Comparison of laser-Doppler flowmetry with biochemical indicators of endothelial dysfunction related to early microangiopathy in Type 1 diabetic patients

2001 ◽  
Vol 15 (5) ◽  
pp. 234-240 ◽  
Author(s):  
Jan Škrha ◽  
Martin Prázný ◽  
Tomáš Haas ◽  
Jan Kvasnička ◽  
Bohdana Kalvodová
Keyword(s):  
Endothelial Dysfunction ◽  
Laser Doppler Flowmetry ◽  
Laser Doppler ◽  
Diabetic Patients ◽  
Doppler Flowmetry ◽  
Biochemical Indicators ◽  
Type 1 Diabetic Patients

Peculiarities of microcirculation in periodont tissues in children of key age groups sufficient type 1 diabetes. Part II

2019 ◽  
Vol 24 (2) ◽  
pp. 108-119 ◽  
Author(s):  
B. N. Davydov ◽  
D. A. Domenyuk ◽  
S. V. Dmitrienko
Keyword(s):  
Diabetes Mellitus ◽  
Blood Flow ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Laser Doppler Flowmetry ◽  
Laser Doppler ◽  
Diabetic Microangiopathy ◽  
Healthy Children ◽  
Doppler Flowmetry

Relevance. Morpho-functional changes in peripheral circulation established in type 1 diabetes mellitus correlate with changes in central hemodynamics, allowing the use of microcirculation indicators as diagnostic and prognostic criteria for assessing the degree of functional vascular disorders. Identifcation of microcirculation features of the blood by the method of laser Doppler flowmetry in children with different experience of type 1 diabetes in key age categories.Materials and methods. The study included 67 children with type 1 diabetes mellitus aged 12-15 years with an experience of the disease from six months to ten years. The comparison group consisted of 38 healthy children. The state of the microvasculature was assessed by laser Doppler flowmetry using a laser analyzer for capillary blood flow LAKK-OP.Results. In children with an experience of type 1 diabetes of less than two years, microcirculation disorders in periodontal tissues correspond to the hyperemic form, accompanied by increased perfusion, a decrease in the amplitude of low-frequency oscillations, increased heart rate, high blood flling, and blood flow bypass. For children with an endocrinopathy experience of more than three years, microcirculation disorders correspond to a stagnant form, combined with a decrease in perfusion due to stagnation of blood in the venular link, endothelial domination with suppression of neurogenic and cardiac fluctuations, low efciency and redistribution of blood flow in favor of the nutritive link.Conclusions. With the increase in experience, the degree of compensation of type 1 diabetes, the progression of diabetic microangiopathy, it is advisable to designate two stages of development of microcirculatory disorders. Early – compensatory with active adaptation, including neurogenic and endothelial regulation mechanisms. Late – decompensation with passive adaptation, supporting the effectiveness of microcirculation due to myogenic control of regulation, shunting and increasing the rate of blood outflow.

Low-density lipoproteins from type 1 diabetic patients induce in vitro endothelial dysfunction

1999 ◽  
Vol 144 ◽  
pp. 57
Author(s):  
R.A. Rabini ◽  
R. Staffolani ◽  
E. Salvolini ◽  
D. Martarelli ◽  
A. Vignini
Keyword(s):  
Endothelial Dysfunction ◽  
Low Density Lipoproteins ◽  
Diabetic Patients ◽  
Low Density ◽  
Type 1 Diabetic Patients

Carotid intimal medial thickness and its relation to endothelial dysfunction and echocardiographic changes in adolescents with type 1 diabetes

2015 ◽  
Vol 28 (9-10) ◽  
Author(s):  
Soha M. Abd El Dayem ◽  
Abo El Magd El Bohy ◽  
Ahmed A. Battah
Keyword(s):  
Endothelial Dysfunction ◽  
Flow Velocity ◽  
Left Ventricular ◽  
Diabetic Patients ◽  
Creatinine Ratio ◽  
Albumin Creatinine Ratio ◽  
Mitral Flow ◽  
Carotid Intimal Medial Thickness ◽  
Type 1 Diabetic Patients

