O-44 Evaluation of estrogen and progesterone receptor, Her-2 and Topo IIα in primary breast cancer and metastatic axillary lymph nodes

2007 ◽  
Vol 5 (3) ◽  
pp. 14
Author(s):  
B. Ataseven ◽  
D. Michler ◽  
B. Hoegel ◽  
M. Beer ◽  
W. Eiermann
Keyword(s):  
Breast Cancer ◽  
Progesterone Receptor ◽  
Lymph Nodes ◽  
Primary Breast Cancer ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Her 2 ◽  
Estrogen And Progesterone Receptor

Preoperative Staging of Large Primary Breast Cancer With [18F]Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Compared With Conventional Imaging Procedures

2008 ◽  
Vol 26 (29) ◽  
pp. 4746-4751 ◽  
Author(s):  
David Fuster ◽  
Joan Duch ◽  
Pilar Paredes ◽  
Martín Velasco ◽  
Montserrat Muñoz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Sensitivity And Specificity ◽  
Primary Breast Cancer ◽  
Distant Metastases ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Pet Ct ◽  
Large Primary

Purpose To evaluate the utility of positron emission tomography (PET) and [18F]fluorodeoxyglucose in the initial staging of large primary breast tumors. Patients and Methods This prospective study was approved by the ethics committee, and all patients gave their informed consent before enrollment. Sixty consecutive patients with large (> 3 cm) primary breast cancer diagnosed by clinical examination and breast magnetic resonance imaging (MRI) were entered onto the study. The mean age was 57 ± 13 years. Chest computed tomography (CT), liver ultrasonography, bone scan, and PET/CT were performed in all patients. All findings were histologically confirmed, and/or at least 1 year of follow-up was required. Correlation between parameters was calculated using Pearson's correlation coefficient. P < .05 was considered statistically significant. Results Primary tumor was identified by both PET/CT and MRI in all patients. Multifocal and/or multicentric tumors were found in 19 patients by MRI. Axillary lymph node metastases were found in 20 of 52 patients. Extra-axillary metastatic lymph nodes were also found in three patients. One patient showed an infiltrated lymph node in the contralateral axilla. The sensitivity and specificity for PET/CT to detect axillary lymph nodes metastases were 70% and 100%, respectively. PET/CT diagnosed all extra-axillary lymph nodes. The overall sensitivity and specificity of PET/CT in detecting distant metastases were 100% and 98%, respectively; whereas the sensitivity and specificity of conventional imaging were 60% and 83%, respectively. PET led to a change in the initial staging in 42% of patients. Conclusion PET/CT underestimates locoregional lymph node staging in large primary breast cancer patients. PET/CT is a valuable tool to discard unsuspected extra-axillary lymph nodes and distant metastases.

Evaluation of the expression levels of nm23-h1 mRNA in primary breast cancer, benign breast disease, axillary lymph nodes and normal breast tissue

Pathology ◽  
1994 ◽  
Vol 26 (4) ◽  
pp. 423-428 ◽  
Author(s):  
Rebecca J. Goodall ◽  
Hugh J.S. Dawkins ◽  
Peter D. Robbins ◽  
Erika Hähnel ◽  
Mohinder Sarna ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Primary Breast Cancer ◽  
Breast Tissue ◽  
Benign Breast Disease ◽  
Normal Breast Tissue ◽  
Breast Disease ◽  
Normal Breast ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph

scholarly journals Correlation of the HER-2 protein expression and other clinicopathological features of ductal infiltrative breast cancer

2005 ◽  
Vol 5 (1) ◽  
pp. 3-7 ◽  
Author(s):  
Svjetlana Radović ◽  
Mirsad Babić ◽  
Mirsad Dorić ◽  
Edina Balta ◽  
Erol Kapetanović ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Vascular Invasion ◽  
Protein A ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Regional Lymph Nodes ◽  
Tissue Samples ◽  
Poor Grade ◽  
Her 2

The aim of the study was to investigate the relationship between the expression of the HER-2 membrane protein and other clinical-pathological parameters such as: histological size of the tumor, degree of the tumor's differentiation, presence of vascular invasion and presence of metastases in regional lymph nodes, in cases of ductal infiltrative breast cancer. We have investigated 56 cases of ductalinfiltrative breast cancer. In all patients a mastectomy with a dissection of axillary lymph nodes has been performed. All tissue samples, taken by biopsy, were embedded in the paraffin, stained by hematoxylin-eosin technique and screened, and evaluation was performed by using a semiquantitative method of the immunohistochemical expression of the HER-2 protein. A decrease of the protein HER-2 expression was noticed in cases of an increase of the tumor's diameter above 50 mm. Increased expression of the HER-2 protein was noticed in cases of moderate (grade II) and poor (grade III) differentiation of carcinoma, as well as in cases where there was no metastases in the regional lymph nodes. No relationship has been observed between the expression of HER-2 and occurrence of vascular invasion. In cases of ductalinfiltrative breast cancer the expression of HER-2 protein is in correlation with the size and degree of tumor's differentiation, as well as with the presence of metastases in regional lymph nodes.

