Erucylphosphohomocholine-induced apoptosis in human glioma cells: role of the oligomycin-sensitive F0 part of mitochondrial H+-ATP-synthase

2008 ◽  
Vol 6 (9) ◽  
pp. 81
Author(s):  
W. Kugler ◽  
P. Hülper ◽  
M. Lakomek ◽  
M. Gavish ◽  
L. Veenman
2004 ◽  
Vol 25 (6) ◽  
pp. 915-924 ◽  
Author(s):  
Byung Kwan Choi ◽  
Chang Hwa Choi ◽  
Hyun Lim Oh ◽  
Yong Keun Kim

2007 ◽  
Vol 6 (1) ◽  
pp. 42 ◽  
Author(s):  
Pabbisetty Kumar ◽  
Anjali Shiras ◽  
Gowry Das ◽  
Jayashree C Jagtap ◽  
Vandna Prasad ◽  
...  

2015 ◽  
Vol 10 (4) ◽  
pp. 966
Author(s):  
Ji-Heng Hao ◽  
Dian-Feng Hu ◽  
Li-Mei Mao ◽  
Shi-Gang Zhang ◽  
Ji-Yue Wang ◽  
...  

<p class="Abstract">The present study was performed to investigate the effect of 2-fluorobenzaldehyde retinoic acid conjugate on activation of STAT3 pathway in human glioma cells. The results revealed that the compound exhibited inhibitory effect on the activation of STAT3 induced constitutively and by interleukin-6. The inhibitory effect on STAT3 activation was found to be concentration- and time-dependent. In U373 glioma cells, 2-fluorobenzaldehyde retinoic acid conjugate treatment caused a significant enhancement in the expression of proapoptotic proteins like Bax and Bak. Its treatment inhibited the expression of genes including, cyclin D1, Bcl-2, Bcl-xL, survivin, Mcl-1, and vascular endothelial growth factor (VEGF) in U373 glioma cells. Furthermore, the conjugate inhibited proliferation, induced apoptosis and caused accumulation of cells in G1-G0 phase of cell cycle. Thus, 2-fluorobenzaldehyde retinoic acid conjugate acts as a potent inhibitor of STAT3 activation that can be promising importance for the prevention and treatment of gliomas.</p><p> </p>


2014 ◽  
Vol 35 (9) ◽  
pp. 1199-1206 ◽  
Author(s):  
Yun-wei Ou ◽  
Zi-tong Zhao ◽  
Chuan-yue Wu ◽  
Bai-nan Xu ◽  
Yong-mei Song ◽  
...  

Oncogene ◽  
2000 ◽  
Vol 19 (19) ◽  
pp. 2338-2345 ◽  
Author(s):  
Mirjam Hermisson ◽  
Bettina Wagenknecht ◽  
Hartwig Wolburg ◽  
Tamara Glaser ◽  
Johannes Dichgans ◽  
...  

FEBS Letters ◽  
2010 ◽  
Vol 584 (16) ◽  
pp. 3519-3524 ◽  
Author(s):  
Ting-Kuang Niu ◽  
Yan Cheng ◽  
Xingcong Ren ◽  
Jin-Ming Yang

2005 ◽  
Vol 30 (2) ◽  
pp. 263-270 ◽  
Author(s):  
Won Chang Lee ◽  
Chang Hwa Choi ◽  
Seung Heon Cha ◽  
Hyun Lim Oh ◽  
Yong Keun Kim

2004 ◽  
Vol 67 (3) ◽  
pp. 273-280 ◽  
Author(s):  
Ryuta Saito ◽  
Masaaki Mizuno ◽  
Manabu Hatano ◽  
Toshihiro Kumabe ◽  
Takashi Yoshimoto ◽  
...  

BMC Neurology ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Bing Zhao ◽  
Hongliang Wang ◽  
Gang Zong ◽  
Ping Li

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