Development of Retinal Ganglion Cell Structure and Function

2001 ◽  
Vol 20 (2) ◽  
pp. 139-174 ◽  
Author(s):  
Evelyne Sernagor ◽  
Stephen J Eglen ◽  
Rachel O.L Wong
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Structure ◽  
Structure And Function ◽  
Retinal Ganglion ◽  
And Function

XIAP gene therapy effects on retinal ganglion cell structure and function in a mouse model of glaucoma

Gene Therapy ◽  
2021 ◽  
Author(s):  
Shagana Visuvanathan ◽  
Adam N. Baker ◽  
Pamela S. Lagali ◽  
Stuart G. Coupland ◽  
Garfield Miller ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Mouse Model ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Structure ◽  
Structure And Function ◽  
Retinal Ganglion ◽  
And Function

scholarly journals Acetylation Preserves Retinal Ganglion Cell Structure and Function in a Chronic Model of Ocular Hypertension

2014 ◽  
Vol 55 (11) ◽  
pp. 7486 ◽  
Author(s):  
Oday Alsarraf ◽  
Jie Fan ◽  
Mohammad Dahrouj ◽  
C. James Chou ◽  
Phillip W. Yates ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Ocular Hypertension ◽  
Retinal Ganglion Cell ◽  
Cell Structure ◽  
Structure And Function ◽  
Retinal Ganglion ◽  
Chronic Model ◽  
And Function

scholarly journals Independent modes of ganglion cell translocation ensure correct lamination of the zebrafish retina

2016 ◽  
Vol 215 (2) ◽  
pp. 259-275 ◽  
Author(s):  
Jaroslav Icha ◽  
Christiane Kunath ◽  
Mauricio Rocha-Martins ◽  
Caren Norden
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Light Sheet ◽  
Retinal Layer ◽  
Retinal Ganglion ◽  
Layer Formation ◽  
Neuronal Connectivity ◽  
Light Sheet Microscopy ◽  
And Function

The arrangement of neurons into distinct layers is critical for neuronal connectivity and function. During development, most neurons move from their birthplace to the appropriate layer, where they polarize. However, kinetics and modes of many neuronal translocation events still await exploration. In this study, we investigate retinal ganglion cell (RGC) translocation across the embryonic zebrafish retina. After completing their translocation, RGCs establish the most basal retinal layer where they form the optic nerve. Using in toto light sheet microscopy, we show that somal translocation of RGCs is a fast and directed event. It depends on basal process attachment and stabilized microtubules. Interestingly, interference with somal translocation induces a switch to multipolar migration. This multipolar mode is less efficient but still leads to successful RGC layer formation. When both modes are inhibited though, RGCs fail to translocate and induce lamination defects. This indicates that correct RGC translocation is crucial for subsequent retinal lamination.

scholarly journals Form and Function of the M4 Cell, an Intrinsically Photosensitive Retinal Ganglion Cell Type Contributing to Geniculocortical Vision

2012 ◽  
Vol 32 (39) ◽  
pp. 13608-13620 ◽  
Author(s):  
M. E. Estevez ◽  
P. M. Fogerson ◽  
M. C. Ilardi ◽  
B. G. Borghuis ◽  
E. Chan ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Retinal Ganglion ◽  
Cell Type ◽  
Form And Function ◽  
And Function

scholarly journals Retinal Ganglion Cell Axon Guidance in the Mouse Optic Chiasm: Expression and Function of Robos and Slits

2000 ◽  
Vol 20 (13) ◽  
pp. 4975-4982 ◽  
Author(s):  
Lynda Erskine ◽  
Scott E. Williams ◽  
Katja Brose ◽  
Thomas Kidd ◽  
Rivka A. Rachel ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Axon Guidance ◽  
Retinal Ganglion Cell ◽  
Optic Chiasm ◽  
Retinal Ganglion ◽  
Retinal Ganglion Cell Axon ◽  
Cell Axon ◽  
And Function ◽  
Ganglion Cell Axon
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