Cardiac troponin I as an early marker of myocardial damage after coronary bypass surgery

Introduction The present study was undertaken to investigate the prognostic value of the frontal QRS-T angle associated with adverse cardiac outcomes in patients with carbon monoxide (CO) poisoning in early stages in the emergency department. Materials and methods The data of 212 patients with CO poisoning who were admitted to the ED between January 2010 and May 2020 were retrospectively analyzed. The frontal QRS-T angle was obtained from the automatic reports of the EKG device. Results Compared to patients without myocardial damage, among patients with myocardial damage, statistically high creatinine, creatine kinase MB, cardiac troponin I, and frontal QRS-T angle values were found ( p < 0.001 for all parameters), while the saturation of arterial blood pH and arterial oxygen values were found to be lower ( p = 0.002 and p < 0.001, respectively). The frontal QRS-T angle values were correlated with creatine kinase, creatine kinase-MB, cardiac troponin I, and oxygen saturation (SpO2) in arterial blood (r = 0. 232, p = 0.001; r = 0. 253, p = < 0.001; r = 0. 389, p = < 0.001; r = −0. 198, p = 0.004, respectively). The optimum cut-off value of the frontal QRS-T angle was found to be 44.5 (area under the curve: 0.901, 95% confidence interval: 0.814–0.988, sensitivity: 87%, specificity: 84%). Conclusions The frontal QRS-T angle, a simple and inexpensive parameter that can be easily obtained from 12-lead surface electrocardiography, can be used as an early indicator in the detection of myocardial damage in patients with CO poisoning.

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Myocardial damage following coronary bypass surgery: assessment with antimyosin antibody uptake

British Journal of Radiology ◽

10.1259/0007-1285-65-780-1086 ◽

1992 ◽

Vol 65 (780) ◽

pp. 1086-1092

Author(s):

A. Jiménez-Heffernan ◽

J. M. Latre ◽

M. Concha ◽

M. Torres ◽

M. Martínez-Paredes ◽

...

Keyword(s):

Bypass Surgery ◽

Coronary Bypass ◽

Myocardial Damage ◽

Coronary Bypass Surgery ◽

Antimyosin Antibody ◽

Antibody Uptake

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Evaluation of Myocardial Damage After Electroconvulsive Therapy: Analyses of High-Sensitive Cardiac Troponin I and N-Terminal pro-B-type Natriuretic Peptide

Pharmacopsychiatry ◽

10.1055/a-0646-4278 ◽

2018 ◽

Vol 52 (02) ◽

pp. 92-93

Author(s):

Laura Kranaster ◽

Johanna Badstübner ◽

Suna Aksay ◽

Jan Bumb ◽

Rayan Suliman ◽

...

Keyword(s):

Natriuretic Peptide ◽

Electroconvulsive Therapy ◽

Cardiac Troponin ◽

Cardiovascular Events ◽

Troponin I ◽

Myocardial Damage ◽

Cardiac Troponin I ◽

Safe Procedure ◽

Increased Risk ◽

Before And After

AbstractElectroconvulsive therapy (ECT) is a remarkably safe procedure. However, there might exist a subgroup of patients with an increased risk for cardiovascular events. The cardiac-specific enzymes high-sensitive cardiac troponin I (hscTnI) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were measured before and after ECT in 23 patients. No relevant increase of hscTnI after ECT was found. Mean NT-proBNP levels were higher after ECT and in three patients a new NT-proBNP elevation after ECT was identified. In conclusion, our small study did not find any evidence for myocardial damage due to ECT by measuring hsTnI, but an increase of NT-proBNP, whose clinical relevance could only be speculated, yet.

