Microanatomy of pregnant human myometrium. Structural evidence for electrical and paracrine signaling mechanisms

1998 ◽  
Vol 5 (1) ◽  
pp. 177A-177A
Author(s):  
R YOUNG ◽  
R HESSION
Keyword(s):  
Human Myometrium ◽  
Paracrine Signaling ◽  
Signaling Mechanisms

scholarly journals Estrogen action on the prostate gland: a critical mix of endocrine and paracrine signaling

2007 ◽  
Vol 39 (3) ◽  
pp. 183-188 ◽  
Author(s):  
Gail P Risbridger ◽  
Stuart J Ellem ◽  
Stephen J McPherson
Keyword(s):  
Prostate Gland ◽  
Hormone Action ◽  
Autocrine Signaling ◽  
Paracrine Signaling ◽  
Estrogen Action ◽  
Signaling Mechanisms ◽  
Molecular Events ◽  
Modern Biotechnology ◽  
New Strategies

Although modern biotechnology has provided us with a greater understanding of the molecular events in endocrine-related diseases, such as benign prostatic hyperplasia and prostate cancer, these conditions continue to be a significant healthcare problem world-wide. As the number of men afflicted by these diseases will only continue to grow with the aging population, finding new strategies and new therapeutic options for the treatment of both of these diseases is crucial. A better knowledge of the mechanisms of hormone action is pivotal to making progress in the development of new hormone-based therapies. This is fundamental to increasing our understanding of the endocrine, paracrine, and autocrine signaling mechanisms in the prostate and in prostate disease, distinguishing the effects and role of each, and identifying where and how this communication goes wrong.

scholarly journals Nutritional status and fecundity are synchronised by muscular exopheresis

2020 ◽  
Author(s):  
Michał Turek ◽  
Małgorzata Piechota ◽  
Katarzyna Banasiak ◽  
Nilesh Shanmugam ◽  
Matylda Macias ◽  
...  
Keyword(s):  
Body Wall ◽  
Energy Resources ◽  
Reproductive Capacity ◽  
Primary Role ◽  
Paracrine Signaling ◽  
Yolk Proteins ◽  
Egg Formation ◽  
Signaling Mechanisms ◽  
Body Wall Muscles

AbstractOrganismal functionality and reproduction depend on metabolic rewiring and balanced energy resources. However, the crosstalk between organismal homeostasis and fecundity, and the associated paracrine signaling mechanisms are still poorly understood. Using the Caenorhabditis elegans we discovered that large extracellular vesicles termed exophers, attributed in neurons and cardiomyocytes to the removal of damaged subcellular components, are released by body wall muscles to support embryonic growth. We found that exopher formation (exopheresis) is a non-cell autonomous process regulated by egg formation in the uterus. Our data suggest that exophers serve as transporters for muscle-generated yolk proteins used for nourishing and improving the growth rate of the next generation. We propose that the primary role of muscular exopheresis is to stimulate the reproductive capacity, thereby influencing the adaptation of worm populations to the current environmental conditions.

EXPERIMENTS ON THE ENDOCRINE CONTROL OF THE ACTIVITY OF THE NONPREGNANT HUMAN MYOMETRIUM

1965 ◽  
Vol 49 (3_Suppl) ◽  
pp. S202
Author(s):  
L. Ph. Bengtsson ◽  
G. W. Theobald
Keyword(s):  
Human Myometrium ◽  
Endocrine Control
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