Addition of hydrogen bond donating excipients to oil solution: effect on in vitro drug release rate and viscosity

Five ordered mesoporous materials, SBA-1, MCM-48, SBA-7, MCM-41 and SBA-15, were prepared and tested as mesophase drug delivery systems with an anti-inflammatory drug, ibuprofen. The results of these mesostructures on in vitro ibuprofen delivery indicated that the mesoporous materials with cage-like structure, SBA-1 and SBA-7, had unfavorable load and release properties. MCM-48 also showed fast release rate due to its opening channel. However, the hexagonal mesostructure in MCM-41 and SAB-15 was advantageous for extending drug release rate although a little difference existed between them. Compared with commercial ibuprofen capsule, the release system based on MCM-41 materials displayed the drug efficacy in a longer time.

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Development of Acrylic Matrix Type Ketoprofen Patch

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.506.533 ◽

2012 ◽

Vol 506 ◽

pp. 533-536

Author(s):

Nanthida Wonglertnirant ◽

S. Tipwichai ◽

Praneet Opanasopit ◽

Theerasak Rojanarata ◽

Suwannee Panomsuk ◽

...

Keyword(s):

Drug Release ◽

Release Rate ◽

Pressure Sensitive Adhesive ◽

Drug Release Rate ◽

Matrix Type ◽

Adhesive Matrix ◽

Pressure Sensitive ◽

Transdermal Patches ◽

Significant Difference

Ketoprofen transdermal patches (KTPs) were fabricated using an acrylic pressure sensitive adhesive (PSA) polymer. The influence of different factors (amount of PSA, drug content, and pressure applying on the backing membrane during preparation) on the characteristics of ketoprofen patch (thickness, W/A ratio, and adhesiveness of matrix film) and in vitro drug release behavior were investigated. The results revealed the successful fabrication and a good physical appearance of KTPs using acrylic PSA. Microscopic observations, FTIR spectra, and DSC thermograms were permitted to demonstrate that the drug was dispersed molecularly in the polymer. As the amount of PSA in the adhesive matrix was increased, the release rate of ketoprofen was decreased. Contrarily, the drug release rate was increased corresponding to the increase of ketoprofen content in the adhesive matrix. There was no significant difference in the release rate when the pressure applying on the backing membrane was varied. The kinetic of ketoprofen release from acrylic matrix type transdermal patches followed the Higuchis diffusion model.

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Influence of Vertical Diffusion Cell Set-Up on In Vitro Silver Sulfadiazine Drug Release from Thermo-Responsive Cellulose Hydrogel

Materials Science Forum ◽

10.4028/www.scientific.net/msf.1030.19 ◽

2021 ◽

Vol 1030 ◽

pp. 19-26

Author(s):

Maha Mohammad Al-Rajabi ◽

Teow Yeit Haan

Keyword(s):

Drug Release ◽

Release Rate ◽

Silver Sulfadiazine ◽

Diffusion Cell ◽

Vertical Diffusion ◽

In Vitro Drug Release ◽

Cellulose Hydrogel ◽

Membrane Type ◽

Set Up

In-vitro drug release is used to measure the release of the silver sulfadiazine (SSD) from thermo-responsive cellulose hydrogel using a vertical diffusion cell (VDC). However, selected VDC set-up used by researchers are random, and the studies are lacking in information on the challenging sink conditions during in-vitro drug release study. The objective of this study is to examine the influence of VDC set-up on the in-vitro SSD drug release from thermo-responsive cellulose hydrogel. VDC set-up including receptor medium composition, membrane type, and stirring speed were studied. The results depicted that SSD release rate increased with increasing ammonia percentage in phosphate buffer solution. On the other hand, membrane type do not influence SSD release rate. While, increasing stirring speed results in forming vortex or air bubble entrapment underneath the membrane. 0.25 v/v% ammonia receptor medium, cellulose membrane or polysulfone membrane, and 600 rpm stirring speed are the optimum VDC set-up, confirming sink condition and discriminating ability of this optimum VDC set-up. This work has successfully studied the influence of VDC set-up on in-vitro SSD drug release from thermo-responsive cellulose hydrogel, and the optimum VDC set-up was selected.

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Phase Inversion Dynamics of PLGA Solutions Related to Drug Delivery

MRS Proceedings ◽

10.1557/proc-550-41 ◽

1998 ◽

Vol 550 ◽

Author(s):

A.J. Mchugh ◽

P.D. Graham ◽

K.J. Brodbeck

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Release Rate ◽

Phase Inversion ◽

In Vitro Drug Release ◽

Water Influx ◽

Initial Release ◽

Dark Ground ◽

Initial Drug

AbstractDark ground optical microscopy, electron microscopy, and protein release rate studies have been used to quantify the effects of formulation changes on the phase inversion dynamics and in vitro drug release properties of an injectable PLGA-based drug delivery system. Gel growth rates and water influx rates are determined from plots of the square of the respective front with time. Results show that additives that increase the solution gelation rate and produce finger-like void morphologies result in higher initial release rates. Conversely, additives that slow the rate of gelation dramatically reduce the initial drug release rate and lead to a more dense sponge-like morphology.

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Drug release rate in vitro and bioavailability of new controlled release suspension of spherical matrix of ibuprofen.

Drug Delivery System ◽

10.2745/dds.4.100 ◽

1989 ◽

Vol 4 (2) ◽

pp. 100-104

Author(s):

Yoshiaki Kawashima ◽

Taro Iwamoto ◽

Toshiyuki Niwa ◽

Hirofumi Takeuchi ◽

Tomoaki Hino ◽

...

Keyword(s):

Controlled Release ◽

Drug Release ◽

Release Rate ◽

Drug Release Rate

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A Correlative Model to Predict In Vivo AUC for Nanosystem Drug Delivery with Release Rate-Limited Absorption

Journal of Pharmacy & Pharmaceutical Sciences ◽

10.18433/j3np5n ◽

2012 ◽

Vol 15 (4) ◽

pp. 583 ◽

Cited By ~ 2

Author(s):

Mohammad Barzegar-Jalali ◽

Kaivan Mohammadi ◽

Ghobad Mohammadi ◽

Hadi Valizadeh ◽

Azim Barzegar-Jalali ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Release Rate ◽

Biological Action ◽

Theoretical Justification ◽

In Vitro Drug Release ◽

Proposed Model ◽

Gaining Insight

Purpose. Drug release from nanosystems at the sites of either absorption or effect biophase is a major determinant of its biological action. Thus, in vitro drug release is of paramount importance in gaining insight for the systems performance in vivo. Methods. A novel in vitro in vivo correlation, IVIVC, model denoted as double reciprocal area method was presented and applied to 19 drugs from 55 nano formulations with total 336 data, gathered from literature. Results. The proposed model correlated the in vitro with in vivo parameters with overall error of 12.4 ± 3.9%. Also the trained version of the model predicted the test formulations with overall error of 15.8 ± 3.7% indicating the suitability of the approach. A theoretical justification was provided for the model considering the unified classical release laws. Conclusion. The model does not necessitate bolus intravenous drug data and seems to be suitable for IVIVC of drugs with release rate-limited absorption. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

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