OL-063 Antibiotic susceptibility of Serratia spp. isolated from hospitalised patients in a general hospital

Hospital-acquired venous thromboembolism (VTE) accounts for an estimated 25 000 preventable deaths per annum in the UK and is associated with significant healthcare costs. The National Institute for Health and Care Excellence guidelines on the prevention of VTE in hospitalised patients highlight the clinical and cost-effectiveness of VTE prevention strategies. A multidisciplinary quality improvement team (MD QIT) based in a district general hospital sought to improve compliance with VTE prophylaxis prescription to greater than 85% of patients within a 3-month time frame. Quality improvement methodology was adopted over three cycles of the project. Interventions included the introduction of a ‘VTE sticker’ to prompt risk assessment; educational material for medical staff and allied healthcare professionals; and patient information raising the awareness of the importance of VTE prophylaxis. Implementation of these measures resulted in significant and sustained improvements in rates of risk assessment within 24 hours of admission to hospital from 51% compliance to 94% compliance after cycle 2 of the project. Improvements were also observed in medication dose adjustment for the patient weight from 69% to 100% compliance. Dose adjustments for renal function showed similar trends with compliance with guidelines improving from 80% to 100%. These results were then replicated in a different clinical environment. In conclusion, this project exemplifies the benefits of MD QITs in terms of producing sustainable and replicable improvements in clinical practice and in relation to meeting approved standards of care for VTE risk assessment and prescription. It has been demonstrated that the use of educational material in combination with a standardised risk assessment tool, the ‘VTE sticker’, significantly improved clinical practice in the context of a general medical environment.

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Characteristics of nocardiosis patients with different immune status from a Chinese tertiary general hospital during 8-year period

10.21203/rs.2.16153/v1 ◽

2019 ◽

Author(s):

Lei Huang ◽

Liying Sun ◽

Yan Yan

Keyword(s):

Soft Tissue ◽

General Hospital ◽

Species Identification ◽

Clinical Data ◽

Antibiotic Susceptibility ◽

Clinical Characteristics ◽

Kidney Diseases ◽

Test Method ◽

Chronic Kidney Diseases ◽

Nocardia Species

Abstract Background: Nocardia is an opportunistic pathogen from environment, which is generally thought to infect immunosuppressed patients (ISPs), but recent studies showed it could also cause infections in immunocompetent patients (ICPs). Objective: To compare the clinical characteristics, patients’ outcome, Nocardia species identification and antibiotic susceptibility profiles of nocardiosis between ICPs and ISPs. Methods: The detailed clinical data were collected from all the non-repetitive nocardiosis patients during 2011 and 2018, from a tertiary general hospital in Beijing, China. Then each Nocardia isolate was identified to species level by DNA sequencing. The antibiotic susceptibility testing was performed by E-test method, and interpreted following CLSI M24 document. The clinical and microbiological characteristics between ICPs and ISPs were compared statistically. Results: A total of 23 non-repetitive nocardiosis patients with detailed clinical data were enrolled in this study. Among them, 9 were ICPs and 14 were ISPs. All the skin and soft tissue infections occurred in ICPs (33.3% versus 0%, P<0.05). Bronchiectasis occurred more frequently in ICPs (44.4% versus 21.4%), while chronic kidney diseases and co-infection with aspergillosis occurred more frequently in ISPs (35.7% versus 0%, 35.7% versus 0%, respectively), although they did not reach the statistical significance. There were no significant difference in other clinical characteristics, Nocardia species identification, and antibiotic susceptibility between ISPs and ICPs (P>0.05). Conclusion: Nocardiosis could occur in both ISPs and ICPs. Skin and soft tissue infection and bronchiectasis occurred more frequently in ICPs. Chronic kidney diseases and co-infection with aspergillosis occurred more frequently in ISPs. These characteristics should be noticed by physicians in diagnosis of nocardiosis.

