Averaging flat maps of hippocampal activity across subjects

NeuroImage ◽  
2000 ◽  
Vol 11 (5) ◽  
pp. S537 ◽  
Author(s):  
Michael Zeineh ◽  
Paul Thompson ◽  
Stephen Engel ◽  
Susan Bookheimer
Keyword(s):  
Hippocampal Activity ◽  
Flat Maps

scholarly journals MEG detects abnormal hippocampal activity in amyloid‐positive MCI

2020 ◽  
Vol 16 (S4) ◽  
Author(s):  
Janne Luppi ◽  
Deborah N Schoonhoven ◽  
Anne M van Nifterick ◽  
Hillebrand Arjan ◽  
Alida A Gouw ◽  
...  
Keyword(s):  
Hippocampal Activity

scholarly journals Cortical amyloid burden and age moderate hippocampal activity in cognitively-normal adults

2016 ◽  
Vol 12 ◽  
pp. 78-84 ◽  
Author(s):  
Zhuang Song ◽  
Ian M. McDonough ◽  
Peiying Liu ◽  
Hanzhang Lu ◽  
Denise C. Park
Keyword(s):  
Amyloid Burden ◽  
Cognitively Normal ◽  
Hippocampal Activity ◽  
Normal Adults

scholarly journals Interactions between hippocampal activity and striatal dopamine in people at clinical high risk for psychosis: relationship to adverse outcomes

2021 ◽  
Author(s):  
Gemma Modinos ◽  
Anja Richter ◽  
Alice Egerton ◽  
Ilaria Bonoldi ◽  
Matilda Azis ◽  
...  
Keyword(s):  
High Risk ◽  
Functional Outcomes ◽  
Mental States ◽  
Adverse Outcomes ◽  
Striatal Dopamine ◽  
Psychotic Symptoms ◽  
Dopamine Synthesis ◽  
Clinical High Risk ◽  
Hippocampal Activity ◽  
The Relationship

AbstractPreclinical models propose that increased hippocampal activity drives subcortical dopaminergic dysfunction and leads to psychosis-like symptoms and behaviors. Here, we used multimodal neuroimaging to examine the relationship between hippocampal regional cerebral blood flow (rCBF) and striatal dopamine synthesis capacity in people at clinical high risk (CHR) for psychosis and investigated its association with subsequent clinical and functional outcomes. Ninety-five participants (67 CHR and 28 healthy controls) underwent arterial spin labeling MRI and 18F-DOPA PET imaging at baseline. CHR participants were followed up for a median of 15 months to determine functional outcomes with the global assessment of function (GAF) scale and clinical outcomes using the comprehensive assessment of at-risk mental states (CAARMS). CHR participants with poor functional outcomes (follow-up GAF < 65, n = 25) showed higher rCBF in the right hippocampus compared to CHRs with good functional outcomes (GAF ≥ 65, n = 25) (pfwe = 0.026). The relationship between rCBF in this right hippocampal region and striatal dopamine synthesis capacity was also significantly different between groups (pfwe = 0.035); the association was negative in CHR with poor outcomes (pfwe = 0.012), but non-significant in CHR with good outcomes. Furthermore, the correlation between right hippocampal rCBF and striatal dopamine function predicted a longitudinal increase in the severity of positive psychotic symptoms within the total CHR group (p = 0.041). There were no differences in rCBF, dopamine, or their associations in the total CHR group relative to controls. These findings indicate that altered interactions between the hippocampus and the subcortical dopamine system are implicated in the pathophysiology of adverse outcomes in the CHR state.

scholarly journals Neural Circuitry–Neurogenesis Coupling Model of Depression

2021 ◽  
Vol 22 (5) ◽  
pp. 2468
Author(s):  
Il Bin Kim ◽  
Seon-Cheol Park
Keyword(s):  
Entorhinal Cortex ◽  
Coupling Model ◽  
Neural Circuitry ◽  
Hippocampal Neurogenesis ◽  
Pattern Separation ◽  
Dependent Process ◽  
Hippocampal Activity ◽  
Mechanistic Understanding ◽  
Activity Dependent ◽  
Memory Pattern

Depression is characterized by the disruption of both neural circuitry and neurogenesis. Defects in hippocampal activity and volume, indicative of reduced neurogenesis, are associated with depression-related behaviors in both humans and animals. Neurogenesis in adulthood is considered an activity-dependent process; therefore, hippocampal neurogenesis defects in depression can be a result of defective neural circuitry activity. However, the mechanistic understanding of how defective neural circuitry can induce neurogenesis defects in depression remains unclear. This review highlights the current findings supporting the neural circuitry-regulated neurogenesis, especially focusing on hippocampal neurogenesis regulated by the entorhinal cortex, with regard to memory, pattern separation, and mood. Taken together, these findings may pave the way for future progress in neural circuitry–neurogenesis coupling studies of depression.

Frobenius closure and prime characteristic singularities

2020 ◽  
Author(s):  
◽  
Kyle Logan Maddox
Keyword(s):  
Local Ring ◽  
Local Cohomology ◽  
Sufficient Condition ◽  
Zariski Topology ◽  
Prime Characteristic ◽  
Joint Work ◽  
University Of Missouri ◽  
Mild Conditions ◽  
Flat Maps ◽  
The University

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] This dissertation outlines several results about prime characteristic singularities for which the nilpotent part under the induced Frobenius action on local cohomology is either finite colength or the entire module, collectively referred to here as nilpotent singularities. First, we establish a sufficient condition for the finiteness of the Frobenius test exponent for a local ring and apply it to conclude that nilpotent singularities have finite Frobenius test exponent. In joint work with Jennifer Kenkel, Thomas Polstra, and Austyn Simpson, we show that under mild conditions nilpotent singularities descend and ascend along faithfully flat maps. Consequently, we then prove that the loci of primes which are weakly F-nilpotent and F-nilpotent are open in the Zariski topology for rings which are either F-finite or essentially of fiiite type over an excellent local ring.

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