4 Type-specific regulation of mammalian adenylyl cyclases by G protein pathways

1997 ◽  
pp. 81-98 ◽  
Author(s):  
Ronald Taussig ◽  
Gregor Zimmermann
Keyword(s):  
G Protein ◽  
Adenylyl Cyclases ◽  
Specific Regulation

scholarly journals Role for G protein-coupled receptor kinase in agonist-specific regulation of  -opioid receptor responsiveness

1998 ◽  
Vol 95 (12) ◽  
pp. 7157-7162 ◽  
Author(s):  
J. Zhang ◽  
S. S. G. Ferguson ◽  
L. S. Barak ◽  
S. R. Bodduluri ◽  
S. A. Laporte ◽  
...  
Keyword(s):  
G Protein ◽  
Opioid Receptor ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Specific Regulation ◽  
G Protein Coupled

scholarly journals Adenylyl cyclases (ACs) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

2019 ◽  
Vol 2019 (4) ◽  
Author(s):  
Carmen W. Dessauer ◽  
Rennolds Ostrom ◽  
Roland Seifert ◽  
Val J. Watts
Keyword(s):  
Cyclic Amp ◽  
Adenylyl Cyclase ◽  
G Protein ◽  
Adenylyl Cyclases ◽  
Adenylyl Cyclase Activity ◽  
Α Subunit ◽  
Soluble Adenylyl Cyclase ◽  
Catalytic Domains ◽  
Stimulatory G Protein ◽  
Membrane Spanning

Adenylyl cyclase, E.C. 4.6.1.1, converts ATP to cyclic AMP and pyrophosphate. Mammalian membrane-delimited adenylyl cyclases (nomenclature as approved by the NC-IUPHAR Subcommittee on Adenylyl cyclases [9]) are typically made up of two clusters of six TM domains separating two intracellular, overlapping catalytic domains that are the target for the nonselective activators Gαs (the stimulatory G protein α subunit) and forskolin (except AC9, [21]). adenosine and its derivatives (e.g. 2',5'-dideoxyadenosine), acting through the P-site,are inhibitors of adenylyl cyclase activity [27]. Four families of membranous adenylyl cyclase are distinguishable: calmodulin-stimulated (AC1, AC3 and AC8), Ca2+- and Gβγ-inhibitable (AC5, AC6 and AC9), Gβγ-stimulated and Ca2+-insensitive (AC2, AC4 and AC7), and forskolin-insensitive (AC9) forms. A soluble adenylyl cyclase (AC10) lacks membrane spanning regions and is insensitive to G proteins.It functions as a cytoplasmic bicarbonate (pH-insensitive) sensor [5].

scholarly journals Stimulation of Mammalian G-protein-responsive Adenylyl Cyclases by Carbon Dioxide

2008 ◽  
Vol 284 (2) ◽  
pp. 784-791 ◽  
Author(s):  
Philip D. Townsend ◽  
Phillip M. Holliday ◽  
Stepan Fenyk ◽  
Kenneth C. Hess ◽  
Michael A. Gray ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
G Protein ◽  
Adenylyl Cyclases ◽  
Stimulation Of

Conditional regulation of adenylyl cyclases by G-protein βγ-subunits

1993 ◽  
Vol 21 (4) ◽  
pp. 1132-1138 ◽  
Author(s):  
Natsuo Ueda ◽  
Wei-Jen Tang
Keyword(s):  
G Protein ◽  
Adenylyl Cyclases

Tissue- and subunit-specific regulation of G-protein expression by hypo- and hyperthyroidism

1993 ◽  
Vol 45 (7) ◽  
pp. 1417-1423 ◽  
Author(s):  
Martina B. Michel-Reher ◽  
Gerhard Gross ◽  
Jeffrey R. Jasper ◽  
Daniel Bernstein ◽  
Thomas Olbricht ◽  
...  
Keyword(s):  
Protein Expression ◽  
G Protein ◽  
Specific Regulation
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