Regulatory effects of vasoactive intestinal peptide on cytokine production in central and peripheral lymphoid organs

1996 ◽  
Vol 6 (1) ◽  
pp. 61-74 ◽  
Author(s):  
Doina Ganea
Keyword(s):  
Vasoactive Intestinal Peptide ◽  
Cytokine Production ◽  
Lymphoid Organs ◽  
Regulatory Effects

scholarly journals Regulatory Effects of 1α,25-Dihydroxyvitamin D3on the Cytokine Production of Human Peripheral Blood Lymphocytes1

1999 ◽  
Vol 84 (10) ◽  
pp. 3739-3744 ◽  
Author(s):  
Martin Willheim ◽  
Ralf Thien ◽  
Karl Schrattbauer ◽  
Erika Bajna ◽  
Margareta Holub ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Cytokine Production ◽  
Human Peripheral Blood ◽  
Regulatory Effects

Regulatory effects of vasoactive intestinal peptide on the migration of mature dendritic cells

2007 ◽  
Vol 182 (1-2) ◽  
pp. 48-54 ◽  
Author(s):  
Yuesong Weng ◽  
Juyun Sun ◽  
Qianqian Wu ◽  
Jianping Pan
Keyword(s):  
Dendritic Cells ◽  
Vasoactive Intestinal Peptide ◽  
Regulatory Effects

Effect of vasoactive intestinal peptide (VIP) on cytokine production and expression of VIP receptors in thymocyte subsets

1997 ◽  
Vol 72 (1) ◽  
pp. 41-54 ◽  
Author(s):  
Zhicheng Xin ◽  
Xiaoming Jiang ◽  
Hong-Ying Wang ◽  
Thomas N Denny ◽  
Bonnie N Dittel ◽  
...  
Keyword(s):  
Vasoactive Intestinal Peptide ◽  
Cytokine Production ◽  
Vip Receptors

scholarly journals Cytokine gene regulation by PGE2, LTB4and PAF

1992 ◽  
Vol 1 (1) ◽  
pp. 5-8 ◽  
Author(s):  
M. Rola-Pleszczynski ◽  
J. Stankova
Keyword(s):  
Gene Expression ◽  
Immune Response ◽  
Gene Regulation ◽  
Inflammatory Response ◽  
Cytokine Production ◽  
Initial Response ◽  
Lipid Mediators ◽  
Cytokine Gene Expression ◽  
Cytokine Gene ◽  
Regulatory Effects

The initial response of the host to noxious stimuli produces a nonspecific inflammatory response. A more specific immune response is believed to be modulated by two classes of molecules: lipid mediators (PG, LT and PAF) and cytokines, synthesized by phagocytes and parenchyreal cells. In this review we discuss the increasing evidence of the interrelationship between eicosanoids, PAF and cytokines: IL-1 and TNF induce PG synthesis in various cells and PG, in turn, modulate cytokine production. We focused on the regulatory effects ofLTB4,PGE2and PAF on cytokine gene expression.

Vasoactive intestinal peptide inhibits cytokine production in T lymphocytes through cAMP-dependent and cAMP-independent mechanisms

1999 ◽  
Vol 84 (1-3) ◽  
pp. 55-67 ◽  
Author(s):  
Hong-Ying Wang ◽  
Xiaoming Jiang ◽  
Illana Gozes ◽  
Mati Fridkin ◽  
Douglas E Brenneman ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Vasoactive Intestinal Peptide ◽  
Cytokine Production

The opioid antagonist naloxone induces a shift from Type 2 to Type 1 cytokine pattern in BALB/cJ mice

Blood ◽  
2000 ◽  
Vol 95 (6) ◽  
pp. 2031-2036 ◽  
Author(s):  
Paola Sacerdote ◽  
Barbara Manfredi ◽  
Leda Gaspani ◽  
Alberto E. Panerai
Keyword(s):  
Opioid Peptides ◽  
Cytokine Production ◽  
Keyhole Limpet Hemocyanin ◽  
Interferon Γ ◽  
Opioid Antagonist ◽  
Immune Functions ◽  
Endogenous Opioid ◽  
Th2 Cytokine ◽  
Regulatory Effects

Abstract Opioid peptides affect different immune functions. We present evidence that these effects could be mediated by the modulation of TH1/TH2 cytokine production. BALB/cJ mice were immunized with 50 or 100 μg of the protein antigen keyhole-limpet hemocyanin (KLH), and treated acutely or chronically with the opioid antagonist naloxone. One and 2 weeks after immunization, the production of cytokines by splenocytes was evaluated by in vitro restimulation with KLH. The acute and chronic treatment with the opioid receptor antagonist naloxone decreased the production of interleukin (IL)–4 by splenocytes of BALB/cJ mice. In contrast, IL-2 and interferon-γ levels increased after naloxone treatment. Finally, the opioid antagonist diminished the serum immunoglobulin G anti–KLH antibody titers. These results suggest that naloxone increases TH1 and decreases TH2 cytokine production. The effect of naloxone could be ascribed to the removal of the regulatory effects exerted by endogenous opioid peptides, which could therefore activate TH2 and suppress TH1 cytokines.

Sign in / Sign up

Export Citation Format

Share Document