Polymerized ion pair amphiphile that shows remarkable enhancement in encapsulation efficiency and very slow release of fluorescent markers

In recent years, the risk of ovarian cancer (OC) has become increasingly prevalent. Gemcitabine (GE) provides excellent inhibitory action on some solid tumors, but how it affects OC remains elusive. In the present research, we prepared GE nanoparticles (GEN) and analyzed OC cell viability under its intervention, hoping to conceive novel ideas for future clinical treatment of OC. Through experiments, we observed that the encapsulation efficiency and drug loading of GEN were observably higher than those of GE alone, and the release rate presented a stable slow release state. Under GEN intervention, the viability of OC cells was decreased, the apoptosis rate was elevated, and the apoptosis-related proteins were activated, while CA-125 was suppressed. Therefore, we can see that GEN exert favorable inhibitory action on OC cell viability, whose mechanism may be achieved through activating apoptosis-related proteins and inhibiting CA-125, which may be a new scheme for OC treatment in the future.

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Use of ion pair amphiphile as an alternative of natural phospholipids in enhancing the stability and anticancer activity of oleanolic acid loaded nanostructured lipid carriers

Colloids and Surfaces A Physicochemical and Engineering Aspects ◽

10.1016/j.colsurfa.2018.02.039 ◽

2018 ◽

Vol 545 ◽

pp. 147-156 ◽

Cited By ~ 1

Author(s):

Gourab Karmakar ◽

Prasant Nahak ◽

Biplab Roy ◽

Pritam Guha ◽

Koji Tsuchiya ◽

...

Keyword(s):

Anticancer Activity ◽

Oleanolic Acid ◽

Ion Pair ◽

Nanostructured Lipid Carriers ◽

The Stability ◽

Ion Pair Amphiphile

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Molecular Dynamics Study of Catanionic Bilayers Composed of Ion Pair Amphiphile with Double-Tailed Cationic Surfactant

Langmuir ◽

10.1021/la300651u ◽

2012 ◽

Vol 28 (21) ◽

pp. 8156-8164 ◽

Cited By ~ 19

Author(s):

An-Tsung Kuo ◽

Chien-Hsiang Chang ◽

Wataru Shinoda

Keyword(s):

Molecular Dynamics ◽

Cationic Surfactant ◽

Ion Pair ◽

Ion Pair Amphiphile

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Interplay between alkyl chain asymmetry and cholesterol addition in the rigid ion pair amphiphile bilayer systems

The Journal of Chemical Physics ◽

10.1063/1.4974089 ◽

2017 ◽

Vol 146 (3) ◽

pp. 035102 ◽

Cited By ~ 5

Author(s):

Fong-yin Huang ◽

Chi-cheng Chiu

Keyword(s):

Alkyl Chain ◽

Ion Pair ◽

Ion Pair Amphiphile

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Nano-Aromatic Drugs Based on Mesoporous Silica Nanoparticles and Bergamot Essential Oil for Anti-Depression

Journal of Biomedical Nanotechnology ◽

10.1166/jbn.2021.3100 ◽

2021 ◽

Vol 17 (6) ◽

pp. 1242-1248

Author(s):

Xiao-Hong Yang ◽

Huan Peng ◽

Qiu-Lian Hao ◽

Jian-Ze Wang ◽

Zhi-Guo Lu ◽

...

Keyword(s):

Essential Oil ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Encapsulation Efficiency ◽

Evaporation Rate ◽

Slow Release ◽

Mesoporous Silica Nanoparticles ◽

Pathological Feature ◽

Low Mood ◽

Pore Properties

Depression is a mental disorder characterized by low mood as the main pathological feature. Current medications for depression have long treatment cycles and serious side effects. Aromatherapy can alleviate depression in a “moistening things silently” way, but the fast evaporation rate of aromatic drugs weakens the effect of aromatherapy. In this study, we designed and prepared nano-aromatic drugs with slow release for anti-depressant application. We first synthesized rod-shaped mesoporous silica nanoparticles (MSNs) and encapsulated bergamot essential oil. These nanoaromatic drugs were named BEO@MSNs. Subsequently, we analyzed the pore properties of MSNs and BEO@MSNs. Further, we explored the thermal stability, encapsulation efficiency, and slow-release properties of bergamot essential oil in BEO@MSNs. Finally, we used BEO@MSNs to alleviate depression in mice while constructing depression model mice via corticosterone. The results showed that BEO@MSNs had excellent anti-depressant effects and biosafety

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