178 Wnt5b promotes the cell invasion and migration essential to the metastasis of oral squamous cell carcinoma cell through activation of Cdc42 and RhoA

2015 ◽  
Vol 51 ◽  
pp. S22
Author(s):  
S. Iwai ◽  
A. Takeshita ◽  
S. Kishimoto ◽  
Y. Morita ◽  
A. Niki-Yonekawa ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Invasion ◽  
Carcinoma Cell ◽  
Squamous Cell Carcinoma Cell ◽  
Invasion And Migration ◽  
And Migration

scholarly journals LncRNA NCK1-AS1 in plasma distinguishes oral ulcer from early-stage oral squamous cell carcinoma

2020 ◽  
Vol 27 (1) ◽  
Author(s):  
Fei Le ◽  
Yangqian Ou ◽  
Ping Luo ◽  
Xiaoming Zhong
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Invasion ◽  
Early Stage ◽  
Oral Ulcer ◽  
Jiangxi Province ◽  
Invasion And Migration ◽  
And Migration

Abstract Background Oral squamous cell carcinoma (OSCC) at early stages can be misdiagnosed as an oral ulcer (OU) due to similar symptoms, such as chronic and indurated ulcer. LncRNA NCK1-AS1 has been characterized as a key player in cervical cancer, while its role in OSCC is unknown. Methods All participants were selected at Jiangxi Province Tumor Hospital from December 2016 to December 2018. Expression levels of NCK1-AS1 and miR-100 in plasma from both OSCC and OU patients were measured by RT-qPCR. Diagnostic analysis was performed through ROC curve. Potential interactions between NCK1-AS1 and miR-100 were detected by cell transfection experiments. Cell invasion and migration were assessed by Transwell assays. Results The expression of NCK1-AS1 was upregulated in early-stage OSCC patients but not in OU patients. Upregulation of NCK1-AS1 distinguished OSCC patients from OU patients. The expression of miR-100 was inversely correlated with the expression of NCK1-AS1. Overexpression of NCK1-AS1 was followed by promoted OSCC cell invasion and migration. Overexpression of miR-100 did not affect the expression of NCK1-AS1 but inhibited the role of NCK1-AS1. Conclusions Therefore, NCK1-AS1 may promote the metastasis of OSCC by downregulating miR-100.

scholarly journals High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma

2017 ◽  
Vol 13 (6) ◽  
pp. 4017-4026 ◽  
Author(s):  
Da Ma ◽  
Juan Fang ◽  
Ying Liu ◽  
Jing-Jing Song ◽  
Yan-Qiong Wang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cancer Cell ◽  
Squamous Cell ◽  
Cell Invasion ◽  
Cancer Cell Invasion ◽  
Invasion And Migration ◽  
And Migration ◽  
High Level

Overexpression of c-fos promotes cell invasion and migration via CD44 pathway in oral squamous cell carcinoma

2014 ◽  
Vol 44 (5) ◽  
pp. 353-360 ◽  
Author(s):  
Cong Dong ◽  
Dong-Xia Ye ◽  
Wen-Bin Zhang ◽  
Hong-Ya Pan ◽  
Zhi-Yuan Zhang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Invasion ◽  
Invasion And Migration ◽  
And Migration

scholarly journals MicroRNA-299-3p/FOXP4 Axis Regulates the Proliferation and Migration of Oral Squamous Cell Carcinoma

2019 ◽  
Vol 18 ◽  
pp. 153303381987480 ◽  
Author(s):  
Yaoxiang Xu ◽  
Yanshan Liu ◽  
Wenlin Xiao ◽  
Jin Yue ◽  
Lingfa Xue ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma Cell ◽  
Squamous Cell Carcinoma Cell ◽  
Carcinoma Cell Lines ◽  
Forkhead Box ◽  
And Migration ◽  
Proliferation And Migration

MicroRNAs are noncoding RNAs of 21 to 23 nucleotides in length that play important roles in almost all biological pathways. The roles of microRNA-299-3p in the development and progression of oral squamous cell carcinoma remain unclear. Expression level of microRNA-299-3p in oral squamous cell carcinoma cell lines was analyzed. Then, the effects of microRNA-299-3p on oral squamous cell carcinoma cell proliferation and migration were investigated. Moreover, bioinformation algorithm and Western blot were conducted to explore whether forkhead box P4 was a direct target of miR-299-3p. We showed that microRNA-299-3p expression was significantly reduced in oral squamous cell carcinoma cell lines. Next, overexpression of microRNA-299-3p was found to inhibit oral squamous cell carcinoma cell proliferation and migration but promote apoptosis. In addition, forkhead box P4 was identified as a functional target of microRNA-299-3p. Our results provide a new perspective for the mechanisms underlying the progression of oral squamous cell carcinoma and a novel target for the treatment of oral squamous cell carcinoma.

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