AbstractTo assess carotid intimal medial thickness (cIMT) in adolescent type 1 diabetic patients and to detect its relation with echocardiographic changes and flow mediated dilatation (FMD) in the brachial artery.The study included 62 type 1 diabetic patients and 30 healthy volunteer of the same age and sex. A blood sample was taken for analysis of glycosylated hemoglobin and lipid profile and a urine sample was taken for analysis of albumin/creatinine ratio. cIMT, echocardiography, and FMD via ultrasound were also done; t-test or Mann-Whitney U-test (for non-symmetrically distributed data) for independent variables and Pearson’s or Spearman correlation were used.The mean age of patients was 16.3±1.5 years and mean duration of diabetes was 9.4±2.9 years. cIMT (Rt, Lt, and both Rt and Lt) were significantly higher, while FMD and FMD/nitrate mediated dilatation (NMD) ratio was significantly lower in diabetics. Rt cIMT had a significant negative correlation with FMD and FMD/NMD. cIMT had a significant positive correlation with left ventricular end diastolic dimension, inter ventricular septum thickness, peak mitral flow velocity during early diastole/peak mitral flow velocity during late diastole, left ventricular mass, and left ventricular mass index (p<0.05). In addition, cIMT had a significant correlation with waist circumference, waist/height ratio, albumin/ creatinine ratio, total cholesterol, and triglyceride.We conclude that alteration in myocardial function and vascular endothelial dysfunction induced by diabetes mellitus may begin early with the association of early atherosclerotic changes.

scholarly journals Serum levels of endothelial monocyte activating polypeptide-II in type 1 diabetes patients with microangyopathy and arterial hypertention.

2016 ◽  
Vol 19 (4) ◽  
pp. 309-314 ◽  
Author(s):  
Liliya A. Mogylnytska ◽  
Boris N. Mankovsky
Keyword(s):  
Type 1 Diabetes ◽  
Endothelial Dysfunction ◽  
Serum Level ◽  
Arterial Hypertension ◽  
Diabetic Patient ◽  
Serum Levels ◽  
Diabetic Patients ◽  
Emap Ii ◽  
Type 1 Diabetic Patients

Aim. Тo determine the serum level of EMAP-II in type 1 diabetic patients with microangyopathy and arterial hypertention.Materials and methods We examined 23 type 1 diabetic patient with microangyopathy and arterial hypertention, 10 type 1 diabetic patient with microangyopathy without hypertention and 28 control subjects. Serum levels of EMAP-II were determined by immunoenzyme assay. The data were presented as means±SD.  Results. We found an increased serum level of EMAP-II in type 1 diabetic patients with microangyopathy and arterial hypertention compared to control group (5,23±1,66 ng/ml and 1,25±0,76 ng/ml respectively, р0,01), and in type 1 diabetic patients with microangyopathy and arterial hypertension compared to group without hypertension (5,23±1,66 ng/ml and 3,63±1,9 ng/ml respectively, р0,01). Also, the level of EMAP-II correlated with key markers of carbohydrate and lipid metabolism, inverse correlated with endothelium-dependent dilatation (p0,05).Conclusion. The revealed change of EMAP-II could reflect an endothelial dysfunction in patients with type 1 diabetes with microangyopathy and arterial hypertension. Arterial hypertension, hyperglycemia, dyslipidemia appears to be significant factor to contributing elevation of EMAP-II.Keywords: Endothelial monocyte activating polypeptide II, endothelial dysfunction, type 1 diabetes, arterial hypertension.

Assessment of cutaneous microcirculation by laser Doppler flowmetry in type 1 diabetes

2019 ◽  
Vol 124 ◽  
pp. 91-96 ◽  
Author(s):  
Michele Sorelli ◽  
Piergiorgio Francia ◽  
Leonardo Bocchi ◽  
Alessandra De Bellis ◽  
Roberto Anichini
Keyword(s):  
Type 1 Diabetes ◽  
Laser Doppler Flowmetry ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
Cutaneous Microcirculation
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