scholarly journals P151 Smoking habits and breast cancer: Substantially reduced risk for smokers observed in screening trials using X ray diffraction of hair by synchrotron

The Breast ◽  
2011 ◽  
Vol 20 ◽  
pp. S30
Author(s):  
S. Polizzi ◽  
J. Todhunter ◽  
P. Panarisi ◽  
G. Caruso ◽  
A. Schiavone
2012 ◽  
Author(s):  
A. Konstantinidis ◽  
T. Anaxagoras ◽  
M. Esposito ◽  
N. Allinson ◽  
R. Speller

2009 ◽  
Vol 24 (3) ◽  
pp. 250-253 ◽  
Author(s):  
Peter Varlashkin

The room temperature powder pattern of lapatinib ditosylate monohydrate (active ingredient in Tykerb used to treat refractory breast cancer) was indexed and the cell from the single crystal X-ray diffraction structure was refined using the experimental capillary data. Unit-cell parameters for the orthorhombic compound with space group Pbca refined from powder diffraction data are a=9.6850±0.0009 Å, b=29.364±0.003 Å, and c=30.733±0.003 Å, α=β=γ=90°, z=8, V=8740.1 Å3. Values of 2θ, d, I, and Miller indices are reported.


2012 ◽  
Vol 7 (12) ◽  
pp. C12005-C12005 ◽  
Author(s):  
A Konstantinidis ◽  
Y Zheng ◽  
D Philip ◽  
S Vinnicombe ◽  
R Speller

2007 ◽  
Vol 122 (4) ◽  
pp. 847-856 ◽  
Author(s):  
Gary L. Corino ◽  
Peter W. French

Crystals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 344
Author(s):  
Madiha Batool ◽  
Shazia Khurshid ◽  
Walid M. Daoush ◽  
Sabir Ali Siddique ◽  
Tariq Nadeem

The present study aimed to develop the synthesis of zinc oxide nanoparticles (ZnO-NPs) using the green method, with Aloe barbadensis leaf extract as a stabilizing and capping agent. In vitro antitumor cytotoxic activity, as well as the surface-functionalization of ZnO-NPs and their drug loading capacity against doxorubicin (DOX) and gemcitabine (GEM) drugs, were also studied. Morphological and structural properties of the produced ZnO-NPs were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersion X-ray diffraction (EDX), UV-Vis spectrophotometry, Fourier-transform infrared analysis (FTIR), and X-ray diffraction (XRD). The prepared ZnO-NPs had a hexagonal shape and average particle size of 20–40 nm, with an absorption peak at 325 nm. The weight and atomic percentages of zinc (50.58% and 28.13%) and oxygen (26.71% and 60.71%) were also determined by EDAX (energy dispersive x-ray analysis) compositional analysis. The appearance of the FTIR peak at 3420 m–1 confirmed the synthesis of ZnO-NPs. The drug loading efficiency (LE) and loading capacity (LC) of unstabilized and PEGylated ZnO-NPs were determined by doxorubicin (DOX) and gemcitabine (GEM) drugs. DOX had superior LE 65% (650 mg/g) and higher LC 32% (320 mg/g) than GEM LE 30.5% (30 mg/g) and LC 16.25% (162 mg/g) on ZnO-NPs. Similar observation was observed in the case of PEG-ZnO-NPs, where DOX had enhanced LE 68% (680 mg/g) and LC 35% (350) mg/g in contrast to GEM, which had LE and LC values of 35% (350 mg/g) and 19% (190 mg/g), respectively. Therefore, DOX was chosen to encapsulate nanoparticles, along with the untreated nanoparticles, to check their in vitro antiproliferative potential against the triple-negative breast cancer (TNBC) cell line (MDA-MB-231) through the MTT (3-(4,5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide) assay. This drug delivery strategy implies that the PEGylated biogenically synthesized ZnO-NPs occupy an important position in chemotherapeutic drug loading efficiency and can improve the therapeutic techniques of triple breast cancer.


2012 ◽  
Vol 6 ◽  
pp. BCBCR.S9607 ◽  
Author(s):  
Dharmica A.H. Mistry ◽  
Joseph Haklani ◽  
Peter W. French

A correlation between the presence of breast cancer and a change in the synchrotron-generated X-ray diffraction (XRD) pattern of hair has been reported in several publications by different groups, and on average XRD-based assays detect around 75% of breast cancer patients in blinded studies. To date, the molecular mechanisms leading to this alteration are largely unknown. We have determined that the alteration is likely to be due to the presence of one or more breast cancer-associated phospholipids. Further characterization of these lipids could be used to develop a novel, sensitive and specific screening test for breast cancer, based on hair initially, and potentially extendable to other biological samples.


2008 ◽  
Vol 26 (15_suppl) ◽  
pp. 20732-20732
Author(s):  
J. M. Beith ◽  
G. Corino ◽  
P. French

2016 ◽  
Vol 14 (2) ◽  
pp. 153-158
Author(s):  
A. Maziar ◽  
D. Shahbazi-Gahrouei ◽  
M.B. Tavakoli ◽  
V. Changizi ◽  
Z. Ghasemian ◽  
...  

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