Discordence of HER-2/neu overexpression and estrogen receptor between the primary breast cancer and axillary lymph node with metastasis

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 20106-20106
Author(s):  
R. K. Shahid ◽  
I. Ahmad ◽  
S. Yadav ◽  
A. Sami ◽  
K. Haider ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Primary Tumor ◽  
Axillary Lymph Node ◽  
Primary Breast Cancer ◽  
Fish Analysis ◽  
Axillary Lymph ◽  
Her 2

20106 Background: Adjuvant hormonal therapy and trastuzumab are known to be associated with a significant reduction in cancer-related mortality in a subset of women with breast cancer. The treatment decision is usually based on immunohistochemistry (IHC) staining of the primary tumor. We reported here a case of discordance of HER-2/neu overexpression and estrogen receptor status between the primary breast cancer and axillary lymph node with metastasis. Methods: IHC and fluorescence in situ hybridization (FISH) analysis was perfromed for the assessment of HER-2/neu. E-cadherin staining was done on the primary tumor and lymph node with metastasis. Results: A 52 year old woman presented with right breast lump. The imaging studies showed a 5 × 5 cm speculated mass. No other abnormalities were noted. An excision biopsy revealed 3 cm moderately differentiated invasive lobular carcinoma. Subsequently a wider excision and axillary lymph node dissection was done. 2/20 lymph nodes were involved by the cancer. IHC was done in the primary tumor and the lymph node with metastasis. IHC of the primary tumor revealed less than 1% nuclei positive for estrogen receptor (ER), 0% nuclei positive for progesterone receptor (PR), and no HER-2/neu overexpression. IHC of the lymph nodes with metastasis revealed 80% nuclei positive for ER, less than 1% nuclei positive for PR, and equivocal HER-2/neu overexpression. FISH analysis for HER-2/neu gene was done on the primary tumor which revealed no amplification in the tumor nuclei (Her2/CEP17 ratio was 3.6/2.7 = 1.3) whereas FISH analysis on the lymph node section revealed amplification in tumor nuclei (Her2/CEP 17 ratio of 7.3/1.9 = 3.9). E-cadherin staining of the primary breast tumor as well as the lymph node with metastasis revealed no membrane staining of the malignant cells in either section. Conclusions: The unusual occurrence of a divergent IHC profile and FISH analysis results between the primary carcinoma and metastatic carcinoma may be due to a subselection of a malignant clone which were not represented in the section of primary tumor chosen for IHC. Future studies are required to determine the utility of IHC staining of metastatic cells involving the lymph nodes if primary tumor is negative for HER-2/neu & ER. No significant financial relationships to disclose.

Tuberculosis of axillary lymph nodes with primary breast cancer

Breast Cancer ◽  
2003 ◽  
Vol 10 (2) ◽  
pp. 175-178 ◽  
Author(s):  
Takaaki Fujii ◽  
Morihiko Kimura ◽  
Yasuhiro Yanagita ◽  
Tokihiro Koida ◽  
Hiroyuki Kuwano
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Primary Breast Cancer ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph

scholarly journals Prognostic Factors on the Positivity for Metastases of the Axillary Lymph Nodes from Primary Breast Cancer

PRILOZI ◽  
2017 ◽  
Vol 38 (1) ◽  
pp. 81-90
Author(s):  
Borislav Kondov ◽  
Goran Kondov ◽  
Zoran Spirovski ◽  
Zvonko Milenkovikj ◽  
Risto Colanceski ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Regression Analysis ◽  
Lymph Nodes ◽  
Primary Breast Cancer ◽  
Lymphovascular Invasion ◽  
Treated Patient ◽  
Univariate Analysis ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
The Impact

Abstract Aim: The aim of the study was to identify the impact of T stage, the presence of estrogen, progesterone, HER2neu receptors and the values of the Ki67 on the positivity for metastases of the axillary lymph nodes, from primary breast cancer. Material and methods: 290 surgically treated patients for breast cancer were included in the study. All cases have been analyzed by standard histological analysis including microscopic analysis on standard H&E staining. For determining the molecular receptors - HER2neu, ER, PR, p53 and Ki67, immunostaining by PT LINK immunoperoxidase has been done. Results: Patients age was ranged between 18-90 years, average of 57.6+11.9. The mean size of the primary tumor in the surgically treated patient was 30.27 + 18.3 mm. On dissection from the axillary pits 8 to 39 lymph nodes were taken out, an average of 13.81+5.56. Metastases have been found in 1 to 23 lymph nodes, an average 3.14+4.71. In 59% of the patients there have been found metastases in the axillary lymph nodes. The univariate regression analysis showed that the location, size of tumor, differentiation of the tumor, stage, the value of the Ki67 and presence of lymphovascular invasion influence on the positivity of the axillary lymph nodes. The presence of the estrogen receptors, progesterone receptors and HER2neu receptors showed that they do not have influence on the positivity for metastatic deposits in axillary lymph nodes. The multivariate model and the logistic regression analysis as independent significant factors or predictors of positivity of the axillary lymph nodes are influenced by the tumor size and the positive lymphovascular invasion. Conclusion: Our study showed that the involving of the axillary lymph nodes is mainly influenced by the size of the tumor and the presence of lymphovascular invasion in the tumor. Ki67 determined proliferative index in the univariate analysis points the important influence of positivity in the axillary lymph nodes, but not in the multivariate regressive analysis.

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