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Pre-cardiopulmonary bypass administration of dexmedetomidine decreases cardiac troponin I level following cardiac surgery with sevoflurane postconditioning

Journal of International Medical Research ◽

10.1177/0300060519856750 ◽

2019 ◽

Vol 47 (8) ◽

pp. 3623-3635

Author(s):

Hong-mei Zhou ◽

Xiao-yan Ling ◽

Yun-jian Ni ◽

Cheng Wu ◽

Zhi-peng Zhu

Keyword(s):

New York ◽

Cardiac Surgery ◽

Cardiopulmonary Bypass ◽

Cardiac Troponin ◽

Troponin I ◽

Myocardial Damage ◽

Heart Association ◽

Cardiac Troponin I ◽

Sevoflurane Postconditioning ◽

Ctni Level

Objective This study was performed to determine the effect of dexmedetomidine (DEX) administration on myocardial damage in cardiac surgery with sevoflurane postconditioning. Methods We retrospectively examined all cardiac valve replacement surgeries from 1 April 2016 to 30 April 2017. Eligible patients were divided into two groups based on whether DEX was infused. DEX infusion was permitted only between intubation and the beginning of cardiopulmonary bypass (CPB). Sevoflurane was inhaled via the standard postconditioning procedure starting at aortic declamping. The cardiac troponin I (cTnI) level was measured at different time points. The postoperative outcomes and complications were also analyzed. Results One hundred patients were included in the study (DEX group, n = 53; non-DEX group, n = 47). Increased cTnI levels were significantly correlated with the New York Heart Association classification, CPB time, and DEX use. DEX use and the CPB time were potential independent factors contributing to changes in the cTnI level. The cTnI level at 6, 12, and 24 hours postoperatively was remarkably lower in the DEX than non-DEX group by 1.14, 7.83, and 5.86 ng/mL, respectively. Conclusions DEX decreased the cTnI level after CPB when sevoflurane postconditioning was used, especially at 6, 12, and 24 hours postoperatively.

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Preoperative Cardiac Troponin I to Assess Midterm Risks of Coronary Bypass Grafting Operations in Patients With Recent Myocardial Infarction

The Annals of Thoracic Surgery ◽

10.1016/j.athoracsur.2009.11.072 ◽

2010 ◽

Vol 89 (3) ◽

pp. 696-702 ◽

Cited By ~ 14

Author(s):

Domenico Paparella ◽

Giuseppe Scrascia ◽

Andreas Paramythiotis ◽

Pietro Guida ◽

Vito Magari ◽

...

Keyword(s):

Myocardial Infarction ◽

Cardiac Troponin ◽

Troponin I ◽

Coronary Bypass ◽

Cardiac Troponin I ◽

Bypass Grafting ◽

Recent Myocardial Infarction ◽

Coronary Bypass Grafting

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NILAI DIAGNOSTIK UJI TROPONIN I KUANTITATIF METODE IMMUNOKROMATOGRAFI

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v14i1.920 ◽

2018 ◽

Vol 14 (1) ◽

pp. 20

Author(s):

Siti Fatonah ◽

Anik Widijanti ◽

Tinny Endang Hernowati

Keyword(s):

Cardiac Troponin ◽

Biochemical Markers ◽

Acute Coronary Syndromes ◽

Troponin I ◽

Myocardial Damage ◽

Diagnostic Value ◽

Cardiac Troponin I ◽

Coronary Syndromes ◽

Sensitivity Specificity ◽

Cardiac Troponins

Cardiac troponins are the most sensitive and specific biochemical markers of myocardial damage but there is no standardization of WHO for cardiac troponin I, resulting in a variability for diagnostic value. It is necessary to determine diagnostic value for a new kitof troponin I. To evaluate a new quantitative immunochromatography assay for troponin I at a various cut off level. A cross sectionalstudy was conducted in 64 patients with acute myocardial infarction (AMI) and 55 non-AMI as control from February to September2007. The level of cardiac troponin I (cTnI) was measured and determined it diagnostic value at a various cut off level. The sensitivity,specificity, PPV and NPV of this assay were 91%, 91%, 92% and 89% at cut off level of 1,0 ng/ml (according to the kit), respectively.The cut off of cTnI were divided into five levels: 0.8, 1.0, 1.2, 1.5, and 2.0 with the area under curve were 0.923, 0.908, 0.912, and0.897, respectively. The sensitivity were 94%, 91%, 86%, 81% and 72%, respectively, the specificity were 91%, 91%, 96%, 98% and98%, respectively. This rapid diagnostic test is sensitive and specific to diagnose an acute coronary syndromes.

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