The present study compares the buffeting response of a suspension bridge computed in the time-domain with full-scale measurement data. The in-service Lysefjord Bridge is used as a study case, which allows a unique comparison of the computational results with full-scale buffeting bridge response observed during a one year monitoring period. The time-domain analysis is performed using a finite element approach. Turbulent wind field is simulated according to the governing bridge design standard in Norway for three different terrain categories. The time-domain analysis indicates that the non-linear components of the wind loading are of limited importance in the present case, contributing by less than 5% to the standard deviation of the lateral displacement. The contribution of the buffeting loads on the main cables, hangers and towers to the lateral dynamic response of the bridge girder is about 6%. With the time-domain method, mode coupling as well as the influence of cables and towers are well captured in the simulation results. The buffeting response, estimated in terms of the standard deviation of acceleration, is found to be in good agreement with the field measurement data. Comparison suggests that the proposed numerical method, with the non-linear force model, is able to predict the bridge response reasonably well.