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Bacterial Pattern and Antibiotic Susceptibility in the Perinatology Unit of Haji Adam Malik General Hospital Medan, Indonesia

Proceedings of the 2nd International Conference on Tropical Medicine and Infectious Disease ◽

10.5220/0009861601150118 ◽

2019 ◽

Author(s):

Nisa Nurjannah ◽

Beby Syofiani Hasibuan

Keyword(s):

General Hospital ◽

Antibiotic Susceptibility

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BACTERIAL ETIOLOGY AND ANTIBIOTIC SUSCEPTIBILITY PATTERN IN VENTILATOR‐ASSOCIATED PNEUMONIA AT INTENSIVE CARE UNIT, CA MAU GENERAL HOSPITAL.

Respirology ◽

10.1111/resp.13700_113 ◽

2019 ◽

Vol 24 (S2) ◽

pp. 132-132

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

General Hospital ◽

Antibiotic Susceptibility ◽

Ventilator Associated Pneumonia ◽

Susceptibility Pattern ◽

Antibiotic Susceptibility Pattern

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Antibiotic susceptibility patterns of some clinical isolates from al-rass general hospital

International Journal of Biosciences (IJB) ◽

10.12692/ijb/6.9.47-54 ◽

2015 ◽

Vol 6 (9) ◽

pp. 47-54 ◽

Cited By ~ 1

Keyword(s):

General Hospital ◽

Antibiotic Susceptibility ◽

Clinical Isolates ◽

Antibiotic Susceptibility Patterns ◽

Susceptibility Patterns

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Prevalence of extended-spectrum beta-lactamase producing gram negative isolates in Enterobacteriaceae group of bacteria in clinical samples from a tertiary care hospital

10.17727/jmsr.2021/9-23 ◽

2021 ◽

Vol 9 (3) ◽

pp. 162-168

Author(s):

Parmar M ◽

Halpati A ◽

Desai K

Keyword(s):

General Hospital ◽

Antibiotic Susceptibility ◽

Tertiary Care ◽

Diffusion Method ◽

Clinical Samples ◽

Care Hospital ◽

Microbiology Laboratory ◽

Gram Negative ◽

Extended Spectrum ◽

Antibiotic Susceptibility Test

Introduction: Extended spectrum β-lactamases (ESBLs) are enzymes that intervene resistance to extended-spectrum (third generation) cephalosporins (e.g., ceftazidime, cefotaxime, and ceftriaxone) and but do not affect carbapenems (e.g., meropenem or imipenem). Though the number of ESBLs producing organism has been increasing day by day, the detection methods and treatment option for them are extremely limited. Objective: Objective of the study was to investigate the rate of ESBLs production and their antibiotic susceptibility pattern. Materials and method: A total 200 Gram negative isolates from various clinical samples received in microbiology laboratory, Sir Takhtsinhji General Hospital, Bhavnagar were studied and Antibiotic susceptibility test was done for commonly used antibiotics. A hospital-based study was conducted in microbiology laboratory, Sir Takhtsinhji General Hospital, Bhavnagar from February 2012 to August 2012. A total of 200 Gram negative isolates from various clinical samples were collected and identified using the conventional biochemical tests following the Clinical and Laboratory Standard Institute (CLSI) guidelines. Antimicrobial susceptibility testing (AST) was performed using the standardized Kirby-Bauer disk diffusion method. Results: Among the total isolates 89(44.5%) were ESBLs producer, and the rate of ESBLs positivity was 39.8% for E. coli (33 out of 83), 10% for Proteus mirabilis (1 out of 10), 51.4% for Klebsiella spp (55 out of 107). ESBLs producing organisms were resistant to most of the antibiotics but 100% were sensitive to imipenem, meropenem, and cefoperazone + sulbactam. Conclusion: Screening for ESBLs production requires to be carried out regularly in all clinical diagnostic laboratories to direct clinicians in appropriate selection of antibiotics.

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