scholarly journals A Structural Basis for the Selection of Dominant αβ T Cell Receptors in Antiviral Immunity

Immunity ◽  
2003 ◽  
Vol 18 (1) ◽  
pp. 53-64 ◽  
Author(s):  
Lars Kjer-Nielsen ◽  
Craig S. Clements ◽  
Anthony W. Purcell ◽  
Andrew G. Brooks ◽  
James C. Whisstock ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptors ◽  
Antiviral Immunity ◽  
Structural Basis ◽  
Cell Receptors ◽  
Selection Of

Abstract 2564: Selection of affinity-enhanced T-cell receptors for adoptive T-cell therapy targeting MAGE-A10

2018 ◽  
Author(s):  
Ellen Border ◽  
Joseph P. Sanderson ◽  
Thomas Weissensteiner ◽  
Natalie Hyland ◽  
Tom Holdich ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Therapy ◽  
T Cell Receptors ◽  
Adoptive T Cell Therapy ◽  
T Cell Therapy ◽  
Cell Receptors ◽  
Selection Of

scholarly journals Affinity-enhanced T-cell receptors for adoptive T-cell therapy targeting MAGE-A10: strategy for selection of an optimal candidate

2018 ◽  
Vol 8 (2) ◽  
pp. e1532759 ◽  
Author(s):  
Ellen C. Border ◽  
Joseph P. Sanderson ◽  
Thomas Weissensteiner ◽  
Andrew B. Gerry ◽  
Nicholas J. Pumphrey
Keyword(s):  
T Cell ◽  
Cell Therapy ◽  
T Cell Receptors ◽  
Adoptive T Cell Therapy ◽  
T Cell Therapy ◽  
Cell Receptors ◽  
Optimal Candidate ◽  
Selection Of

scholarly journals The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Philippa Marrack ◽  
Sai Harsha Krovi ◽  
Daniel Silberman ◽  
Janice White ◽  
Eleanor Kushnir ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
T Cell ◽  
Positive Selection ◽  
T Cell Receptor ◽  
T Cell Receptors ◽  
Cell Receptor ◽  
Structural Basis ◽  
Major Histocompatibility ◽  
Cell Receptors ◽  
Histocompatibility Complex

Mature T cells bearing αβ T cell receptors react with foreign antigens bound to alleles of major histocompatibility complex proteins (MHC) that they were exposed to during their development in the thymus, a phenomenon known as positive selection. The structural basis for positive selection has long been debated. Here, using mice expressing one of two different T cell receptor β chains and various MHC alleles, we show that positive selection-induced MHC bias of T cell receptors is affected both by the germline encoded elements of the T cell receptor α and β chain and, surprisingly, dramatically affected by the non germ line encoded portions of CDR3 of the T cell receptor α chain. Thus, in addition to determining specificity for antigen, the non germline encoded elements of T cell receptors may help the proteins cope with the extremely polymorphic nature of major histocompatibility complex products within the species.

scholarly journals Expansion of natural (NK1+) T cells that express alpha beta T cell receptors in transporters associated with antigen presentation-1 null and thymus leukemia antigen positive mice.

1996 ◽  
Vol 184 (4) ◽  
pp. 1579-1584 ◽  
Author(s):  
S Joyce ◽  
I Negishi ◽  
A Boesteanu ◽  
A D DeSilva ◽  
P Sharma ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Antigen Presentation ◽  
T Cell Receptors ◽  
T Cell Development ◽  
Cell Development ◽  
Cell Receptors ◽  
Alpha Beta ◽  
Class Ib ◽  
Selection Of

Thymic selection of natural killer-1+ natural T cells that express alpha beta T cell receptors requires a conserved beta 2-microglobulin-associated molecule, presumably CD1d, displayed by CD4+8+ thymocytes. Here we demonstrate that positive selection of natural T cells occurs independent of transporters associated with antigen presentation-1 (TAP-1) function. Moreover, natural T cells in TAP-1o/o mice are numerically expanded. Several H-2 class Ib molecules function in a TAP-independent manner, suggesting that if expressed in TAP-1o/o thymocytes, they could play a role in natural T cell development. Of these class Ib molecules, H-2TL is expressed by TAP-1o/o thymocytes. Moreover, we find that thymi of TL+ mice congenic or transgenic for H-2T18 also have a numerically expanded natural T cell repertoire compared with TL- mice. This expansion, as in TAP-1o/o thymi, is evident in each of the limited T cell receptor V beta chains expressed by natural T cells, suggesting that TL and CD1d impact similar repertoires. Thus TL, in addition to CD1d, plays a role in natural T cell development.

scholarly journals Structural Basis of Specificity and Cross-Reactivity in T Cell Receptors Specific for Cytochrome c–I-Ek

2011 ◽  
Vol 186 (10) ◽  
pp. 5823-5832 ◽  
Author(s):  
Evan W. Newell ◽  
Lauren K. Ely ◽  
Andrew C. Kruse ◽  
Philip A. Reay ◽  
Stephanie N. Rodriguez ◽  
...  
Keyword(s):  
T Cell ◽  
Cytochrome C ◽  
T Cell Receptors ◽  
Cross Reactivity ◽  
Structural Basis ◽  
Cell Receptors

Structural basis for self-recognition by autoimmune T-cell receptors

2012 ◽  
Vol 250 (1) ◽  
pp. 32-48 ◽  
Author(s):  
Yiyuan Yin ◽  
Yili Li ◽  
Roy A. Mariuzza
Keyword(s):  
T Cell ◽  
T Cell Receptors ◽  
Structural Basis ◽  
Cell Receptors ◽  
Self Recognition

scholarly journals Structural insights into an affinity-based selection of virus-specific public T cell receptors

2008 ◽  
Vol 64 (a1) ◽  
pp. C314-C315
Author(s):  
J.-B. Reiser ◽  
S. Gras ◽  
X. Saulquin ◽  
B. Neveu ◽  
A. Chouquet ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptors ◽  
Cell Receptors ◽  
Structural Insights ◽  
Selection Of

scholarly journals Thymic Selection of T-Cell Receptors as an Extreme Value Problem

2009 ◽  
Vol 103 (6) ◽  
Author(s):  
Andrej Košmrlj ◽  
Arup K. Chakraborty ◽  
Mehran Kardar ◽  
Eugene I. Shakhnovich
Keyword(s):  
T Cell ◽  
T Cell Receptors ◽  
Extreme Value ◽  
Thymic Selection ◽  
Cell Receptors ◽  
Selection Of

scholarly journals Selection of T-cell receptors with a recurrent CDR3β peptide-contact motif within the repertoire of alloreactive CD8+ T cells

2011 ◽  
Vol 41 (8) ◽  
pp. 2414-2423 ◽  
Author(s):  
Caroline Scifo ◽  
Laura Mekaelian ◽  
Elisaphane Munyazesa ◽  
Anne-Marie Schmitt-Verhulst ◽  
Annick Guimezanes
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd8 T Cells ◽  
T Cell Receptors ◽  
Cell Receptors ◽  
Selection Of
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