ethylene Oxide ◽  
Release Rate ◽  
Drug Carrier ◽  
Optimal Operation ◽  
Drug Release Rate ◽  
Ultrasonic Spray ◽  
Drug Eluting ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Amphiphilic polysulfone-poly(ethylene oxide) block copolymers (PSF-b-PEOs) with different contents of PEO, have been successfully synthesized and employed as the drug carrier for use in drug-eluting stent (DES) systems. They are well soluble in organic solvents such as tetrahydrofuran (THF). Cell growth, hemolysis, cell hyperplasia, toxicity and sensitization tests revealed that PSF-b-PEOs have good biocompatibility. Silolimus was selected as the drug and the loading level was controlled at 10 or 20 wt%. PSF-b-PEO-coated stents were fabricated by the widely used ultrasonic spray coating technique. Pre- and post-expansion morphologies of the coatings were observed by optical microscopy (OM) and scanning electron microscopy (SEM). Under the optimal operation conditions, the stents have uniform and smooth coating surface. No cracks or peels were observed when the coating stents were expanded. No drug particles were observed on the stent surface. PEO content in PSF-b-PEOs greatly influences drug release rate, and the higher the PEO content, the faster the release rate. PSF-b-PEO film comprising 30% PEO displayed relatively reasonable drug release rate, i.e., about 80% silolimus were released from the film after release tests in phosphate buffer solutions (PH = 7.4) containing 10 v% ethanol at 37 °C for 24 days.

The Structure of Radiation Cross-Linked Poly (ethylene oxide) Gels

1971 ◽  
Vol 29 ◽  
pp. 76-77
Author(s):  
C. E. Cluthe ◽  
G. G. Cocks
Keyword(s):  
Molecular Weight ◽  
Ethylene Oxide ◽  
Parallel Plate ◽  
Average Molecular Weight ◽  
Radical Reaction ◽  
Free Radical Reaction ◽  
Nitrogen Gas ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene ◽  
Initial Viscosity

Aqueous solutions of a 1 weight-per cent poly (ethylene oxide) (PEO) were degassed under vacuum, transferred to a parallel plate viscometer under a nitrogen gas blanket, and exposed to Co60 gamma radiation. The Co60 source was rated at 4000 curies, and the dose ratewas 3.8x105 rads/hr. The poly (ethylene oxide) employed in the irradiations had an initial viscosity average molecular weight of 2.1 x 106.The solutions were gelled by a free radical reaction with dosages ranging from 5x104 rads to 4.8x106 rads.

Preparation of Organized Mesoporous Silica from Sodium Metasilicate Solutions in Alkaline Medium Using Nonionic Surfactants

2003 ◽  
Vol 68 (10) ◽  
pp. 2019-2031 ◽  
Author(s):  
Markéta Zukalová ◽  
Jiří Rathouský ◽  
Arnošt Zukal
Keyword(s):  
Mesoporous Silica ◽  
Ethylene Oxide ◽  
Sodium Metasilicate ◽  
Spherical Particles ◽  
Structure Directing Agent ◽  
Inorganic Species ◽  
Poly Ethylene Oxide ◽  
Acidic Conditions ◽  
Poly Ethylene ◽  
Hydrolysis Of

A new procedure has been developed, which is based on homogeneous precipitation of organized mesoporous silica from an aqueous solution of sodium metasilicate and a nonionic poly(ethylene oxide) surfactant serving as a structure-directing agent. The decrease in pH, which induces the polycondensation of silica, is achieved by hydrolysis of ethyl acetate. Owing to the complexation of Na+ cations by poly(ethylene oxide) segments, assembling of the mesostructure appears to occur under electrostatic control by the S0Na+I- pathway, where S0 and I- are surfactant and inorganic species, respectively. As the complexation of Na+ cations causes extended conformation of poly(ethylene oxide) segments, the pore size and pore volume of organized mesoporous silica increase in comparison with materials prepared under neutral or acidic conditions. The assembling of particles can be fully separated from their solidification, which results in the formation of highly regular spherical particles of mesoporous silica.

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