Effects of food deprivation on neuropeptide Y (NPY) gene expression and GH secretion in goldfish (Carassius auratus)

ABSTRACT The genotypes of three color mutants in goldfish: a depigmentation character of larval melanophores, albinism and a recessive-transparent character, were analyzed by crossing experiments. The depigmentation character in the common goldfish is controlled by two dominant multiple genes, Dp 1 and Dp2, and only fish with double recessive alleles dp1dp1 dp2dp2 can retain larval melanophores throughout life. Albinism is also controlled by double autosomal genes, p and c. The genotype of an albino fish is represented by pp cc; the non-albino fish is PP CC. Fish with either a pp CC or pp Cc genotype are albino when scored at the time of melanosome differentiation in the pigment retina, but after the time of skin melanophore differentiation, they change to the nonalbino type under the control of the C gene. The recessive-transparent character is controlled by a single autosomal gene, g. The mechanisms of gene expression of these characters were proposed as a result of observation and/or experimental data on the differentiation processes of their phenotypes, and the genotypes of these color mutant goldfish were considered in relation to the "gene duplication hypothesis in the Cyprinidae."

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Role of hypothalamic neuropeptide Y gene expression in body weight regulation

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.1994.266.5.r1687 ◽

1994 ◽

Vol 266 (5) ◽

pp. R1687-R1691 ◽

Cited By ~ 4

Author(s):

L. Davies ◽

J. L. Marks

Keyword(s):

Gene Expression ◽

Body Weight ◽

Neuropeptide Y ◽

Food Deprivation ◽

Serum Insulin ◽

Serum Glucose ◽

Weight Regulation ◽

Body Weight Regulation ◽

Insulin Levels ◽

Male Wistar Rats

Hypothalamic neuropeptide Y (NPY) may be involved in the hyperphagia that follows food deprivation associated with significant weight loss. However, it is unclear whether NPY is involved in body weight regulation under more physiological circumstances. Consequently, we measured body weight, food intake, arcuate nucleus (ARC) NPY mRNA, serum glucose, and insulin in male Wistar rats after 48 h of food deprivation and various refeeding protocols. Food deprivation produced a twofold increase in NPY mRNA, whereas 3 days of ad libitum refeeding returned body weight and NPY mRNA to control. If hyperphagia was prevented for 5 days during refeeding, then neither body weight nor NPY mRNA normalized. There were strong negative correlations between ARC NPY mRNA and both loss of body weight and serum insulin levels. These data suggest that hypothalamic NPY gene expression plays a role in control of body weight under physiological conditions. The data further suggest that NPY mRNA may be decreased by peripheral insulin levels.

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Macrophage colony-stimulating factor (CSF-1) induces pro-inflammatory gene expression and enhances antimicrobial responses of goldfish (Carassius auratus L.) macrophages

Fish & Shellfish Immunology ◽

10.1016/j.fsi.2008.12.001 ◽

2009 ◽

Vol 26 (3) ◽

pp. 406-413 ◽

Cited By ~ 34

Author(s):

Leon Grayfer ◽

Patrick C. Hanington ◽

Miodrag Belosevic

Keyword(s):

Gene Expression ◽

Carassius Auratus ◽

Colony Stimulating Factor ◽

Inflammatory Gene Expression ◽

Inflammatory Gene ◽

Goldfish Carassius Auratus ◽

Macrophage Colony Stimulating Factor ◽

Macrophage Colony ◽

Stimulating Factor

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Neuropeptide Y gene expression in the jerboa arcuate nucleus: modulation by food deprivation and relationship with hibernation

Neuroscience Letters ◽

10.1016/s0304-3940(01)01825-0 ◽

2001 ◽

Vol 305 (2) ◽

pp. 127-130 ◽

Cited By ~ 6

Author(s):

Seloua El Ouezzani ◽

Pierrette Lafon ◽

Gérard Tramu ◽

Rabia Magoul

Keyword(s):

Gene Expression ◽

Neuropeptide Y ◽

Food Deprivation ◽

Arcuate Nucleus

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Effect of vitamin D3 (cholecalciferol) on plasma calcium and intestinal 45calcium absorption in goldfish, Carassius auratus L.

Canadian Journal of Zoology ◽

10.1139/z84-007 ◽

1984 ◽

Vol 62 (1) ◽

pp. 34-36 ◽

Cited By ~ 14

Author(s):

James C. Fenwick

Keyword(s):

Vitamin D ◽

Food Deprivation ◽

Vitamin D3 ◽

Carassius Auratus ◽

Calcium Absorption ◽

Plasma Calcium ◽

Intestinal Calcium Absorption ◽

Total Calcium ◽

Goldfish Carassius Auratus

Goldfish that were fed as well as not fed for 2 weeks had similar plasma total calcium levels, and vitamin D3 injections during the last 6 days had no significant effect on this parameter. When fish were fed for 1 day after 13 days of food deprivation, plasma calcium increased significantly and this increase was augmented by vitamin D3 injections. This latter group also showed a chlorpromazine-sensitive increase in 45calcium absorption from perfused everted gut sacs when compared with the controls. It was concluded that vitamin D3 stimulates intestinal calcium absorption in the goldfish.

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