CLINICAL SIGNIFICANCE OF DEAMIDATED GLIADIN PEPTIDE ANTIBODIES IN PATIENTS WITH CHRONIC LIVER DISEASES

2011 ◽  
Vol 22 ◽  
pp. S34
Author(s):  
Nikolaos K. Gatselis ◽  
Kalliopi Zachou ◽  
George Tzelas ◽  
Stella Gabeta ◽  
George K. Koukoulis ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Gliadin Peptide ◽  
Peptide Antibodies

scholarly journals The clinical significance of serum chitinase 3‐like 1 in hepatitis B–related chronic liver diseases

2020 ◽  
Vol 34 (5) ◽  
Author(s):  
Zhenluo Jiang ◽  
Shuwei Wang ◽  
Jiancheng Jin ◽  
Sheng Ying ◽  
Zhigang Chen ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Clinical Significance ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Diseases

scholarly journals Prevalence and Clinical Significance of Immunoglobulin A Antibodies against Tissue Transglutaminase in Patients with Diverse Chronic Liver Diseases

2005 ◽  
Vol 12 (8) ◽  
pp. 941-948 ◽  
Author(s):  
Anastasios E. Germenis ◽  
Efthalia E. Yiannaki ◽  
Kalliopi Zachou ◽  
Violeta Roka ◽  
Sotirios Barbanis ◽  
...  
Keyword(s):  
Liver Disease ◽  
Clinical Significance ◽  
Liver Diseases ◽  
Tissue Transglutaminase ◽  
Immunoglobulin A ◽  
Chronic Liver ◽  
Intestinal Biopsy ◽  
Enzyme Linked Immunosorbent Assay ◽  
Chronic Liver Diseases ◽  
Hla Dq

ABSTRACT The prevalence of celiac disease (CD) and the prevalence and clinical significance of anti-tissue transglutaminase (tTG) antibodies (tTGAbs) in a large series of patients with chronic liver diseases were assessed. We studied 738 patients (462 with chronic viral hepatitis, 117 with autoimmune liver diseases, 113 with alcoholic or nonalcoholic fatty liver disease, and 46 with other liver disorders) and 1,350 healthy controls (HC). Immunoglobulin A (IgA) tTGAbs were measured by enzyme-linked immunosorbent assay and a microsphere-based flow cytometric assay. Positive sera were investigated for IgA antiendomysial antibodies (EmA). IgA tTGAb-positive subjects were invited to undergo a small-intestinal biopsy and HLA-DQ allele typing. Four of 1,350 HC (0.3%) tested tTGAb+ EmA+ and underwent a biopsy (CD confirmation in all). Four of 738 liver disease patients tested tTGAbs+ EmA+ (0.54%; not statistically significant). Two were HCV infected (1.24%; not statistically significant), and two had transaminasemia of unknown origin. Forty-three patients tested tTGAbs+ EmA− (5.8%; P < 0.001 compared to HC). Inhibition experiments verified the existence of specific IgA anti-tTG reactivity. Twenty-six of 43 patients underwent a biopsy (all negative for CD). Binary logistic regression analysis revealed age (P = 0.008), cirrhosis (P = 0.004), alkaline phosphatase (P = 0.026), and antinuclear antibodies (P = 0.012) as independent risk factors for tTGAb reactivity among the patients. It was concluded that CD prevalence is the same in HC and patients with chronic liver diseases. The prevalence of tTGAbs is higher in hepatic patients compared to HC, but their specificity for CD diagnosis in this group of patients is low. tTGAbs in patients appear to be associated with the presence of autoimmunity, cirrhosis, and cholestasis, irrespective of the origin of the liver disease.

scholarly journals Direct-acting antiviral agent-resistant mutants in patients with type C chronic liver diseases: Detection and its clinical significance

Kanzo ◽  
2015 ◽  
Vol 56 (11) ◽  
pp. 621-624 ◽  
Author(s):  
Tatsuya Aikawa ◽  
Chisato Ueno ◽  
Yohko Kikuchi ◽  
Fumio Tsuda ◽  
Hiroshi Ohnishi ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Liver Diseases ◽  
Antiviral Agent ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Direct Acting Antiviral ◽  
Type C ◽  
Resistant Mutants ◽  
Direct Acting

scholarly journals Serum angiotensin converting enzyme(ACE) activity in various chronic liver diseases and its clinical significance.

Kanzo ◽  
1987 ◽  
Vol 28 (9) ◽  
pp. 1267-1268
Author(s):  
Masato MIYAGAWA ◽  
Shiro MAEYAMA ◽  
Hideki YOSHIDA ◽  
Makoto KOHNO ◽  
Kazuhiko OKABE ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Clinical Significance ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Converting Enzyme ◽  
Chronic Liver Diseases ◽  
Serum Angiotensin Converting Enzyme ◽  
Ace Activity
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